Objective To explore the effectiveness and esophageal strictures of concurrent chemoradiotherapy in patients with cervical and upper-thoracic esophageal cancer (EC) and middle-thoracic and lower-thoracic EC.Methods Between January 2011 and December 2014,ninety patients with different parts of EC were treated with radiotherapy combined with concurrent chemotherapy in People's Hospital of Subei.The median irradiation dose was 60 Gy.The chemotherapy regimens consisted of Paclitaxel and Nedaplatin.Of all the patients,48 patients had cervical and upper-thoracic EC,42 patients had middle-thoracic and lowerthoracic EC.The response rates,the local control rates,the survival rates and esophageal strictures were evaluated between two groups.Results The follow-up rate was 100％.The response rates of the patients with cervical and upper-thoracic EC and middle-thoracic and lower-thoracic EC were 81.2％ and 73.8％ (x2 =0.717,P =0.397),respectively.The 1-year local control rates of the patients with cervical and upper-thoracic EC and middle-thoracic and lower-thoracic EC were 90.3％ and 71.8％ (x2 =5.865,P =0.015),respectively.The 1-year survival rates of the patients with cervical and upper-thoracic EC and middle-thoracic and lower-thoracic EC were 87.5％ and 69.0％ (x2 =4.580,P =0.032),respectively.The moderate-to-severe esophageal strictures rates of the patients with cervical and upper-thoracic EC and middle-thoracic and lower-thoracic EC were 55.6％ and 29.4％ (x2 =5.360,P =0.021),respectively.There were no significant differences in shortterm effects between the cervical and upper-thoracic EC and middle-thoracic and lower-thoracic EC.The patients with cervical and upper-thoracic EC showed significantly higher 1-year local control rates,1-year survival rates and esophageal strictures rates than those with middle-thoracic and lower-thoracic EC.Conclusion The effectiveness of concurrent chemoradiotherapy is better in the patients with cervical and upper-thoracic EC than in those with middle-thoracic and lower-thoracic EC,but the esophageal stenosis is more severe in the patients with cervical and upper-thoracic EC than in those with middle-thoracic and lower-thoracic EC.

Objective To explore the change of monocyte chemotactic factor-1 protein(MCP-1)and matrix metalloproteinase-9( MMP-9)of patients with coronary artery disease( CAD)following percutaneous coronary interventional( PCI). Methods Fifty patients underwent PCI procedures for CAD compromising a single coronary artery were selected as PCI group and 30 healthy individuals with normal findings by coronary angiography were selected as the control group. Plasma MCP-1 and MMP-9 were measured in all the subjects. Results The plasma MCP-1 level of patients with CAD after PCI was(19. 87 ± 5. 31)ng/ L,higher than that before operation((15. 71 ± 5. 23)ng/ L,t = 3. 95,P < 0. 01). Whereas in the control group,the MCP-1 level after coronary angiography was(13. 78 ± 5. 58)ng/ L,which was as same as that before operation (12. 42 ± 5. 39 ng/ L,P = 0. 34). Plasma MMP-9 level in the CAD patients after PCI procedures was(22. 69 ± 5. 97)mg/ L,higher than that before operation((19. 52 ± 5. 72)mg/ L,t = 2. 71,P < 0. 01). There was no significant difference in term of plasma MMP-9 level in control group befor and after operation((17. 53 ± 5. 51) mg/ L vs.(16. 69 ± 5. 42)mg/ L,P = 0. 55). Conclusion Plasma MCP-1 and MMP-9 increase in CAD patients following PCI procedures. But their roles in the vascular restenosis following the procedures need further investigation.

Background: The testis has been reported to be a naturally O 2 -deprived organ, dimethyloxaloylglycine (DMOG) can inhibit hypoxia inducible factor-1alpha (HIF-1α) subject to degradation under normal oxygen condition in cells. Objectives: The objective of this study is to detect the effects of DMOG on the proliferation and differentiation of spermatogonial stem cells (SSCs) in Bama minipigs. Methods: Gradient concentrations of DMOG were added into the culture medium, HIF-1αprotein in SSCs was detected by western blot analysis, the relative transcription levels of the SSC-specific genes were analyzed using quantitative reverse transcription polymerase chain reaction (qRT-PCR). Six days post-induction, the genes related to spermatogenesis were detected by qRT-PCR, and the DNA content was determined by flow cytometry. Results: Results revealed that the levels of HIF-1α protein increased in SSCs with the DMOG treatment in a dose-dependent manner. The relative transcription levels of SSCspecific genes were significantly upregulated (p < 0.05) by activating HIF-1α expression. The induction results showed that DMOG significantly increased (p < 0.05) the spermatogenesis capability of SSCs, and the populations of haploid cells significantly increased (p < 0.05) in DMOG-treated SSCs when compared to those in DMOG-untreated SSCs. Conclusion We demonstrate that DMOG can promote the spermatogenesis activity of SSCs.

OBJECTIVETo investigate the impact of the weekday of surgery on the prognosis of patients with colorectal cancer.

METHODSA retrospective analysis was conducted in patients with colorectal cancer who underwent radical resection in Fudan University Shanghai Cancer Center(FUSCC) between January 2007 and December 2013, and 4 971 patients were identified eligible. Statistical analyses were carried out between patients who received surgery on Monday to Thursday and those who received surgery on Friday. Chi-square test was used to analyze the relationship between clinicopathological parameters and day of surgery. T test was used to compare continuous variables between groups. The 5-year overall survival (OS) and disease-free survival (DFS) were calculated by the Kaplan-Meier method, and compared by log-rank test.

RESULTSThere were no statistically significant differences between two groups in age, gender and pathological grade et al (all P>0.05). However, the number of dissected lymph node was higher in patients who received surgery on Monday to Thursday (median 16) compared with patients who received surgery on Friday (median 14), with statistically significant difference (P=0.038). The 5-year OS and DFS in all eligible patients were 78.0% and 55.0%, respectively. 5-year OS of patients in Monday to Thursday surgery group and Friday surgery group was 79.6% and 77.2%, while 5-year DFS in two groups was 57.8% and 50.4%. There were no significant differences in OS and DFS between two group, with P=0.882 and P=0.210, respectively. Subgroup analyses were conducted according to different pathological stages. 5-year OS of patients at stage I( in Monday to Thursday surgery group and Friday surgery group was 94.7% and 90.6% (P=0.742) and 5-year DFS was 85.1% and 78.2% (P=0.765). 5-year OS of patients at stage II( in two groups was 85.5% and 83.7% (P=0.496) and 5-year DFS was 72.7% and 62.8% (P=0.121). 5-year OS of patients at stage III( in two groups was 69.7% and 69.4%(P=0.354) and 5-year DFS was 41.8% and 37.4% (P=0.976). No statistically significant differences manifested in subgroup analyses.

CONCLUSIONPatients with colorectal cancer undergoing surgery on Monday to Thursday have similar long-term prognosis with those on Friday.

Adult ; China ; Colorectal Neoplasms ; surgery ; Disease-Free Survival ; Female ; Humans ; Lymph Node Excision ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Time Factors

Objective To evaluate the influence of telephone follow-up on treatment compliance behavior of patients with coronary heart disease by conducting a Meta-analysis. Methods Data collection, which was relevant RCTs and experimental study about telephone follow-up on treatment compliance behavior of patients with coronary heart disease, were selected from CNKI, VIP, Wan-Fang databases and PubMed from January 2006 to October 2014. The quality of studies was critically appraised, and data were extracted by two reviewers independently. Meta-analysis was performed by the Review Manager 5. 2 software (RevMan 5. 2). Results Totally 11 studies, which involved 2 717 patients ( the intervention group concluded 1 360 patients and the control group concluded 1 357 patients ) , were analyzed. Meta-analysis showed that telephone follow-up could enhance compliance behavior of patients with coronary heart disease, including reasonable diet [ OR =4.43,95%CI(2.60,7. 53),P <0. 000 01], functional exercise [OR =5. 28,95%CI(2. 92,9. 55),P <0. 000 01], medicine taking as doctors′ suggestions [OR=8. 44,95%CI(3. 82,18. 61),P<0. 000 01] and regular reexamination [OR =6. 79,95%CI(3. 20,14. 41),P <0. 000 01]. Conclusions The education conducted in patients with coronary heart disease through telephone follow-up can help to improve treatment compliance at a certain extent. However, because the low quality of methodology for studies and insufficient evidence, the summary should be check by large sampling, multicenter and high quality RCTs.

Objective To explore the effects of home-based exercise rehabilitation on anxiety in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI),and to improve both mental health and heart rehabilitation of the patients.Methods Totals of 108 patients who were diagnosed with CHD in Renmin hospital of Wuhan university and should have received PCI were recruited into the study from December 2013 to December 2015. The participants were randomly divided into two groups:intervention group (n=54) and control group (n=54). Based on the routine nursing care and discharged education,the intervention group also received home-based exercise rehabilitation with regular follow-up and supervision for exercise. The basic information,self-rating anxiety scale (SAS) and exercise situation were documented and assessed before the intervention,as well as three months and six months after the intervention.Results 48 patients in the experimental group and 46 patients in the control group completed the study. Within the group effect:the SAS had a significant difference (P<0.05) but exercise related indicators (i.e. heart rate,SBP,DBP,sports days) showed no difference between the two groups (P>0.05). Within the time effect:both SAS and exercise related indicators demonstrated statistical differences between each time point (P<0.05). The interaction effects between time and group existed in SAS,SBP,DBP,and sports days (P<0.05),except for heart rate (P>0.05). The intervention group patients performed better exercise compliance (i.e. frequency,duration,intensity,self-protection,warm-up and relaxation exercise) after a six-month intervention,compared with the compliance before the intervention (P<0.05).Conclusions Home-based exercise rehabilitation can effectively alleviate patients' anxiety,and can also improve patients' cardiovascular function and reduce their blood pressure. The regular telephone follow-up and health education can better improve patients' adherence to the home-based exercise rehabilitation.

The incidence of prostate cancer has shown an obvious upward trend in recent years.18F-fluorodeoxyglucose(FDG)is a broad-spectrum imaging agent for cancer,but there is a " blind zone" in the application of prostate cancer.Therefore,exploring prostate imaging agents with better performance can help to make up the deficiency.At present,there are a number of positron imaging agents for prostate cancer,but the overall advantage is not obvious.Recently,a new imaging agent,68Ga-prostate specific membrane antigen(PSMA),has been demonstrated its better value in clinical application of prostate cancer.This review summarizes the research progress of 68 Ga-PSMA,