Objective To evaluate the effect of integrated traditional Chinese and western medicine on endothelial function in patients with hypertension. Methods Thirty patients were randomly divided into two groups-the treated group and the control group. The patients in the treated group were treated by integrated traditional Chinese and western medicine, and the patients in the control treated by felodipine sustained release tablets (Plendil). The base line of brachial angiobore and the change of vascular diameter at response to nitroglycerin and reactive hyperemia were detected by using ultrasonography. Results After the treatment with integrated traditional Chinese and western medicine, the inner diameter were significant improved (P 0.05). Conclusion Integrated traditional Chinese and western medicine can improve endothelial function in patients with hypertension. Ultrasonography is a simple and effective method to evaluate the brachial arterial endothelial function.