Objective : The study provided evidence for clinical prevention of colorectal cancer by analyzing the characteristics of recurrence after colorectal polypectom． Methods : According to the number of polyps during the second colonoscopy，patients were divided into multiple recurrence group ( ≥3) and non-multiple recurrence group (＜3) ．The characteristics and risk factors of polyp recurrence were analyzed. Results : The clinical data of 370 patients who underwent two colorectal polypectomy were retrospectively analyzed．In univariate statistical analysis， polyp size (P = 0. 033) ，polyp site (P = 0. 002) ，and polyp color (P = 0. 032) were the risk factors for multiple polyp recurrence．In multivariate regression analysis，the number of polyps detected at the first colonoscopy (P = 0. 001) and the polyp site (P = 0. 001) were independent risk factors for multiple recurrence． Conclusion Multi- ple polyps on the first colonoscopy and polyps in the distal colon indicate an increased risk of multiple recurrence.