1) Of 3887 patients hospitalized in our surgical clinic during about 20 years from 1946 to 1966, 43% were patients with abdominal surgery, 20% with neuralgia or rheumatoid arthritis, 9.8% with injuries of four extremities, 9.6% with malignant diseases, and 5.8% with postoperative disturbances.
2) It was concluded by our clinical investigations and laboratory findings that postoperative early ambulation (walk from 3rd. postoperative day) with early thermal bathing (40-42°C, 5 minutes bath from 7th postoperative day) in about 520 patients with gastrectomy or cholecystectomy promoted their postoperative recovery. But it was noted that postoperative recovery with malignant was not always promoted by early ambulation with early bathing and so care must be taken of such postoperative patient.
3) Recently patients with postoperative disturbances have been gradually increasing in our clinic. Of 99 patients with postlaparotomy disorders, 78 of them were postoperative intestinal adhesion. 38 of which were not re-operated and were treated by hydrotherapy that diminished their complaints from 100% to 37.7% after average 48 day therapy.
4) 328 patients with lumbago and sciatica were treated combined with balneotherapy. Of 28 patients with lumbal disc hernia, 53.6%, healed, 46.4% were markedly improved after two month therapy. But, of 21 patients with postlaminectomy or postmyelogram disturbances, only 23.8% healed, 57.1% were improved and 19% were unchanged after two month therapy.
5) 380 patients with rheumatoid arthritis were treated by balneotherapy combined with intraarticular corticosteroid injection. When local improvement by these treatments was little, these patients were treated by means of such procedures as intraarticular pumping and washing, curettage of synovial membrane and fenesteration or partial synovectomy. Balneotherapy markedly improved operated joint function. R. A. patients were permitted to take thermal bathing 6-12 hours after intraarticular corticosteroid injection and there were no articular infection by bathing.

OBJECTIVESGlutathione S-transferase (GST) A1 catalyses the activated heterocyclic aromatic a mine carcinogenN-acetoxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OAc-PhIP). This case-control study was carried out to examine whether the genetic polymorphism of GSTA1 is associated with the risk oforal squamous cell carcinoma among Japanese people in relation to their smoking status.

METHODSIn this study, 97 Japanese oral squamous cell carcinoma patients and 457 healthy controls were compared for the frequencies of theGSTA1 genotypes ((*) A:-567T,-69C,-52G,(*) B:-567G,-69T,-52A).

RESULTSThe frequencies ofGSTA1 (*)A/(*)B+(*)B/(*) B genotypes were 32.3% in male cancer patients and 11.4% in female cancer patients, compared with 20.1% in the male control group (Odds ratio (OR)=1.86; 95% confidence interval (CI) 0.99-3.46) and 23.1% in the female control group (OR=0.58; 95% CI 0.18-1.81). TheGSTA1 (*)A/(*)B+(*)B/(*) B genotypes were associated with an 86% increased risk of oral squamous cell carcinoma among males, albeit without statistical significance. Also, among male smokers, the frequency ofGSTA1 (*)A/(*)B+(*)B/(*) B genotypes was significantly higher among the oral squamous cell carcinoma patients (33.3%) than among the controls (19.6%). The OR of the male smokers with theGSTA1 (*)A/(*)B+(*)B/(*) B genotypes for oral squamous cell carcinoma was 1.97 (95% CI 1.02-3.79).

CONCLUSIONSWe present the first evidence of an association betweenGSTA1 (*) B and oral squamous cell carcinoma among smokers. This study suggests that the GSTA1 polymorphism and tobacco smoke-derived PhIP are associated with oral squamous cell carcinoma susceptibility among male smokers.

BACKGROUND: Listeria monocytogenes (L. monocytogenes) is a rare causative pathogen of brain abscess that is often found in immunocompromised patients. Although patients with supratentorial listerial abscesses showed a longer survival with surgical drainage, the standard therapy for patients with subtentorial lesions has not been established. CASE REPORT: We report herein a patient with supra- and subtentorial brain abscesses caused by L. monocytogenes infection. These abscesses did not respond to antibiotics, and his symptoms gradually worsened. Drainage was not indicated for subtentorial lesions, and the patient was additionally treated with hyperbaric oxygen therapy, which dramatically reduced the volume of abscesses and improved the symptoms. CONCLUSIONS: This is the first report of drastic therapy for a patient with listerial brain abscesses involving combined antibiotics and hyperbaric oxygen therapy. The findings suggest that hyperbaric oxygen therapy is a good option for treating patients with deep-seated listerial abscesses and for who surgical drainage is not indicated.
Abscess ; Anti-Bacterial Agents ; Anti-Infective Agents* ; Brain Abscess* ; Drainage ; Humans ; Hyperbaric Oxygenation* ; Immunocompromised Host ; Listeria monocytogenes