Biomedical Research ; trends ; Humans ; Liver Neoplasms

Anti-Bacterial Agents ; pharmacology ; Child ; Dyspepsia ; drug therapy ; Erythromycin ; analogs & derivatives ; pharmacology ; therapeutic use ; Gastroesophageal Reflux ; drug therapy ; Gastrointestinal Motility ; drug effects ; Humans ; Motilin ; pharmacology ; Receptors, Gastrointestinal Hormone ; drug effects ; Receptors, Neuropeptide ; drug effects

In recent years, the study on the molecular mechanism of tumorigenesis and cancer cell signals promotes the application of cancer-targeted therapy, which aims at cell receptors, key genes, and regulatory molecules in cancer cells. However, the polymorphism of targeting genes/molecules determines the clinical efficiency of these therapies. The application of gene polymorphism diagnosis in cancer-targeted therapy was reviewed.

The current strategies of anti-cancer therapy are mainly based on the evidence-based medicine, which is much better than be based on the doctor's experience. But we still need to make attempts to find the right drugs and doses for each patient. The patients with the same disease may receive different response to the same treatment because of their inherited and somatic genetic variability. This results in greatly different therapeutic outcome. The determination of anti-cancer drugs and the doses based on the individual genotype will open up a new era of personalized therapy.

Objective To research the diagnosis value in color Doppler ultrasound on traumatic retinal detachment. Methods 30 cases(30 eyes)with traumatic retinal detachment were confirmed by B-mode ultrasonography and surgery. The characteristics and blood flow were observed by color Doppler ultrasound. Results 30 cases, among partial detachment in 18 cases, completely detachment in 9 cases, old detachment in 2 cases, and completed with detachment of choroids in 1 case;30 cases, greater than 0.1 in 7 eyes ( 23.3% ), 0. 01 ～0. 1 in 10 eyes (33.3%),counting fingers in 4 eyes( 13.3% ) ,manual in 5 eyes ( 16.6% ) ,no light perception in 4 eyes( 13.3% ); The visual acuity in patients after treatment had significantly increased compared with before treatment( χ2 =7. 394 ,P =0. 015 );The lower intraocular pressure of retinal hemorrhage, serous choroidaland hemorrhagic choroidal had no significant difference[4 eye(33. 3% ) ,4 eye(33. 3% ) ,4 eye(33.3% ) ,respectively] (χ2 =3. 004,P=0. 343). Conclusion The color doppler ultrasound diagnosis in traumatic retinal detachment, with its capacity of early finding and accurate and reliable, have significant meaning to clinical treatment and prognosis.

Orphan nuclear receptor steroidogenic factor 1 (SF-1) is a member of the nuclear receptor superfamily. It regulates the expression of multiple genes involved in adrenal and gonadal development,steroidogenesis,and reproductive function. Twenty five different mutations have been described and their clinical features are various. Detection of SF-1 gene may be contribute to the etiological diagnosis for 46, XY disorder of sex development patients.

Antiviral Agents ; therapeutic use ; Carcinoma, Hepatocellular ; drug therapy ; virology ; Hepacivirus ; Hepatitis B virus ; Humans ; Liver Neoplasms ; drug therapy ; virology

Antiviral Agents ; therapeutic use ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Hepatitis B, Chronic ; drug therapy ; Humans ; Interferon-alpha ; therapeutic use ; Lamivudine ; therapeutic use ; Phytotherapy

China ; Dental Implants ; Health Services Needs and Demand ; Humans ; Periodontics ; manpower

ObjectiveTo investigate the value of S100B protein in the evaluation of prognosis for patients with severe brain injury.MethodsThe serum S100B protein concentration was determined by enzyme-linked immunosorbent assay in 86 patients with severe brain injury(observation group) and 89 healthy individuals(control group) from February 2009 to March 2011.The clinical symptom and Glasgow outcome scale(GOS) score were measured.ResultsIn the 86 patients of observation group,33 patients were with good-recovery,25 patients were with moderate-deficit,14 patients were with severe-deficit,1 patient was detected of persistent vegetative status,and 13 patients died.The rate of excellent prognosis and worse prognosis were 67.4％ (58/86) and 32.6％ (28/86).The concentration of S100B protein was obviously higher in observation group [ ( 1.42 ± 0.42 ) μ g/L ] than that in control group [ (0.16 ± 0.05 ) μ g/L ] in 24 hours (P ＜ 0.01 ).The concentration of S100B protein in worse prognosis [ (2.15 ± 0.51 ) μ g/L] was obviously higher than that in excellent prognosis [ ( 0.92 ± 0.49) μ g/L ] ( P ＜ 0.05).ConclusionsS100B protein has high sensitivity and specificity to evaluate brain injury,and it is a reliable and valid biochemical marker of the brain damage.It has important clinical value in the evaluation of severity and prediction of prognosis for patients with severe brain injury.