OBJECTIVETo detect the expression of osteoclast related factors, tumor necrosis factor-alpha (TNF-alpha), receptor activator of NF-kappaB ligand (RANKL) and tartrate-resistant acid phosphatase (TRAP), in the process of bone remodeling.

METHODS8-week-old male C57BL/6J mice were employed in this study to detect the expression of osteoclast related factors by real time PCR.

RESULTSTNF-alpha, RANKL and TRAP were up regulated in the process of bone remodeling, they reached the peak on day 2, 5 and 10 individually after injury.

CONCLUSIONOsteoclast related factors also participate in bone remodeling, which depends on the delicate balance between bone formation and bone resorption.

Animals ; Bone Resorption ; Male ; Mice ; Mice, Inbred C57BL ; NF-kappa B ; Osteoclasts ; Osteogenesis ; RANK Ligand ; Receptor Activator of Nuclear Factor-kappa B ; Tumor Necrosis Factor-alpha