ObjectiveTo evaluate the clinical efficacy of foot therapy in intervening sleep disorder and improving sleep quality in breast cancer during chemotherapy.MethodTotally 120 eligible patients were randomized into a treatment group and a control group, 60 in each group. The treatment group was intervened by Chinese medicinal steaming washing plus acupoint application, while the control group was by conventional treatment. The effects on sleep quality and sleep duration were observed and compared. ResultThe total effective rate was 68.3% in the control group versus 90.0% in the treatment group, and the difference was statistically significant (P<0.05). The sleep quality, sleep duration, sleep disturbance, and Pittsburgh Sleep Quality Index (PSQI) score in the treatment group were more significantly improved than those in the control group after treatment (P<0.05).Conclusion Foot therapy can obviously improve the sleep quality of breast cancer patients during chemotherapy, and reduce the occurrence rate of sleep disorder during chemotherapy.

Objective To study the correlation of leptin,insulin-like growth factor-1 (IGF-1) and adiponectin in fetal cord blood with intrauterine growth retardation (IUGR).Methods Sixty-one fetus with IUGR were enrolled into the observation group and eighty healty fetus were enrolled into the control group.Leptin,IGF-1 and adiponectin were detected.Results The levels of leptin,IGF-1 and adiponectin in the observation group were lower than those in the control group,there were significant differences between the two groups (t =11.239,11.680,13.640,all P ＜ 0.01).The body mass in the observation group was (2 157 ± 243) g,which had significantly positive correlation with leptin (r =0.274,P ＜ 0.05),IGF-1 (r =0.532,P ＜ 0.05) and adiponectin (r =0.539,P ＜ 0.05).Conclusion There was a close relationship in leptin,IGF-1 and adiponectin with IUGR.

The FactorⅫ(FXII or a-Ⅻa)in Cohn's FIV was adsorbed by diato- mite,and then the FXⅡ(or ?-Ⅻa) was activated into ?-Ⅻa(Hageman factor fragment,PKA,MW31000)by the co-adsorbed kallikrein with sub- sequent releasing it toabuffer solu- tion.Finally,the product was purified by DEAE-Sephadex A_(50).The activity of prepared PKA was 8 963IU/ml,and the preparation can lead to signifi- cant reduction in blood pressure in rats.

Diabetes mellitus is poly-genetic inherited disease, which is influenced by both genes and environment. The environment may increase the susceptibility of diabetes mellitus via epigenetic way. While those from the same paternal and maternal imprinted genes in the role of offspring are not identical. Adverse intrauterine environment can be regarded as an integral part of the environment, therefore, intrauterine growth retardation may cause fetal epigenetic changes, which are also called imprinted genes. This paper will introduce the latest researches of the diabetes mellitus or insulin resistance-related imprinted genes,for example,GLUT4, IGF-2/H19,PGC-1 α and so on, to explore the relevant therapeutic targets of diabetes mellitus or insulin resistance at the level of epigenetics.

AIM: To establish the optimum preparation process for Bupleurum dropping pill. METHODS: A series of signal tests have been studied for the choice of substrate、 its proportion of substrate to drug、 the dropping and cooling agent temperature and dropping speed to make average pill weight,weight variation and roundness up to grade. RESULTS: The best pills formatting process were a ratio of PEG4000 to PEG6000(3∶1). CONCLUSION: This preparation method is suitable for both the laboratory test and the industrial production for Bupleurum dropping pill.

Tumor marker research is a hot field of oncology.Previous studies of tumor markers such as placental alkaline phosphatase,alpha-fetoprotein,c-kit and CD30 and so on,lack sufficient sensitivity and specificity for the early diagnosis of germ cell tumor.Recent research demonstrated that octamer-binding transcription factor 4 (OCT4),sal-like gene 4 (SALL4) can be used as new germ cell tumor markers.This paper reviewed the research progress on the OCT4 and SALL4 in recent years,to provide the reference about the early diagnosis,tumor typing,condition estimation,prognosis and targeted therapy of germ cell tumors.

The ventricular myocardial lactic dehydrogenase (LDH) and succinic dehydrogenase (SDH) were histochemically studied in 34 rabbits which were divided into 3 groups—normal control, sham operation and hemorrhagic shock. Using microspectrophotometric quantitative analysis showed that LDH activity was somewhat increased while SDH activity was obviously decreased (P

For the patients with early breast cancer,the effects of breast-conserving surgery combined with radiotherapy and radical resection are equal,and the former shows less adverse reactions and better aes-thetic outcome. Because of individual differences and the inherent complexity of tumor,to obtain optimal effects,it is an inevitable trend of making an individual comprehensive therapy,which is a combination of radiotherapy,chemotherapy,endocrine therapy and targeted therapy.

Objective To investigate the efficacy of wax therapy plus functional training in treating ankylosing spondylitis. Method One hundred patients were randomly allocated to treatment and control groups, 50 cases each. The treatment group received wax therapy plus functional training and the control group, functional training alone. One course of treatment consisted of seven days in both groups. The therapeutic effects clinical were evaluated after two course of treatment. Result Joint pain severity and morning stiffness time improved in both groups after treatment (P＜0.05 or P＜0.01) and did more in the treatment group than in the control group (P＜0.01). The total efficacy rates in the two groups were 84.0%and 66.0%, respectively;there was a statistically significant difference between the two groups (P＜0.05). Conclusion Wax therapy plus functional training is safe, reliable, convenient and easy to perform in clinical treatment of ankylosing spondylitis.