1. Current status of sperm banking for young cancer patients in Japanese nationwide survey
Asian Journal of Andrology 2018;20(4):336-341
This study aimed to ascertain the current status of Japanese sperm banking for young cancer patients. During 2015, we mailed the directors of 695 institutes where sperm cryopreservation might be performed with questionnaires requesting information on the number of patients, age, precryopreservation chemotherapy, semen analyses results and diagnoses, cryopreservation success rate, and causes of unsuccessful cryopreservation. Of these 695 institutes, 92 had cryopreserved sperm before chemotherapy within the study period. In all, 820 cancer patients (237 testicular, 383 hematological, 46 bone and soft tissue, 20 brain, and 134 other malignancy) consulted the responding institutes for sperm cryopreservation. Except for testicular tumor, the number of patients whose sperm was preserved before cancer treatment was low compared to that of young cancer patients. Approximately 20% of patients with malignancies other than testicular tumor underwent chemotherapy before cryopreservation. The success rate of cryopreservation in hematological malignancy was 82.5%, significantly lower than that of both the testicular cancer (93.6%) and other malignancy groups (95.6%) (P < 0.05). The primary reasons for preservation failure were azoospermia and poor semen quality. Patients with hematological malignancies had a higher rate of unsuccessful cryopreservation compared to those in other groups, possibly due to the large number of patients requesting sperm cryopreservation after chemotherapy induction. In Japan, information regarding sperm banking prior to cancer treatment appears to be lacking. Information regarding sperm preservation before chemotherapy should be provided to all Japanese oncologists.
2.An infertile patient with Y chromosome b1/b3 deletion presenting with congenital bilateral absence of the vas deferens with normal spermatogenesis.
Shinnosuke KURODA ; Kimitsugu USUI ; Kohei MORI ; Kengo YASUDA ; Takuo ASAI ; Hiroyuki SANJO ; Hiroyuki YAKANAKA ; Teppei TAKESHIMA ; Takashi KAWAHARA ; Haruka HAMANOUE ; Yoshitake KATO ; Yasuhide MIYOSHI ; Hiroji UEMURA ; Akira IWASAKI ; Yasushi YUMURA
Clinical and Experimental Reproductive Medicine 2018;45(1):48-51
We report the case of a 46-year-old Chinese male patient who visited our clinic complaining of infertility. Semen analysis revealed azoospermia, and azoospermia factor c region partial deletion (b1/b3) was detected using Y chromosome microdeletion analysis. Testicular sperm extraction was performed after genetic counseling. The bilateral ductus deferens and a portion of the epididymis were absent, whereas the remaining epididymis was expanded. Motile intratesticular spermatozoa were successfully extracted from the seminiferous tubule. On histopathology, nearly complete spermatogenesis was confirmed in almost every seminiferous tubule. To our knowledge, this is the first case report of b1/b3 deletion with a congenital bilateral absence of the vas deferens and almost normal spermatogenesis.
Asian Continental Ancestry Group
;
Azoospermia
;
Epididymis
;
Genetic Counseling
;
Humans
;
Infertility
;
Infertility, Male
;
Male
;
Middle Aged
;
Semen Analysis
;
Seminiferous Tubules
;
Spermatogenesis*
;
Spermatozoa
;
Vas Deferens*
;
Y Chromosome*
3.Successful onco-testicular sperm extraction from a testicular cancer patient with a single testis and azoospermia.
Shinnosuke KURODA ; Takuya KONDO ; Kohei MORI ; Kengo YASUDA ; Takuo ASAI ; Hiroyuki SANJO ; Hiroyuki YAKANAKA ; Teppei TAKESHIMA ; Takashi KAWAHARA ; Yoshitake KATO ; Yasuhide MIYOSHI ; Hiroji UEMURA ; Akira IWASAKI ; Yasushi YUMURA
Clinical and Experimental Reproductive Medicine 2018;45(1):44-47
Onco-testicular sperm extraction is used to preserve fertility in patients with bilateral testicular tumors and azoospermia. We report the case of a testicular tumor in the solitary testis of a patient who had previously undergone successful contralateral orchiectomy and whose sperm was preserved by onco-testicular sperm extraction. A 35-year-old patient presented with swelling of his right scrotum that had lasted for 1 month. His medical history included a contralateral orchiectomy during childhood. Ultrasonography revealed a mosaic echoic area in his scrotum, suggesting a testicular tumor. The lesion was palpated within the normal testicular tissue along its edge and semen analysis showed azoospermia. Radical inguinal orchiectomy and onco-testicular sperm extraction were performed simultaneously. Motile spermatozoa were extracted from normal seminiferous tubules under microscopy and were frozen. Eventual intracytoplasmic sperm injection using the frozen spermatozoa is planned. Onco-testicular sperm extraction is an important fertility preservation method in patients with bilateral testicular tumors or a history of a previous contralateral orchiectomy.
Adult
;
Azoospermia*
;
Fertility
;
Fertility Preservation
;
Humans
;
Infertility, Male
;
Male
;
Methods
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Microscopy
;
Orchiectomy
;
Scrotum
;
Semen Analysis
;
Seminiferous Tubules
;
Sperm Injections, Intracytoplasmic
;
Sperm Retrieval
;
Spermatozoa*
;
Testicular Neoplasms*
;
Testis*
;
Ultrasonography
4.Outcomes of the study of intracytoplasmic sperm injection (ICSI) and sperm motility with microdissection testicular sperm extraction.
Yuuka ARAI ; Hiroe UENO ; Mizuki YAMAMOTO ; Haruna IZUMI ; Kazumi TAKESHIMA ; Tomonari HAYAMA ; Hideya SAKAKIBARA ; Yasushi YUMURA ; Etsuko MIYAGI ; Mariko MURASE
Asian Journal of Andrology 2022;24(2):221-222
5.Current status of sperm banking for young cancer patients in Japanese nationwide survey.
Yasushi YUMURA ; Akira TSUJIMURA ; Hiroshi OKADA ; Kuniaki OTA ; Masahumi KITAZAWA ; Tatsuya SUZUKI ; Tosiyuki KAKINUMA ; Seido TAKAE ; Nao SUZUKI ; Teruaki IWAMOTO
Asian Journal of Andrology 2018;20(4):336-341
This study aimed to ascertain the current status of Japanese sperm banking for young cancer patients. During 2015, we mailed the directors of 695 institutes where sperm cryopreservation might be performed with questionnaires requesting information on the number of patients, age, precryopreservation chemotherapy, semen analyses results and diagnoses, cryopreservation success rate, and causes of unsuccessful cryopreservation. Of these 695 institutes, 92 had cryopreserved sperm before chemotherapy within the study period. In all, 820 cancer patients (237 testicular, 383 hematological, 46 bone and soft tissue, 20 brain, and 134 other malignancy) consulted the responding institutes for sperm cryopreservation. Except for testicular tumor, the number of patients whose sperm was preserved before cancer treatment was low compared to that of young cancer patients. Approximately 20% of patients with malignancies other than testicular tumor underwent chemotherapy before cryopreservation. The success rate of cryopreservation in hematological malignancy was 82.5%, significantly lower than that of both the testicular cancer (93.6%) and other malignancy groups (95.6%) (P < 0.05). The primary reasons for preservation failure were azoospermia and poor semen quality. Patients with hematological malignancies had a higher rate of unsuccessful cryopreservation compared to those in other groups, possibly due to the large number of patients requesting sperm cryopreservation after chemotherapy induction. In Japan, information regarding sperm banking prior to cancer treatment appears to be lacking. Information regarding sperm preservation before chemotherapy should be provided to all Japanese oncologists.
Adolescent
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Adult
;
Age Factors
;
Azoospermia
;
Cryopreservation
;
Drug Therapy
;
Humans
;
Japan/epidemiology*
;
Male
;
Middle Aged
;
Neoplasms/epidemiology*
;
Semen Analysis
;
Semen Preservation/methods*
;
Sperm Banks/statistics & numerical data*
;
Surveys and Questionnaires
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Testicular Neoplasms/epidemiology*
;
Treatment Outcome
;
Young Adult
6.Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility
Ashok AGARWAL ; Neel PAREKH ; Manesh Kumar PANNER SELVAM ; Ralf HENKEL ; Rupin SHAH ; Sheryl T HOMA ; Ranjith RAMASAMY ; Edmund KO ; Kelton TREMELLEN ; Sandro ESTEVES ; Ahmad MAJZOUB ; Juan G ALVAREZ ; David K GARDNER ; Channa N JAYASENA ; Jonathan W RAMSAY ; Chak Lam CHO ; Ramadan SALEH ; Denny SAKKAS ; James M HOTALING ; Scott D LUNDY ; Sarah VIJ ; Joel MARMAR ; Jaime GOSALVEZ ; Edmund SABANEGH ; Hyun Jun PARK ; Armand ZINI ; Parviz KAVOUSSI ; Sava MICIC ; Ryan SMITH ; Gian Maria BUSETTO ; Mustafa Emre BAKIRCIOĞLU ; Gerhard HAIDL ; Giancarlo BALERCIA ; Nicolás Garrido PUCHALT ; Moncef BEN-KHALIFA ; Nicholas TADROS ; Jackson KIRKMAN-BROWNE ; Sergey MOSKOVTSEV ; Xuefeng HUANG ; Edson BORGES ; Daniel FRANKEN ; Natan BAR-CHAMA ; Yoshiharu MORIMOTO ; Kazuhisa TOMITA ; Vasan Satya SRINI ; Willem OMBELET ; Elisabetta BALDI ; Monica MURATORI ; Yasushi YUMURA ; Sandro LA VIGNERA ; Raghavender KOSGI ; Marlon P MARTINEZ ; Donald P EVENSON ; Daniel Suslik ZYLBERSZTEJN ; Matheus ROQUE ; Marcello COCUZZA ; Marcelo VIEIRA ; Assaf BEN-MEIR ; Raoul ORVIETO ; Eliahu LEVITAS ; Amir WISER ; Mohamed ARAFA ; Vineet MALHOTRA ; Sijo Joseph PAREKATTIL ; Haitham ELBARDISI ; Luiz CARVALHO ; Rima DADA ; Christophe SIFER ; Pankaj TALWAR ; Ahmet GUDELOGLU ; Ahmed M A MAHMOUD ; Khaled TERRAS ; Chadi YAZBECK ; Bojanic NEBOJSA ; Damayanthi DURAIRAJANAYAGAM ; Ajina MOUNIR ; Linda G KAHN ; Saradha BASKARAN ; Rishma Dhillon PAI ; Donatella PAOLI ; Kristian LEISEGANG ; Mohamed Reza MOEIN ; Sonia MALIK ; Onder YAMAN ; Luna SAMANTA ; Fouad BAYANE ; Sunil K JINDAL ; Muammer KENDIRCI ; Baris ALTAY ; Dragoljub PEROVIC ; Avi HARLEV
The World Journal of Men's Health 2019;37(3):296-312
Despite advances in the field of male reproductive health, idiopathic male infertility, in which a man has altered semen characteristics without an identifiable cause and there is no female factor infertility, remains a challenging condition to diagnose and manage. Increasing evidence suggests that oxidative stress (OS) plays an independent role in the etiology of male infertility, with 30% to 80% of infertile men having elevated seminal reactive oxygen species levels. OS can negatively affect fertility via a number of pathways, including interference with capacitation and possible damage to sperm membrane and DNA, which may impair the sperm's potential to fertilize an egg and develop into a healthy embryo. Adequate evaluation of male reproductive potential should therefore include an assessment of sperm OS. We propose the term Male Oxidative Stress Infertility, or MOSI, as a novel descriptor for infertile men with abnormal semen characteristics and OS, including many patients who were previously classified as having idiopathic male infertility. Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants). Current treatment protocols for OS, including the use of antioxidants, are not evidence-based and have the potential for complications and increased healthcare-related expenditures. Utilizing an easy, reproducible, and cost-effective test to measure ORP may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose. With the increasing awareness and understanding of MOSI as a distinct male infertility diagnosis, future research endeavors can facilitate the development of evidence-based treatments that target its underlying cause.
Antioxidants
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Classification
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Clinical Protocols
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Diagnosis
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DNA
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Embryonic Structures
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Female
;
Fertility
;
Health Expenditures
;
Humans
;
Infertility
;
Infertility, Male
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Male
;
Membranes
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Ovum
;
Oxidants
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Oxidation-Reduction
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Oxidative Stress
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Reactive Oxygen Species
;
Reducing Agents
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Reproductive Health
;
Semen
;
Spermatozoa
;
Subject Headings
7.A case of obstructive azoospermia secondary to genitourinary tract infection caused by a prostatic utricle cyst.
Tomoki SAITO ; Mitsuru KOMEYA ; Kimitsugu USUI ; Shinnosuke KURODA ; Teppei TAKESHIMA ; Kunitomo TAKASHIMA ; Mario IKEDA ; Yoshihito KONDO ; Yasushi YUMURA
Asian Journal of Andrology 2022;24(5):558-559
Azoospermia
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Cysts
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Humans
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Male
;
Prostate
;
Prostatic Diseases
;
Saccule and Utricle
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Urethra