Objective To explore the effects and clinical application value of early stage functional exercise rehabilitation in patients with breast cancer modified radical surgery.Methods 104 postoperative breast cancer patients was divided into the observation group and control group by the random number table method,the control group was given routine exercise,the observation group was given early stage postoperative function exercise,the effect of the two groups of clinical rehabilitation was recorded.Results The total effectiveness of the observation group was 94.23%,which of the control group was 75.00%,the difference between the two groups was statistical significance (χ2 =7.386,P <0.05).The indexes in the observation group after the intervention were time of maximum heart rate (4.67 ±1.21)min,distance (256.37 ±30.19)m,heart rate recovery time (6.83 ±1.43)min,subjective feeling hard score (10.33 ±1.68);The control group after the intervention time of maximum heart rate (3.21 ±0.68)min, distance (189.71 ±17.83)m,heart rate recovery time (10.38 ±2.57)min,subjective feeling hard score (7.75 ± 0.65)points,the difference between the two groups was statistical significance (t =7.585,13.709,8.704,13.709, P <0.05).The observation group had 3 cases of upper limb,2 cases of edema,subcutaneous effusion,2 cases of skin flap necrosis;The control group in upper extremity edema in 11 cases,9 cases of subcutaneous effusion,8 cases of skin flap necrosis,the difference between the two groups was statistical significance (χ2 =5.282,4.981,5.282,P <0.05).Conclusion Application of function exercise early stage in patients with breast cancer can modified radical shoulder joint activity,improve patient endurance,reduce the postoperative complications,which is worthy of populari-zation and clinical application.

Objective To explore the effect of azithromycin sequential therapy on inflammatory cytokines and humoral immune function in the treatment of children with mycoplasma pneumonia.Methods 342 children with mycoplasma pneumonia were divided into control group(168 cases)treated with erythromycin sequential therapy and observation group (174 cases)treated with azithromycin sequential therapy based on the random number table.The changes of inflammatory cytokines and humoral immune function were recorded and compared.Results The levels of interleukin 4(IL -4),interleukin 6(IL -6),C -reactive protein(CRP)and tumor necrosis factor -α(TNF -α) had no significant differences between the two groups before accepting different treatments (P >0.05).The decreased levels of IL -4,IL -6,CRP and TNF -αof the observation group after treatment were greater than the control group (t =10.913,11.047,9.919,53.207,all P <0.01).The levels of immunoglobulin M(IgM),immunoglobulin G(IgG) and immunoglobulin A(IgA)had no significant differences between the two groups before accepting different treat-ments (P >0.05).After treatment,the decrease of IgM and IgG between the two groups had significant differences (t =3.178,3.034,all P <0.01 ).Conclusion Azithromycin sequential therapy for the treatment of children with mycoplasma pneumonia has better clinical efficacy than erythromycin sequential therapy,which can improve inflamma-tory cytokines index and regulate humoral immune function.It has considerable value in the clinical application.

Homing and engraftment of transplanted hematopoietic stem cells (HSCs) can directly influence the effect of the transplantation.Exploration on its spatial distribution,location and interaction with the bone marrow (BM) microenvironment is great significance.Since the BM cavity is closed and surrounded by thick compact bone,it makes a colossal challenge to track the transplanted HSCs in vivo directly.Recently,researchers used different innovative methods to observe the spatial distribution and interaction with the BM microenvironment of the transplanted HSCs.The present review summarized the progress in the HSCs transplantation.

Objective To understand the health status of the staff at a vocational technology college and analysis the cause of health problems.Methods The data were analyzed and had been statistical processing according to the physical examination reports of a total of 707 Changzhou hygiene teaching staff from 2011 to 2013.Results The top ten diseases and total prevalence were as follows:Abnormal electrocardiogram 48.44％ (295/609),dyslipidemia 39.97％ (247/618),the male prostate hyperplasia 38.82％ (73/188),the female mammae lobule hyperplasia and breast lump 29.05％ (147/506),hypertension 27.44％ (152/554),the female uterine myoma 21.94％ (111/506),fatty liver 21.77％ (133/611),hepaticcysts 20.62％ (126/611),gallbladder polyps and cholecystitis18.66％ (114/611),elevated blood sugar 9.53％ (59/619).Dyslipidemia and abnormal of electrocardiogram were on the rise overall during the three years.Dyslipidemia was releated to sex and age,the number that plasma lipid of women aged from 55 to 64 reach appropriate level was lowest.Conclusions The faculty of vocational colleges have higher incidence of chronic diseases.Women group aged from 55 to 64 have highest incidence of dyslipidemia;more active,targeted measures need be taken.

Objective To evaluate the therapeutic effect of Kangbingdu oral liquid in combination with ribavirin aerosol for hand, foot, and mouth disease (HFMD). Methods A total of 135 HFMD children were enrolled and assigned to receive ribavirin aerosol alone (ontrol group, 67 patients) or ribavirin aerosol plus Kangbingdu oral liquid group (treatment group, 68 patients) for 7 days. Therapeutic effect was evaluated as the time to fever resolution, subsidence of skin rash and oral ulcers. All throat swab samples were tested using a fluorescence quantitative RT-PCR assay for panenteroviruses, enterovirus 71(EV71)and Coxsackievirus A16 (CA16). Results The time to fever resolution(2.51±0.42 d vs. 3.92±0.61 d;t=15.621, P<0.01), subsidence of skin rash(4.22±1.34 d vs. 6.33±1.41 d;t=8.914, P<0.01)and oral ulcers(3.01±0.32 d vs. 4.52±1.21 d;t=9.880, P<0.01)in the treatment group were significantly shorter than those in the control group. The healing rate in the treatment group were significantly higher than that in the control group(88.2%vs. 44.8%;χ2=26.761, P<0.01), and total effective rate was no different in treatment and control groups(94.1%vs. 83.6%;χ2=2.801, P=0.094). The rates of conversion from positive to negative for panenteroviruses(90.9% vs. 52.6%;χ2=13.331, P<0.01)and EV71(83.3%vs. 52.4%;χ2=4.307, P=0.038)in the treatment group were significantly higher than those in the control group, and the rate of conversion from positive to negative for CA16 was no different in treatment and control groups(93.3%vs. 81.8%;χ2=0.082, P=0.774). Conclusion Kangbingdu oral liquid in combination with ribavirin aerosol may improve the rate of conversion from positive to negative for enteroviruses, reduced the time to fever resolution, subsidence of skin rash and oral ulcers in HFMD children.

Objective To investigate the changes of thyroid hormones in pregnant women of different gestation by analyzing the test results from pregnant women .Methods Authors collected serum from 1 764 pregnant women and 121 healthy women(not pregnant ,control group) .And the levels of thyroid stimulating hormone(TSH) ,free triiodothyronine(FT3 ) and free thyroxine (FT4 ) in serum were tested by chemiluminescence microparticle immunization analysis(CMIA) method .Results The level of TSH (1 .06 mIU/L) in early-gestation women was lower than that in control group(P<0 .05) ,but increased in mid-gestation and late-gestation ,there was significant difference among early-gestation ,mid-gestation and late-gestation women(P<0 .05) .The levels of FT3 and FT4 in early-gestation women were higher than those in control group(P<0 .05) ,but decreased during mid-gestation and late-gestation ,there was significant difference among early-gestation ,mid-gestation and late-gestation women(P<0 .05) .Conclusion Thyroid hormones of pregnant women change in different gestation periods ,different reference values have to be adapted to evaluate thyroid gland function .

Objective To investigate the relationship between the autoantibody detection and abortion of pregnant women.Meth-ods The dot immunogold method,indirect immunofluorescence and enzyme-linked immunosorbent assay(ELISA)were used to de-tect serum anti-double stranded DNA antibody (dsDNA),anti-smooth muscle antibody (SMA),antinuclear antibody (ANA),anti-endometrial antibody (EMAb),anti-cardiolipin antibody(ACA),anti-sperm antibody (ASAb),anti-ovarian antibody(AoAb).Re-sults Compared with healthy pregnant women,the values of EMAb,ACA,AoAb,ANA and SMA in abortion pregnant women were increased with statistical differences (P <0.05).Conclusion EMAb,ACA,AoAb,ANA and SMA have high correlation with abortion of pregnant women.Confirming the causes of unexplained abortion and prenatal screening are especially important for the pregnant women in the border area.

Recently, double-hit lymphoma (DHL) was clarified to be a molecular category of B-cell lym-phoma, which was mainly related to MYC and Bcl-2 genes translocation. Fluorescence in situ hybridization (FISH) is the gold standard of diagnosis and it is controversial to detect the expression of MYC and Bcl-2 protein by immuno-histochemistry. DHL, which was found to be aggressive according to many retrospective analyses, mainly develops in patients with diffuse large B-cell lymphoma and grey zone lymphoma. Both rituximab combination and transplant consolidation were not able to signiifcantly overcome the poor prognosis of DHL. Novel and speciifc molecular targeted agents need to be explored and investigated in order to improve the treatment outcome.

The aim of joint development and sharing of institutional repository is to reveal and use the primary literature in military colleges and universities, and help scientific researchers, teachers and students to discover and use such re-sources .The ideas on joint development and sharing of institutional repository in military colleges and universities were thus analyzed, and the related problems were elaborated with suggestions put forward for their solution.

Objective:To discuss the curative effect of Saccharomyces boulardii Sachets in the treatment of children with hand-foot-mouth disease (HFMD) and explore the influence on serum procalcitonin (PCT) and interleukin-6 and 12 (IL-6 and 12) levels. Methods:Totally 88 cases of children with HFMD were selected and divided into the observation group and the control group at ran-dom. The children in the two groups were given routine medical treatment, such as anti-virus, defervesce, nutrition support and etc. The children in the observation group were additionally given 0. 25g Saccharomyces boulardii Sachets, once a day with warm boiled wa-ter. The changes in serum PCT, IL-6 and 12 levels of the children before and 72 hours after the medical treatment were observed, and the clinical curative effect and adverse reactions were compared as well. Results: After the 72-hour medical treatment, serum PCT, IL-6 and 12 levels of the children in the two groups were declined in different degrees (P<0. 05 or P<0. 01), and the declining rate in the observation group was much higher than that in the control group (P<0. 05). The total clinical efficiency of the observation group was also much higher than that of the control group. The adverse reactions appeared respectively in the control group and the ob-servation group during the medical treatment show no significant difference(P>0. 05). Conclusion:Saccharomyces boulardii Sachets used as adjunctive therapy show favorable curative effect and safety in the treatment of children with HFMD, which can reduce serum PCT, IL-6 and 12 levels, and inhibit the immune inflammatory reaction process in children.