Objective To study the correlation of leptin,insulin-like growth factor-1 (IGF-1) and adiponectin in fetal cord blood with intrauterine growth retardation (IUGR).Methods Sixty-one fetus with IUGR were enrolled into the observation group and eighty healty fetus were enrolled into the control group.Leptin,IGF-1 and adiponectin were detected.Results The levels of leptin,IGF-1 and adiponectin in the observation group were lower than those in the control group,there were significant differences between the two groups (t =11.239,11.680,13.640,all P ＜ 0.01).The body mass in the observation group was (2 157 ± 243) g,which had significantly positive correlation with leptin (r =0.274,P ＜ 0.05),IGF-1 (r =0.532,P ＜ 0.05) and adiponectin (r =0.539,P ＜ 0.05).Conclusion There was a close relationship in leptin,IGF-1 and adiponectin with IUGR.

AIM: To establish the optimum preparation process for Bupleurum dropping pill. METHODS: A series of signal tests have been studied for the choice of substrate、 its proportion of substrate to drug、 the dropping and cooling agent temperature and dropping speed to make average pill weight,weight variation and roundness up to grade. RESULTS: The best pills formatting process were a ratio of PEG4000 to PEG6000(3∶1). CONCLUSION: This preparation method is suitable for both the laboratory test and the industrial production for Bupleurum dropping pill.

Objective To analyze the changes in body size of Chinese newborns in nine cities during 1975-2005.Methods The data of weight,height and head circumference of newborns within 3 days after birth from four national physical growth surveys named “a national survey on growth of children under seven years of age in nine cities of China” in 1975,1985,1995 and 2005 were used.The investigation areas were urban and suburban areas of Beijing,Harbin and Xi'an in the northern part;Shanghai,Nanjing and Wuhan in the central part; Guangzhou,Fuzhou and Kunming in the southern part of China.Random cluster sampling method was used,7325,6660,7109 and 6144 healthy newborns were examined in 1975,1985,1995 and 2005,respectively.The changes of body size between 1975 and 2005,urban-suburban difference and regional difference were compared with u test,ANOVA or x2 test.Results(1)The average weight had increased during the past 30 years no matter boys and girls,from urban and suburban areas.The increments was 40 ～ 100 g.The percentiles of weight had also increased and the distribution had shifted noticeably towards heavier weights.The proportion of macrosomia had increased from 3.2％(212/6660)in 1985 to 4.3％(265/6144)in 2005.(2)The length of newborns remained unchanged over the 30-year period no matter boys and girls,from urban and suburban areas.Head circumference of newborns showed only a minor increase(0.1～0.3 cm).(3)Ponderal index(PI)had increased gradually from 1975 to 2005.The means of PI had increased from 25.4 kg/m3 in 1975 to 26.0 kg/m3 in 2005.(4)Body size of urban newborns was slightly bigger than that of suburban newborns.The urban-suburban difference of weight and height became smaller and smaller in the 30 years,while the urban-suburban difference in PI became slightly bigger in 2005.(5)Weight,height and head circumference of newborns in northern and central areas were higher than those of southern newborns and the regional difference had not significant changes in the 30 years.The PI of newborns in northern and central areas was higher than that of southern part in 1975,while the PI of southern part became the highest in 2005.Conclusions The body size of newborns became slightly bigger and the proportion of macrosomia increased between 1975 and 2005.The urban-suburban difference became smaller and the regional difference remained in the 30 years.

Objective To investigate the expression of aromatase cytochrome P450 (P450arom), the secretion of estradiol and the suppressive effect of aromatase inhibitor letrozole on the proliferation of uterine leiomyoma cells in vitro. Methods Uterine leiomyoma cells were cultured in vitro, after the action of letrozole with different concentration, MTT was used to examine the proliferative activity of uterine leiomyoma cells, RT-PCR and immunocytochemistry was used to determine the expression of the P450arom protein and mRNA, and the concentration of estradiol in media supernatant was measured by radioimmunity. Results Low dosage (0.06 μmol/L) of letrozole had no effect on the expression of P450arom protein and mRNA, and estradiol synthesis in uterine leiomyoma cell (P>0.05). However, high dosage(0,6-6 μmol/L) of letrozole could down-regulate the expression of P450arom, and to inhibit estradiol synthesis and the proliferation activity of uterine leiomyoma cells(P<0.05). Furthermore, the inhibition were shown to decline gradually along with the increase in the concentrations of letrozole. Conclusion The aromatase inhibitor letrozole could suppress the proliferation of uterine leiomyoma cells in the dosage-dependent manner by down-regulating the expression of the P450arom and decreasing the estradiol synthesis, suggesting that the drug may possibly be effective in the clinical treatment of uterine leiomyoma.

Objective To investigate the prevalence of lower urinary tract symptoms in women in a community in Fuzhou. Methods We designed a patient-completed questionnaire according to Bristol Female Lower Urinary Tract Symptoms (BFLUTS) questionnaire.A few parts of the questionnaire were adjusted based on living habits and social backgrounds in our country.The health care workers distributed and collected the questionnaires and instructed the women to fill in them one by one. Results A total of 6066 questionnaires were distributed and 5587 were collected. Of the responders 4745 women were more than 18 years. The prevalence of stress incontinence, urgency incontinence,urgency,frequency and nocturia were 9.0% (425/4745),2.4% (113/4745),10.3% (489/4745),1.5% (72/4745) and 9.8% (446/4745),respectively.The prevalence of storage symptoms increased with age,showing a 20.5%(104/507) in 18~27 years’ group,19.1% (332/1740) in 28~37,22.5%(338/1503) in 38~47,32.2%(202/628) in 48~57,41.2%(61/148) in 58~64,58.0% (127/219) in ≥65 years’ group. The overall prevalence was 24.5%.The prevalence of delayed urinary,intermittent stream,increased abdominal urination, incomplete emptying and voiding pain were 7.0%(330 cases),4.1%(194),4.6% (217),4.9% (233) and 4.8%(229),respectively.The prevalence of general voiding dysfunction increased with age,showing a 13.0% (66/507) in 18~27 years’ group,9.3% (162/1740) in 28~37,10.7%(161/1503) in 38~47,13.2%(83/628) in 48~57,16.2% (24/148) in 58~64 and 26.9%(59/219) in ≥65 years’ group.The overall prevalence was 11.7%. Conclusions The prevalence of lower urinary tract symptoms are high in community-dwelling women,and the prevalence of storage symptoms are more common than that of voiding dysfunction in these women.

Objective:To investigate the effect of Caprini risk score-based care on the prevention of venous thromboembolism of patients with major orthopedic surgery.Methods:Totally 124 patients with major orthopedic surgery were randomly divided into experimental group and control group, each group contained 62 cases. The control group received routine thrombosis prevention nursing, patients in the experimental group carried out Caprini risk score-based intervention. The rate of VTE was compared between two groups, the levels of D-Dimer as well as thigh circumference was measured after 24 hours of admission, 3 days after surgery, 5 days after surgery and at discharge day. At discharge day, the inpatients satisfaction with nursing service scale was used to assessment the satisfaction with nursing service of inpatients.Results:The rate of VTE in the experimental group was 1.6% (1/62) and 6.5% (4/62) in the control group, the difference was not statistically significant ( χ2 value was 1.876, P=0.171). Three days after surgery, 5 days after surgery and at discharge day, the D-Dimer were (1.26±0.65) μg/ml, (1.27±0.35) μg/ml, (0.96±0.27) μg/ml in the experimental group, 5 days after surgery and at discharge day, the thigh circumference were (29.81±4.15) cm, (28.86±3.40) cm in the experimental group, significantly lower than those in the control group [(1.64±0.58) μg/ml, (1.51±0.55) μg/ml, (1.25±0.44) μg/ml, (31.84±5.22) cm, (30.83±3.91) cm], the difference was statistically significant ( t value was 2.405-4.485, P<0.05). The health education and guidance, personality traits, service quality, discharge guidance scores and total satisfaction scores were 26.31±3.06, 35.73±3.64, 27.89±3.11, 8.47±1.18 and 111.08±6.33, significantly higher than those in the control group (24.15±2.31, 33.92±2.66, 26.27±3.41, 7.42±1.82 and 106.52±5.85), the difference was statistically significant ( t value was 2.750-4.433, P<0.05). Conclusions:Caprini risk score-based nursing care significantly alleviates the hypercoagulable states and relieves the degree of swelling of the affected of patients with major orthopedic surgery, as well as improves patients' satisfaction with nursing work.

Objective To investigate the effect of establishing external device quality management system in the operating room of primary hospital.Methods 100 pieces external orthopaedic surgical instrument cleaned and packaged by company personnel in 2012 were randomly selected as control group,and 100 packages of orthopaedic surgical instrument cleaned by the professional of our hospital were randomly selected and set as the observation group.The cleaning quality of the two groups were compared.Results The numbers of no blood on the surface,sur-face of the device without rust,instrument storage box no stains,cloth bag no stains in the control group were 92,91, 86,90,respectively,which in the observation group were 99,98,97,98.The cleaning quality improved obviously in the observation group,and there were statistically significant differences between the two groups (χ2 =4.19,471,7.78, 5.67,all P <0.05).Conclusion To establishment of surgical patients external device quality management system in the operating room of primary hospital,standardized management of external devices,can ensure that the management and implementation of quality control of external devices in all aspects and to ensure clinical safety.

OBJECTIVE To probe the possibility for CQI to raise the passing rate of hand-washing liquid. METHODS From Jul 2007 to Sep 2007,we applicated continuous quality improvement(CQI) in the management of the use of hand-washing liquid. RESULTS The failure rate of hand-washing liquid was decreased markedly (64% in July,36% in August,and in 12%September),and the difference among three months was significant (P

OBJECTIVE To investigate the hand hygiene situation of medical staff in order to carry out supervising and monitoring on their hand hygiene pertinently.METHODS The hand hygiene monitoring data from Jan 2004 to Dec 2007 were retrospectively analyzed.RESULTS The total qualified rate of medical staff hand hygiene was 91.4%;the qualified rate of hand hygiene monitoring for doctors was 89.8%,and it was 96.7% for nurses;the qualified rate of medical staff working in the type-Ⅱenvironment was 93.6%,and the qualified rate of those working in the type-Ⅲ environment was 95.2%;for medical students and refresher doctors,it was 81.0 %.CONCLUSIONS The medical staff still lack the knowledge on hands' cleanliness and disinfection.The supervisors should strengthen monitoring on hand hygiene;some new regulations should be established and practiced,and the hand washing equipments should be updated;the medical staff's compliance of hand hygiene should be improved,and their conceptions of hand hygiene should be strengthened;all-sided originalities on hand hygiene should be carried out in order to reduce the occurring of hospital infections.

0.05).Conclusions Special protein gold measuring instrument had high sensitivity,good accuration and speediness,which was suitable for clinical LAB to test CRP.