Objective To explore the risk factors of young patients with coronary heart disease ( CHD) , and the differences between the young patients and the elderly patients to provide a reference for the prevention of early CHD. Methods We retrospectively analyzed 437 cases of patients who came our hospital and had coronary artery bypass surgery from May 2009 to May 2012. The age of young people was less than 45 years wold patients (51 cases), and elderly patients (age greater than or equal to 65 years of age) were 386 cases. We compared and analyzed the indicators of the family history, lipid profile, blood glucose, blood pressure, heart function, postoperative infections, liver and kidney function, postoperative complications, between two groups of patients. Results Compared with the older patients, there were differences on the positive family history, smoking, obesity, dyslipidemia, cardiac function, angina classification, blood sugar, complications in young group (P<0. 05). Acute myocardial infarction was 33. 3% in young people, but it was 18. 1% in elderly patients (χ2 =2. 15,P<0. 05), old myocardial infarction was 7. 8% in young people, but it was 20. 7% in elderly patients (χ2 =2. 16,P<0. 05). Conclusions The major risk factors for CHD of young men are family history, smoking, being overweight, low HDL, high blood pressure, and the young patients would recovery faster than older patients after surgery. Early surgical treatment could prevent the occurrence of CHD and delay the progress.

Objective:To analyze the risk factors of bronchopulmonary dysplasia(BPD)in very preterm infants(VPI), and to provide scientific basis for the prevention and treatment of BPD in VPI.Methods:A prospective multicenter study was designed to collect the clinical data of VPI in department of neonatology of 28 hospitals in 7 regions from September 2019 to December 2020.According to the continuous oxygen dependence at 28 days after birth, VPI were divided into non BPD group and BPD group, and the risk factors of BPD in VPI were analyzed.Results:A total of 2 514 cases of VPI including 1 364 cases without BPD and 1 150 cases with BPD were enrolled.The incidence of BPD was 45.7%.The smaller the gestational age and weight, the higher the incidence of BPD( P<0.001). Compared with non BPD group, the average birth age, weight and cesarean section rate in BPD group were lower, and the incidence of male infants, small for gestational age and 5-minute apgar score≤7 were higher( P<0.01). In BPD group, the incidences of neonatal respiratory distress syndrome(NRDS), hemodynamically significant patent ductus arteriosus, retinopathy of prematurity, feeding intolerance, extrauterine growth restriction, grade Ⅲ~Ⅳ intracranial hemorrhage, anemia, early-onset and late-onset sepsis, nosocomial infection, parenteral nutrition-associated cholestasis were higher( P<0.05), the use of pulmonary surfactant(PS), postnatal hormone exposure, anemia and blood transfusion were also higher, and the time of invasive and non-invasive mechanical ventilation, oxygen use and total hospital stay were longer( P<0.001). The time of starting enteral nutrition, cumulative fasting days, days of reaching total enteral nutrition, days of continuous parenteral nutrition, days of reaching 110 kcal/(kg·d) total calorie, days of reaching 110 kcal/(kg·d) oral calorie were longer and the breastfeeding rate was lower in BPD group than those in non BPD group( P<0.001). The cumulative doses of amino acid and fat emulsion during the first week of hospitalization were higher in BPD group( P<0.001). Multivariate Logistic regression analysis showed that NRDS, invasive mechanical ventilation, age of reaching total enteral nutrition, anemia and blood transfusion were the independent risk factors for BPD in VPI, and older gestational age was the protective factor for BPD. Conclusion:Strengthening perinatal management, avoiding premature delivery and severe NRDS, shortening the time of invasive mechanical ventilation, paying attention to enteral nutrition management, reaching whole intestinal feeding as soon as possible, and strictly mastering the indications of blood transfusion are very important to reduce the incidence of BPD in VPI.