PURPOSE: Nocturnal enuresis is one of the most common disorders of childhood, occurring in 15% of 5 year-old children. Although usually self-limiting, justification for early treatment has been founded in psyc hological impact on the child. Many investigators have reported upon the effectiveness of prospectively studied to compare the therapeutic effect between imipramine (Tofranil) and desmopressin (Minirin/1-Desamino-8-D-Arginine Vasopressin: DDAVP) on the monosymptomatic enuretic patients. MATERIALS AND METHODS: 83 enuretic patients (primary enuresis 64 cases, secondary enuresis 19 cases) were randomized th one of two groups: imipramine group(44 cases) or desmopressin group (39 cases). They were free of other abnormalities in the screening tests. In addition to drug therapy, all of cases were performed motivational counselling, reduction of fluid in take prior to bedtime and voiding diary. The efficacy of drug was measured in reduction of the number of wet nights per week. During the treatment period, 83 cases were classified as excellent (0 to 1 wet night per week), good (over 59% reduction of wet night)and failed responder(less than 50% reduction of wet night). RESULTS: Average age of imipramine group and desmopressin group was 9.3 years (range 5-17) and 9.6 years (range 5-17), respectively. The number of wet nights per week decreased respectively from a mean of 6.1 to 3.4 in imipramine group are from a mean of 6.4 to 2.3 in desmopressin group. Average therapeutic duration and overall response rate in the imipeamine group and desmopressin group was 9.1 weeks, 6.7 weeks (p<0.05) and 90.9%, 95.9%, respectively (p<0.05). The overall relapse rate of imipramine group and desmopressin group was 40.0% and 40.8% during the follow-up period of 3 months after cessation of medication in excellent responders. There was no difference in the therapeutic effects between primary and secondary enuresis on each drug therapy. There was also on no difference in the therapeutic response according to constipation. No serious side effects were observed in both groups. CONCLUSIONS: These data suggest that the overall effects of imipramine and desmopressin are excellent. But desmopressin has more effective therapeutic response and more shorter therapeutic duration as compared with imipramine.
Child ; Child, Preschool ; Constipation ; Deamino Arginine Vasopressin* ; Drug Therapy ; Enuresis ; Follow-Up Studies ; Humans ; Imipramine* ; Mass Screening ; Nocturnal Enuresis ; Prospective Studies ; Recurrence ; Research Personnel ; Vasopressins

A case study of a 76-year-old man with end-stage chronic obstructive pulmonary disease (COPD) with refractory breathlessness and the challenges in managing the dyspnoea he had been experiencing are described. A multi-modal approach is the mainstay of management, encompassing pharmacological agents, home oxygen therapy, and non-pharmacological approaches, namely, breathing techniques and smoking cessation. As this patient was at an advanced stage of disease, integration of palliative care with disease care was needed. Administering oxygen therapy for a patient who is still smoking and has household members who are current smokers need firm adherence to rules. The AIC HOME Programme is also briefly described.

No abstract available.
Humans ; Indomethacin* ; Infant, Newborn*

No abstract available.

Morphologically, kyphosis is devided into two groups, pure kyphosis and kyphoscoliosis, according to whether or not scoiiosis is combined. Or kyphosis can be devided into round kyphosis or angular kyphosis. The examples of round kyphosis are Scheuermanns kyphosis or ankylosing spondylitis. Acute angular kyphosis are of congenital kyphosis or old healed tuberculosis. The purpose of surgical correction of fixed kyphosis is to correct deformity as well as to prevent or to recover from paraplegia. The operation also improve respiratory and digestive function by diminishing compression of abdomen. However, the correction of this deformity is more dangerous in eliciting paraplegia than any other spinal deformity. In considering surgical correction of kyphosis we have to decide which approach is the best for that particular patient at that particular time. Usually majority of patient need combined anterior and posterior approach. The extent of fusion depends upon the flexibility of the kyphosis. Anterior fusion should encompass at least the rigid and inflexible portion of the kyphosis as determined by the hyperextension x-ray of the spine. Posterior fusion should encompass the full extent of the kyphosis. The purpose of this study is to report our results for surgical correction and to find the operative procedure which shows the best result. We hereby report surgically corrected 14 cases of fixed kyphosis who were hospitalized here from April 1988 to February 1995.
Abdomen ; Congenital Abnormalities ; Humans ; Kyphosis* ; Paraplegia ; Pliability ; Scheuermann Disease ; Spine ; Spondylitis, Ankylosing ; Surgical Procedures, Operative ; Tuberculosis

Diabetic foot ulcers are among the most severe complications in diabetes patients, often leading to life-threatening consequences if not treated appropriately. This study reviews the key treatment approaches outlined in the 2023 International Working Group on the Diabetic Foot (IWGDF) guidelines, focusing on wound debridement, dressing selection, and adjunctive therapies such as negative pressure wound therapy, leucocyte/platelet/fibrin patch, and hyperbaric oxygen therapy. The guidelines emphasize a multidisciplinary approach to accelerate wound healing and reduce recurrence and amputation rates. The findings suggest that integrating these advanced techniques with consistent patient monitoring and self-care education can improve clinical outcomes and prevent ulcer recurrence. This study concludes that further advancements in treatment and monitoring strategies will continue to enhance diabetic foot care, benefitting patient quality of life.

Diabetic foot ulcers are among the most severe complications in diabetes patients, often leading to life-threatening consequences if not treated appropriately. This study reviews the key treatment approaches outlined in the 2023 International Working Group on the Diabetic Foot (IWGDF) guidelines, focusing on wound debridement, dressing selection, and adjunctive therapies such as negative pressure wound therapy, leucocyte/platelet/fibrin patch, and hyperbaric oxygen therapy. The guidelines emphasize a multidisciplinary approach to accelerate wound healing and reduce recurrence and amputation rates. The findings suggest that integrating these advanced techniques with consistent patient monitoring and self-care education can improve clinical outcomes and prevent ulcer recurrence. This study concludes that further advancements in treatment and monitoring strategies will continue to enhance diabetic foot care, benefitting patient quality of life.

Diabetic foot ulcers are among the most severe complications in diabetes patients, often leading to life-threatening consequences if not treated appropriately. This study reviews the key treatment approaches outlined in the 2023 International Working Group on the Diabetic Foot (IWGDF) guidelines, focusing on wound debridement, dressing selection, and adjunctive therapies such as negative pressure wound therapy, leucocyte/platelet/fibrin patch, and hyperbaric oxygen therapy. The guidelines emphasize a multidisciplinary approach to accelerate wound healing and reduce recurrence and amputation rates. The findings suggest that integrating these advanced techniques with consistent patient monitoring and self-care education can improve clinical outcomes and prevent ulcer recurrence. This study concludes that further advancements in treatment and monitoring strategies will continue to enhance diabetic foot care, benefitting patient quality of life.

Diabetic foot ulcers are among the most severe complications in diabetes patients, often leading to life-threatening consequences if not treated appropriately. This study reviews the key treatment approaches outlined in the 2023 International Working Group on the Diabetic Foot (IWGDF) guidelines, focusing on wound debridement, dressing selection, and adjunctive therapies such as negative pressure wound therapy, leucocyte/platelet/fibrin patch, and hyperbaric oxygen therapy. The guidelines emphasize a multidisciplinary approach to accelerate wound healing and reduce recurrence and amputation rates. The findings suggest that integrating these advanced techniques with consistent patient monitoring and self-care education can improve clinical outcomes and prevent ulcer recurrence. This study concludes that further advancements in treatment and monitoring strategies will continue to enhance diabetic foot care, benefitting patient quality of life.

Diabetic foot ulcers are among the most severe complications in diabetes patients, often leading to life-threatening consequences if not treated appropriately. This study reviews the key treatment approaches outlined in the 2023 International Working Group on the Diabetic Foot (IWGDF) guidelines, focusing on wound debridement, dressing selection, and adjunctive therapies such as negative pressure wound therapy, leucocyte/platelet/fibrin patch, and hyperbaric oxygen therapy. The guidelines emphasize a multidisciplinary approach to accelerate wound healing and reduce recurrence and amputation rates. The findings suggest that integrating these advanced techniques with consistent patient monitoring and self-care education can improve clinical outcomes and prevent ulcer recurrence. This study concludes that further advancements in treatment and monitoring strategies will continue to enhance diabetic foot care, benefitting patient quality of life.