Objective To investigate the clinical value of combined tests,including A-fetus protein(AFP)、cancer embryo agent(CEA),carbonhydrate agent 19-9(CA19-9)for the diagnosis of malignant tumors in digestive system.Methods Chemicalill-umination tests were used to detect serum levels of AFP,CEA and CA 19-9 in 821 patients with diseases of digestive system.Results The levels of AFP,CEA,CA19-9 in malignant group and the benign group were significantly higher than the control group(t=2.345,2.224,all P＜0.05;t=2.785,2.749,2.897,2.865,all P＜0.01＝;The levels of AFP、CEA、CA19-9 in malignant group were significantly higher than benign group (t=2.445,P＜0.05;t=2.745,2.819,all P＜0.01);The level of AFP in liver cancer group was significantly hisher than other groups(t=2.715,2.812,2.877,2.845,2.799,all P＜0.01);The level of CEA in hver cancer group was significantly lower in patients with liver colorectal cancer and pancreatic cancer(t=2.775,2.801,all P＜0.01);The level of CA19-9 in bile duct cancer group was significantly hisher than that of other cancers (t=2.733,2.851,2.788,all P＜0.01);The positive rates of liver、stomach、colorectal cancer、pancreatic cancer、bile duct cancer combined detection in three item were 91.0%,90.0,88.0%,90.0%,70.2%which were higher than the single check-positive rate of 85.0%,72.0%,67.5%,79.4%、55.3%(χ2=3.781,3.841,3.798,3.814,3.994,all P＞0.05).Conclusion The three tumor markers could be used as auxiliary diagnostic and ioint detection which could improve the detection rate in patients with malignant tumors of digestive system.

Objective This study aimed to investigate the impact of different modes of treatments on depression,anxiety and quality of life in colorectal cancer patients.Methods The sample was comprised of 1 1 4 oncology patients and 67 partners of the oncology patients.All patients were diagnosed with colon cancer or rectal cancer.All of them accepted one of the three modes of treatments:surgery,surgery plus chemotherapy or surgery followed by radiotherapy.According to the treatments,the patients and their partners were divided into three groups.Anxiety and depression levels of the patients were evaluated with HADS,QOL-CA2.The depression level of their partners was evaluated with BDI.The evaluation results of the three groups were statistically analyzed.Results Anxiety and depression levels of colorectal cancer patients accepting different treatments were significantly different (P <0.05).Compared to the patients accepting only surgery,anxiety and depression levels of the patients accepting surgery plus chemotherapy and the patients accepting surgery followed by radiotherapy were significantly higher (P <0.05).Significant difference of anxiety and depression levels was not found between the patients accepting surgery followed by radiotherapy and the patients accepting surgery plus chemotherapy (P >0.05 ).No significant difference of anxiety and depression levels was found among the partners of the patients accepting different treatments (P >0.05 ).The higher the depression level of the patients were,the higher the depression level of their partners were.Anxiety and depression were the main predictors of patient′s quality of life.Conclusions This study highlights the importance of providing psychological interventions for cancer patients and their partners.The patients,who accept chemotherapy or radiotherapy and are diagnosed with cancer more than 1 2 months,are at high risk of anxiety and depression. Psychological interventions should be emphasized in these patients.