1.The Necessity of Simulation Specialist
Tomoko Miyoshi ; Yoshimi Kozai ; Ueda Junko ; Yasuhiro Mandai ; Toshiko Yoshida ; Manabu Suno ; Naoki Shiba ; Mitsune Tanimoto
Medical Education 2014;45(5):378-380
Simulation specialist who masters simulators is important for a management of simulation center. Okayama university medical school started to train simulation specialists. Now simulation training are familiar in our university through the simulation specialists helps course directors.
2.Color stability of laboratory glass-fiber-reinforced plastics for esthetic orthodontic wires.
Toshihiro INAMI ; Yasuhiro TANIMOTO ; Naomi MINAMI ; Masaru YAMAGUCHI ; Kazutaka KASAI
The Korean Journal of Orthodontics 2015;45(3):130-135
OBJECTIVE: In our previous study, glass-fiber-reinforced plastics (GFRPs) made from polycarbonate and glass fibers were prepared for esthetic orthodontic wires using pultrusion. These laboratory GFRP wires are more transparent than the commercially available nickel-titanium wire; however, an investigation of the color stability of GFRP during orthodontic treatment is needed. Accordingly, in the present study, the color stability of GFRP was assessed using colorimetry. METHODS: Preparation of GFRP esthetic round wires (diameter: 0.45 mm [0.018 inch]) using pultrusion was described previously. Here, to investigate how the diameter of fiber reinforcement affects color stability, GFRPs were prepared by incorporating either 13-microm (GFRP-13) or 7-microm glass (GFRP-7) fibers. The color changes of GFRPs after 24 h, and following 1, 2, and 4 weeks of coffee immersion at 37degrees C, were measured by colorimetry. We evaluated the color stability of GFRPs by two evaluating units: the color difference (DeltaE*) and National Bureau of Standards (NBS). RESULTS: After immersion, both GFRPs showed almost no visible color change. According to the colorimetry measurements, the DeltaE* values of GFRP-13 and GFRP-7 were 0.73-1.16, and 0.62-1.10, respectively. In accordance with NBS units, both GFRPs showed "slight" color changes. As a result, there were no significant differences in the DeltaE* values or NBS units for GFRP-13 or GFRP-7. Moreover, for both GFRPs, no significant differences were observed in any of the immersion periods. CONCLUSIONS: Our findings suggest that the GFRPs will maintain high color stability during orthodontic treatment, and are an attractive prospect as esthetic orthodontic wires.
Coffee
;
Colorimetry
;
Esthetics
;
Glass
;
Immersion
;
Orthodontic Wires*
;
Plastics*
3.Role of interleukin-6 in orthodontically induced inflammatory root resorption in humans.
Ryuichi KUNII ; Masaru YAMAGUCHI ; Yasuhiro TANIMOTO ; Masaki ASANO ; Kunihiko YAMADA ; Takemi GOSEKI ; Kazutaka KASAI
The Korean Journal of Orthodontics 2013;43(6):294-301
OBJECTIVE: To determine the interleukin (IL)-6 levels in gingival crevicular fluid (GCF) of patients with severe root resorption after orthodontic treatment and investigate the effects of different static compressive forces (CFs) on IL-6 production by human periodontal ligament (hPDL) cells and the influence of IL-6 on osteoclastic activation from human osteoclastic precursor (hOCP) cells in vitro. METHODS: IL-6 levels in GCF samples collected from 20 patients (15 and 5 subjects without and with radiographic evidence of severe root resorption, respectively) who had undergone orthodontic treatment were measured by ELISA. The levels of IL-6 mRNA in hPDL cells and IL-6 protein in conditioned medium after the application of different uniform CFs (0, 1.0, 2.0, or 4.0 g/cm2 for up to 72 h) were measured by real-time PCR and ELISA, respectively. Finally, the influence of IL-6 on mature osteoclasts was investigated by using hOCP cells on dentin slices in a pit-formation assay. RESULTS: Clinically, the IL-6 levels were significantly higher in the resorption group than in the control group. In vitro, IL-6 mRNA expression significantly increased with increasing CF. IL-6 protein secretion also increased in a time- and magnitude-dependent manner. Resorbed areas on dentin slices were significantly greater in the recombinant human IL-6-treated group and group cultured in hPDL cell-conditioned medium with CF application (4.0 g/cm2) than in the group cultured in hPDL cell-conditioned medium without CF application. CONCLUSIONS: IL-6 may play an important role in inducing or facilitating orthodontically induced inflammatory root resorption.
Culture Media, Conditioned
;
Dentin
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Enzyme-Linked Immunosorbent Assay
;
Gingival Crevicular Fluid
;
Humans*
;
Interleukin-6*
;
Interleukins
;
Osteoclasts
;
Periodontal Ligament
;
Real-Time Polymerase Chain Reaction
;
RNA, Messenger
;
Root Resorption*