China ; Dental Implants ; Health Services Needs and Demand ; Humans ; Periodontics ; manpower

Biomedical Research ; trends ; Humans ; Liver Neoplasms

In June 2004,the US Food and Drug Administration (FDA) issued Guidance for Industry:Botanical Drug Development,which opened a new path for the internationalization of traditional Chinese medicine (TCM).In October 2006,the first botanical drug product Veregen TM was approved by the FDA.The regulatory policy for botanical and herbal medicine coincides with the internationalization strategy of Hutchison MediPharma Ltd.(hereinafter referred to as Hutchison).In 2006,Hutchison's first herbal mixture medicine andrographis paniculata HMPL-004 successfully obtained Investigational New Drug (IND) from the US.From 2006 to 2014,there are eight clinical studies of HMPL-004 being conducted in Europe and the US,from Phase 1 safety study to proof-of-concept trials in ulcerative colitis (UC) and Crohn's disease.To strengthen HMPL-004 development on a global scale,Hutchison made business alliance with Nestle Health Science in clinical development as well as basic research.Due to futile outcome of an interim analysis,the Phase Ⅲ registration study in UC was terminated.However,valuable lessons were learned with the birth of the generation botanical drug product HMPL004-6599.

[Objective] To observe the effect of tea saponin purified by macro-reticular resins,optimize the technique conditions.[Method] To screen the best macro-reticular resin in terms of adsorption rate,capacity and desorption rate.Orthogonal test was used to observe the effect of pH,time,concentration and volume ratio of resin to solution on adsorption.[Result] YWD01G2 was best resin for adsorption.Its optimum conditions were pH6~7,time 8h,concentration 0.05g/mL,ratio 1:1.5.The saponin content reached 82.3% in elution of 50% ethanol.[Conclusion]Saponin content could be significantly promoted by macro-reticular resin adsorption.The technique was brief and practicable.

Objective To explore for mentally challenged children, their families after the implementation of com-munity-based management and care, the effect obtained performance.Methods Select mentally disabled children 150 ca-ses as the research object of this experiment, implement necessary community management intervention for children and to give the necessary family care, mainly include the children carry out health education, existence education and encourage children to participate in training activities, etc.Comparing the patient′s psychological state before and after the intervention and the quality of life scores.Results Before the intervention and post-intervention comparison found that children in ath-letic ability, the ability to understand the performance aspects of quality of life scores, and a very significant improvement (p<0.05).In terms of children with inner feelings, after giving intervention also received a significant effect, children with heart felt warm enough.Conclusion For the mentally challenged children, to give them the necessary community manage-ment and home care, improving the quality of life in children with intellectual disabilities and children with enhanced inner feelings, etc., have shown a very significant meaning, highlights the success of community management and family care Ap-plication significance.

The predominant type of head and neck cancer is head and neck squamous cell carcinoma (HNSCC), which needs more effective treatment. As a highly immunosuppressive malignancy, HNSCC has 3 major mechanisms including induction of immune tolerance, local immune evasion, and disruption of T-cell signaling. Immune checkpoint plays a critical role in the function of T-cell and rapid development has been achieved by inhibiting programmed cell death 1 (PD-1). As anti-PD1 humanized monoclonal antibodies, pembrolizumab and nivolumab have proven to be effective in the salvage treatment for recurrent or metastatic HNSCC, further investigation is awaited.

Objective To observe the curative resection of oxycodone hydrochloride controlled intravenous analgesia pump after treatment of cervical cancer (patient-controlled-intravenous analgesia, PCIA) and the adverse effect of pain.Methods March 2016 to February 2017 undergoing open radical resection of cervical cancer patients with 108 cases, were randomly divided into observation group(n=54) and control group(n=54), the observation group was given oxycodone hydrochloride injection intravenous patient-controlled analgesia pump, the control group were treated with Sufentanil Citrate Injection patient-controlled analgesia pump, anal exhaust time, contrast two groups of patients with adverse drug reactions and postoperative 6h, 12h, 24h, 48h (NRS Numeric Rating Scale, NRS) pain score.ResultsPain score: 12h observation group compared with the control group NRS pain score (P<0.05), with statistical difference, 6h, 24h, 48h time group NRS pain scores haveno statistical difference.Adverse reactions: in the observation group, 7 cases of nausea, vomiting in 6 cases, 2 cases of hypotension;control group 16 cases of nausea and vomiting in 14 cases, 1 cases of hypotension, 1 cases of skin allergy, 1 cases of dizziness, adverse reaction rates were significantly higher than the observation group (P<0.05), the difference was statistically significant.Exhaust time: observation group (2.93±0.63) days, the control group (2.76±0.61) days, no statistical significance.ConclusionOxycodone controlled intravenous analgesia pump for analgesia in patients with radical resection of cervical carcinoma after open surgery, with less adverse reactions.

According to the practical situation of School of public health,the establishment and management of experiment center were studied in different aspects of guiding ideology,management system,laboratory equipment and resources,experimental personnel,rules and regulations.

Foreign-invested hospitals are for-profit institutes built in China by MNCs(Multinational Corporations).The composition of human resources in Foreign-invested hospitals is the same as that in Foreign-invested companies in China,with the character of international human resources.Thus,this article reviewed some relevant theories on IHRM(International Human Resource Management)in the first place,and then discussed IHRM associated with the status quo of foreign-invested hospitals in China.

Objective:To investigate thc changes and clinical significance of antithrombin Ⅲin pregnancy induced hyperternsion(PIH),diabetes mellitus(DM),nephritic syndrome(NS),systemic lupus erythematosus(SLE) and acute non-lymphoid cell leukemia(ANLL).Methods:AT-Ⅲ:A was measured by chromogonic substratc method in pregnancy induced hypertension(PIH),diabetes mellitus(DM),nephritic syndrome(NS),systemic lupus erythematosus(SLE),acute non-lymphoid cell leukemia(ANLL) and control group.Results:AT-Ⅲ:A in women with PIH and normal prcgnancy and the DM with conplication and the NS and the SLE and the ANLL was significantly lower than that in the control.No significant difference in AT-Ⅲ:A was found between the DM without complication and the control.Conclusion:Determination of AT-Ⅲ:A has great value in the diagnosis of thrombophilia.