Objective To investigate the efficacy and safety of simultaneous prostate biopsy combined with greenlight laser photoselective vaporization of prostate(PVP)in the treatment of elderly,high-risk and suspected prostate cancer(PCa)patients.Methods A retrospective analysis was performed on 37 elderly,high-risk and suspected PCa patients in Tianjin union medical center between June 2018 and December 2022.The surgical time,laser time,postoperative bladder irrigation time,catheter retention time and perioperative complications were recorded respectively.Furthermore,the patients were followed up regarding the International Prostate Symptom Score(IPSS score),Quality of Life Score(QoL score),Maximum Urinary Flow Rate(Qmax)and Residual Urine Volume(PVR).Results All patients were treated with the surgery successfully,with a surgical time of 58(42,67)minutes and a laser time of 48(31,57)minutes.There were 1 case(2.7%)of capsule perforation,1 case(2.7%)of transfer to TURP,and no patients required blood transfusion.No patients had TUR syndrome(TURS),severe hematuria,urinary retention secondary surgery,new acute cardiovascular and cerebrovascular events in the perioperative period.Based on postoperative pathology,29 cases(78.4%)were PCa and 8 cases(21.6%)were benign prostatic hyperplasia.The IPSS[5(4,5)],Qol[2(2,3)],Qmax[16(14,18)mL/s],and PVR[30(24,35)mL]of all patients was improved significantly 12 months after the surgery.Besides,the tPSA level[0.05(0.02,0.37)μg/L]of PCa patients was also significantly decreased.Conclusion Simultaneous prostate biopsy combined with PVP can provide clear diagnosis and improve urinary tract obstruction,and is suitable for elderly,high-risk and suspected PCa patients.

Objective To evaluate the probability of siblings identification in Identifiler system by using the software of automatic analysis.Methods Using the software of automatic analysis in siblings jdentification.STP genetic typing of 151 pairs of full siblings and 31224 pairs of unrelated individuals from manual simulation were analyzed in 15 STR loci of ldentifiler system.Results Kin probability(W_(FS))of 39.07% full siblings were more than 99.999% while W_(FS) of unrelated individual pairs were 0% .W_(FS) of 60.93% full siblings and 21.3% unrelated individual pairs were all at the range from 99.999% to 1% .W_(FS) of 78.7% unrelated individual pairs 0% full siblings individuals were less than 1% .Therefore,there were notability difference between full siblings and unrelated individual pairs.In addition,testing of 15 STR loci of Identifiler system,it suggested that the pair were siblings when the locus number of the entirely-same is not less than 5 or that of the entirely-different is not more than 1,and that the pair were unrelated individuals when the locus number of the entirely-different is not less than 6 or that of the entirely-8alne is not more than 1.Conclusion The software of automatic analysis and the Identifiler system call be used to siblings identification.

Ureterosciatic hernia is a rare type of pelvic floor herniation with no typical symptoms. The resulting ureteral obstruction may lead to hydronephrosis and complications such as urinary tract infection and urosepsis.Fewer than 40 ureterosciatic hernia cases have been reported all over the world. Active surveillance, manual reduction, ureteral stenting and surgical repair are common treatment options. Among them, the safety and effectiveness of laparoscopic herniorrhaphy have been recognized. This article review the advances in the diagnosis and treatment of ureterosciatic hernia.