1.Medical Student Selection on the Standpoint from Applicants and Social Needs. Activities of the Committee on Student Selection, 1994-1996.
Isamu SAKURAI ; Mitsuaki HIRANO ; Kiyoshi ISHIDA ; Tadahiko Kozu ; Yasuo KAGAWA ; Nobuya HASHIMOTO ; Hayato HASEKURA ; Kensuke HARADA ; Hisashi MIHARA
Medical Education 1997;28(3):151-155
This is a report of the activities of the committee on medical student selection 1994-1996, particularly focused on the 15th Conference on Medical-Student Admission held 1996/8/31 with the subjects of social needs and influences upon high school education for the purpose of improving student selection system in Japan. We must consider how largely admission tests have being influenced high school students at the time of decision making, what medical schools they submit their applications to, and what ability the society or community requires physicians, for creating better system of evaluation for admission in Japan.
2.Studies of Relationship between Alcohol Intake and Health in Agricultural and Fishing Populations in Japan
Akiyoshi BANDO ; Tsuyoshi IMURA ; Hidenori NAKAGAWA ; Saburo USUTANI ; Masanobu NISHIMURA ; Takumi KAJIKAWA ; Kunio ISHIDA ; Tetsuo MORIMOTO ; Kazamitsu HIRAI ; Yasuo CHUMAN ; Akira HORIKAWA
Journal of the Japanese Association of Rural Medicine 1991;39(6):1101-1122
At institutions in 9 areas of all over Japan, epidemiological and clinical surveys and investigations have been performed on the relationship between alcohol drinking and health for inhabitants in agricultural and fishing villages. The ethanol cutaneous patch test showed about 40% ALDH2 defficiency in these subjects. There were remarkable defferences in the drinking behavior between these positive and negative 2 groups. Various factors affecting the drinking behavior of subjects are there congenital diathesis, sexual difference, natural and social differences as well as age and occupation. By drinking, various abnomalities have been observed in various indexes such as medical examinations namely, hepatic functions (γ-GTP, GOT, GTP, etc), lipids (HDL-C, TG, etc), circulating functions (blood pressure, pulse, etc), metabolisms (uric acid, blood sugar, etc), and pancreatic functions. Most of them are risk factors in adult diseases. Accordingly, through collective education for drinking, its effect can be observed earlier and it will be very important to educate individuals for health control.
3.An ex post facto evaluation of the 82nd and 83rd national examination for Physicians' license.
Masahiko HATAO ; Motokazu HORI ; Saichi HOSODA ; Atsuaki GUNJI ; Hiroshi HAMADA ; Nobuya HASHIMOTO ; Yasuo IDEZUKI ; Kiyoshi ISHIDA ; Hiraki MATSUEDA ; Taiichi SAITO ; Junichi SUZUKI ; Fumimaro TAKAKU ; Fumio YAMASHITA
Medical Education 1990;21(4):269-274
The 82 nd and 83 rd National Examination for Physicians' License, which were held in 1988 and 1989 respectively, were evaluated from question to question as well as in all the questions as a whole to set minimum pass scores and analysis “relevance” and “difficulty” in a matrix utilizing a modified Ebel's method.
The evaluators were teachers in different disciplines in nationwide medical schools and teaching hospitals and clinical trainees who had taken and passed the immediate past examinations.
Following data processing, the questionable and difficult questions were on the decrease compared with the preceding year, and it was tentatively concluded that the National Examinations have gradually improved year by year.
4.Further Improvement in the National Examination for Physicians' License in 1993. An Ex post facto Evaluation of the Recent National Examination for Physicians' License.
Masahiko HATAO ; Motokazu HORI ; Saichi HOSODA ; Tokuteru GUNJI ; Hiroshi HAMADA ; Nobuya HASHIMOTO ; Yasuo IDEZUKI ; Kiyoshi ISHIDA ; Kei MATSUEDA ; Taiichi SAITO ; Junichi SUZUKI ; Fumimaro TAKAKU ; Fumio YAMASHITA
Medical Education 1993;24(1):37-43
5.Combination Therapy with Rituximab and Temozolomide for Recurrent and Refractory Primary Central Nervous System Lymphoma.
Mineko MURAKAMI ; Takamitsu FUJIMAKI ; Shuichiro ASANO ; Hiroshi NAKAGUCHI ; Shoko M YAMADA ; Katsumi HOYA ; Kazuto YAMAZAKI ; Yasuo ISHIDA ; Akira MATSUNO
Yonsei Medical Journal 2011;52(6):1031-1034
High-dose methotrexate-based chemotherapy has extended survival in patients with primary central nervous system lymphoma (PCNSL). However, although salvage treatment is necessary in recurrent and refractory PCNSL, this has not been standardized. We herein describe the efficacy of a combination of rituximab and temozolomide (TMZ) in two consecutive patients with recurrent and refractory PCNSL. Based on the immunohistochemical study, case 1 had a non-germinal center B-cell-like (non-GCB) subtype, was positive for bcl-2 and negative for O6-methylguanine-DNA methyltransferase (MGMT). Case 2 was GCB subtype, bcl-2-, and MGMT+. Because of the positive expression of MGMT, interferon-beta was additionally given in case 2. Complete responses and partial responses were obtained after the third and fourth cycles of combination therapy, respectively. This was maintained for 12 months, with acceptable toxicity. The combination of rituximab and TMZ was effective in tumors with different immunohistochemical profiles. This combination therapy warrants further study in a larger population.
Aged
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Antibodies, Monoclonal, Murine-Derived/*therapeutic use
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Antineoplastic Agents/*therapeutic use
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Central Nervous System Neoplasms/*drug therapy
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Dacarbazine/*analogs & derivatives/therapeutic use
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Drug Therapy, Combination/*methods
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Humans
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Lymphoma/*drug therapy
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Male
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Middle Aged
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Neoplasm Recurrence, Local/drug therapy