Objective To investigate the relationship between IL-6-174C/G and-572C/G site gene polymorphism with nonvalvular atrial fibrillation(NVAF) as well as the national differences of interleukin-gene polymorphism between Kazak and Han nationality in Xinjiang region.Methods Seventy-nine Kazak patients of NVAF(Kazak NVAF group),78 Han patients with NVFA (Han NVAF group),75 Han cases of non-AF and 79 Kazak cases of non-AF were selected in Xinjiang region.The venous bloods were collected from extracting DNA.IL-6 gene-174G/C and-572C/G polymorphism in various groups were analyzed by adopting the PCR-RFLP technique.Results The allele frequency of IL-6-572G/C site G in the NVAF group was significantly higher than that in the control group(x2 =4.076,P＜0.05).The allele frequency of IL-6 gene-572 G/C site G had statistical difference between the NVAF group and the control group(OR=1.519,95 ％CI:I.087-2.122,P＜0.05),but the distribution difference between the Han and Kazak control groups had no statistical significance(P＞0.05);the advanced age ≥75 years old)(OR=6.468,95 ％CI:2.427-17.240) and left atrial dimension(OR =1.053,95 ％ CI:1.022-1.085) were the independent factors of AF occurrence;the left ventricular ejection fraction was a protective factor for preventing AF occurrence.The allele frequency of IL-6 gene 174G/C site C and G had no statistical difference among various groups(P＞0.05).Conclusion The allele of IL-6-572 G/C site G is a risk factor of genetic predisposition in NVAF.IL-6-174G/C site gene polymorphism has no relation with the susceptibility of AF.

OBJECTIVEThe aVR lead four steps is a new algorithm for differential diagnosis of wide QRS complex tachycardia (WCT). The study explores the clinical value of this new algorithm on differential diagnosis of WCT.

METHODSApplication of aVR lead four steps to analysis the electrocardiogram of patients with WCT proved by electrophysiological study. Every step's accuracy rate, sensitivity and specificity to differential diagnosis of ventricular tachycardia (VT) were calculated. The first step diagnosed VT according to presence of an initial R wave in the aVR lead. The second step diagnosed VT according to width of an initial r or q wave > 40 ms in the aVR lead. The third step diagnosed VT according to notching on the initial downstroke of a predominantly negative QRS complex in the aVR lead. The fourth step diagnosis VT according to ventricular activation-velocity ratio (Vi/Vt) in the aVR lead, Vi/Vt ≤ 1 suggested VT. Results derived from aVR lead four steps algorithm were compared with results derived from Brugada and Vereckei four steps algorithm.

RESULTSA total of 113 patients with WCT were analyzed (31 supraventricular tachycardia, SVT and 82 ventricular tachycardia, VT). The accuracy rate of differential diagnosis VT is 91.2%, sensitivity is 90.2% and specificity is 77.4%. The accuracy and sensitivity of the aVR lead four steps algorithm for differential diagnosis of WCT were superior to the Brugada Vereckei four steps algorithm (P < 0.05). The specificity of the Vereckei four steps algorithm was superior to aVR lead and Brugada four steps algorithm (P < 0.05), while the specificity of the aVR lead four steps algorithm was similar as Brugada four steps algorithm (P > 0.05).

CONCLUSIONSThe aVR lead four steps algorithm is associated with excellent accuracy rate, sensitivity for differential diagnosis of WCT. This algorithm is simple and could be easily learned and applied by physician.

Adolescent ; Adult ; Aged ; Algorithms ; Diagnosis, Differential ; Electrocardiography ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Sensitivity and Specificity ; Tachycardia, Supraventricular ; diagnosis ; physiopathology ; Tachycardia, Ventricular ; diagnosis ; physiopathology ; Young Adult

Objective To analyze the influencing factors of coronary artery lesions in patients with Ka-wasaki disease(KD)in Xinjiang.Methods A total of 1 500 KD patients who were treated in the First Affilia-ted Hospital of Xinjiang Medical University from December 2020 to December 2022 were selected as the re-search objects.According to whether coronary artery disease occurred,they were divided into two groups.886 patients with coronary artery lesions were included in the experimental group,and 614 patients without coro-nary artery lesions were included in the control group.Univariate and multivariate logistic regression analysis was used to analyze the risk factors of coronary artery lesions.Results The results of logistic regression anal-ysis showed that the duration of fever(＞10 d),high Gensini score,high level of N-terminal pro-brain natri-uretic peptide(NT-proBNP),C-reactive protein(CRP),total cholesterol(TC),low-density lipoprotein cho-lesterol(LDL-C)and triglycerides(TG)may be risk factors for coronary artery lesions(P＜0.05).Conclusion In clinical diagnosis and treatment,targeted intervention should be given as early as possible to prevent the occurrence of coronary artery lesions.