1.Etiological analysis of acute respiratory tract infection in Taizhou of Zhejiang Province from 2020 to 2021
Ziyi WANG ; Jian WENG ; Hongzhu WANG ; Ying SHENG ; Guixia LI ; Xikai CHEN ; Congcong LI ; Yaya GUAN ; Ying SHENG ; Weiwei SHEN
Shanghai Journal of Preventive Medicine 2022;34(7):638-641
ObjectiveWe examined the principal respiratory pathogens in patients with acute respiratory tract infection in Taizhou, Zhejiang Province during 2020‒2021 to provide evidence for prevention, diagnosis and treatment of acute respiratory tract infection. MethodsFrom September 2020 to August 2021, a total of 2 831 cases with acute respiratory tract infection were collected from two influenza sentinel surveillance hospitals in Taizhou, which had then received the examination of 22 respiratory pathogens by multiple fluorescence quantitative PCR. ResultsThe total positive rate of respiratory pathogens in 2 831 samples was 14.13%, among which enterovirus (7.77%) and respiratory syncytial virus (1.59%) were the principal pathogens. Except enterovirus, there was no significant difference in the positive rate of pathogens detected by gender(P>0.05). Moreover, there was significant difference in pathogens by age (P<0.05), with the highest positive rate in 0‒4 years(35.21%). There was also significant difference in pathogens by seasons (P<0.05), with the highest positive rate in summer(20.54%). ConclusionThe positive rate of acute respiratory tract infection decreases significantly, compared with that before the COVID-19 epidemic. The differences in the positive rate differ significantly by age and seasons. Comprehensive consideration of diverse factors before diagnosis and the utilization of multiple fluorescent quantitative PCR can quickly and effectively determine the pathogens in the early stage of infection. Our findings may provide certain support for the diagnosis and treatment of acute respiratory infections in the context of COVID-19 in Taizhou.
2.Mitochondrial protein IF1 is a potential regulator of glucagon-like peptide (GLP-1) secretion function of the mouse intestine.
Ying WANG ; Jiaojiao ZHANG ; Xinyu CAO ; Yaya GUAN ; Shuang SHEN ; Genshen ZHONG ; Xiwen XIONG ; Yanhong XU ; Xiaoying ZHANG ; Hui WANG ; Jianping YE
Acta Pharmaceutica Sinica B 2021;11(6):1568-1577
IF1 (ATPIF1) is a nuclear DNA-encoded mitochondrial protein whose activity is inhibition of the F