Diabetes mellitus is poly-genetic inherited disease, which is influenced by both genes and environment. The environment may increase the susceptibility of diabetes mellitus via epigenetic way. While those from the same paternal and maternal imprinted genes in the role of offspring are not identical. Adverse intrauterine environment can be regarded as an integral part of the environment, therefore, intrauterine growth retardation may cause fetal epigenetic changes, which are also called imprinted genes. This paper will introduce the latest researches of the diabetes mellitus or insulin resistance-related imprinted genes,for example,GLUT4, IGF-2/H19,PGC-1 α and so on, to explore the relevant therapeutic targets of diabetes mellitus or insulin resistance at the level of epigenetics.

Objective To study the correlation of leptin,insulin-like growth factor-1 (IGF-1) and adiponectin in fetal cord blood with intrauterine growth retardation (IUGR).Methods Sixty-one fetus with IUGR were enrolled into the observation group and eighty healty fetus were enrolled into the control group.Leptin,IGF-1 and adiponectin were detected.Results The levels of leptin,IGF-1 and adiponectin in the observation group were lower than those in the control group,there were significant differences between the two groups (t =11.239,11.680,13.640,all P ＜ 0.01).The body mass in the observation group was (2 157 ± 243) g,which had significantly positive correlation with leptin (r =0.274,P ＜ 0.05),IGF-1 (r =0.532,P ＜ 0.05) and adiponectin (r =0.539,P ＜ 0.05).Conclusion There was a close relationship in leptin,IGF-1 and adiponectin with IUGR.

ObjectiveTo evaluate the clinical efficacy of foot therapy in intervening sleep disorder and improving sleep quality in breast cancer during chemotherapy.MethodTotally 120 eligible patients were randomized into a treatment group and a control group, 60 in each group. The treatment group was intervened by Chinese medicinal steaming washing plus acupoint application, while the control group was by conventional treatment. The effects on sleep quality and sleep duration were observed and compared. ResultThe total effective rate was 68.3% in the control group versus 90.0% in the treatment group, and the difference was statistically significant (P<0.05). The sleep quality, sleep duration, sleep disturbance, and Pittsburgh Sleep Quality Index (PSQI) score in the treatment group were more significantly improved than those in the control group after treatment (P<0.05).Conclusion Foot therapy can obviously improve the sleep quality of breast cancer patients during chemotherapy, and reduce the occurrence rate of sleep disorder during chemotherapy.

Tumor marker research is a hot field of oncology.Previous studies of tumor markers such as placental alkaline phosphatase,alpha-fetoprotein,c-kit and CD30 and so on,lack sufficient sensitivity and specificity for the early diagnosis of germ cell tumor.Recent research demonstrated that octamer-binding transcription factor 4 (OCT4),sal-like gene 4 (SALL4) can be used as new germ cell tumor markers.This paper reviewed the research progress on the OCT4 and SALL4 in recent years,to provide the reference about the early diagnosis,tumor typing,condition estimation,prognosis and targeted therapy of germ cell tumors.

The ventricular myocardial lactic dehydrogenase (LDH) and succinic dehydrogenase (SDH) were histochemically studied in 34 rabbits which were divided into 3 groups—normal control, sham operation and hemorrhagic shock. Using microspectrophotometric quantitative analysis showed that LDH activity was somewhat increased while SDH activity was obviously decreased (P

The FactorⅫ(FXII or a-Ⅻa)in Cohn's FIV was adsorbed by diato- mite,and then the FXⅡ(or ?-Ⅻa) was activated into ?-Ⅻa(Hageman factor fragment,PKA,MW31000)by the co-adsorbed kallikrein with sub- sequent releasing it toabuffer solu- tion.Finally,the product was purified by DEAE-Sephadex A_(50).The activity of prepared PKA was 8 963IU/ml,and the preparation can lead to signifi- cant reduction in blood pressure in rats.

AIM: To establish the optimum preparation process for Bupleurum dropping pill. METHODS: A series of signal tests have been studied for the choice of substrate、 its proportion of substrate to drug、 the dropping and cooling agent temperature and dropping speed to make average pill weight,weight variation and roundness up to grade. RESULTS: The best pills formatting process were a ratio of PEG4000 to PEG6000(3∶1). CONCLUSION: This preparation method is suitable for both the laboratory test and the industrial production for Bupleurum dropping pill.

In vitro and in vivo animal model experiments have found that salidroside has protective effect for various causes induced injuries in various neurons and brain tissue.Its mechanisms of neuroprotection are multiple:(1)Protecting neurons from apoptotic injury by resisting oxidative stress,preventing intracellular Ca2 + overload,inhibiting caspase-3 activation,and attenuating hypoxia-induced abnormal metabolism of amyloid precursor protein;(2)promoting directional differentiation of stem cells into neurons and inducing neuronal regeneration;(3)promoting erythropoietin stimulating erythroblasts to be differentiated into erythrocytes and decreasing cerebrovascular resistance,and improving cerebral hypoxia-ischemia.Salidroside is expected to be used in the prevention and treatment of cerebral ischemic and neurodegenerative diseases,such as cerebral infarction,Alzheimer's disease,Parkinson's disease,amyotrophic lateral sclerosis,and diabetic encephalopathy.

Malignant tumors and the relative medical treatment of western medicine greatly affect the quality of life. This paper described the history and current situation of using acuponcture treating malignant tumor, and pointed out predominance of traditional Chinese medicine in treating tumor is treament based on syndrome differentiation and treatment according to the time of a day, which provides new ideas for acupuncture treatment of malignant tumors.