1.Carnitine in treatment of acute cerebral infarction
Xiu LIN ; Rong YE ; Yaoxin WANG
Chinese Journal of New Drugs and Clinical Remedies 2001;20(2):121-122
AIM: To study the efficacy and adverse reactions of carnitine on patients with acute cerebral infarction. METHODS: One hundred and thirty-five patients with acute cerebral infarction diagnosed by CT or MRI were randomly divided into 2 groups, on the basis of conventional therapy. Sixty-eight patients in carnitine group (M37,F31; age 60 a± s 17 a) received carnitine 2-3g, iv, drip, qd for 28 d. The other 67 patients of control group (M39, F28; age 63 a±17 a) received compound salvia miltirrhiza 20 mL in dextran-40 glucose injection 500 mL, iv, drip, qd for 28 d. RESULTS: The total effective rates of carnitine group and control group for acute cerebral infarction were 80% and 55%, respectively (P<0.05). No adverse reactions were found. CONCLUSION: Carnitine is safe and effective in the treatment of acute cerebral infarction.
2.Significance of detection of EBV-encoded mRNA on bone marrow biopsy tissues of hemophagocytic syndrome
Yaoxin HE ; Xir HUANG ; Chunju ZHOU ; Lin SUN ; Min LI ; Xuemin XUE ; Li ZHOU ; Zifen GAO
Journal of Leukemia & Lymphoma 2011;20(9):532-534
ObjectiveTo investigate the diagnostic significance of different pathology techniques (Immunohistochemistry and ISH)to detect EBV on bone marrow biopsy tissues of hemophagocytic syndrome. Methods Histological,immunohistochemicalandinsituhybridizationwereusedtostudythe hemophagocytic features and expression of LMP-1,EBER and other markers.Results25 out of 51 cases (49.0 %)showed an active proliferation growth pattern while other 12 cases(23.5 %)demonstrated a deterioration morphological character compared with their same age group. The left 14 cases (27.5 %) showed a normal myeloproliferative pattern. 91.4 % (32/35) expressed CD68/KP-1 and 89.5 % (17/19) cases expressed CD68/PG-M1, which showed an abnormal increase of monocytes. 26 out of 51 cases (51.0 %) were positive for EBER,while EBER and immunohistochemistry on LMP-1 were detected simultaneously in 41 cases.The EBER were positive in 19 cases(46.3 %)but none for LMP-1(P =0.000).ConclusionHypoplasia or hemophagocytic features could be detected on bone marrow biopsy tissues of hemophagocytic syndrome, which might be slightly difficult to diagnose. So immunohistochemistry would be essential. Meanwhile, the detection of EBER is more helpful than LMP-1 for diagnosis.
3. The comparison of liver inflammation and fibrosis between chronic HBV and HCV infection
Lin WANG ; Yaoxin FAN ; Yang DING ; Qiuju SHENG ; Chong ZHANG ; Lianrong ZHAO ; Tingting XIA ; Ziying AN ; Han BAI ; Haiyuan SHI ; Xiaoguang DOU
Chinese Journal of Hepatology 2017;25(6):419-423
Objective:
To explore the difference of liver inflammation and fibrosis in patients with chronic hepatitis B virus (HBV) infection and chronic hepatitis C virus (HCV) infection, and to investigate the relationship between hepatic pathology and alanine aminotransferase (ALT).
Methods:
57 patients with chronic HCV infection and 346 patients with chronic HBV infection who were hospitalized at Shengjing Hospital of China Medical University from January 2012 to September 2016 were enrolled. In chronic HBV infection, including 88 cases whose ALT were more than two times of upper limited of normal (ALT≥2×ULN) and 258 cases whose ALT were less than two times of upper limited of normal (ALT < 2×ULN).All the patients were underwent liver biopsy. Chronic HBV infection (ALT≥2×ULN and ALT < 2×ULN) and chronic HCV infection were compared respectively. Statistical analyses were performed using a Univariate
4.Effects of anterior temporal lobectomy on the MMSE score, memory of patients with intractable temporal lobe epilepsy
Xuguang ZHONG ; Guofu WANG ; Yaoxin LIN ; Longshan XIE ; Qixuan SU ; Xiaobing HOU ; Hong YE
Journal of Chinese Physician 2020;22(8):1212-1215
Objective:To explore the effects of anterior temporal lobectomy on the mini-mental state examination (MMSE) score, memory of patients with intractable temporal lobe epilepsy.Methods:104 patients with refractory temporal lobe epilepsy admitted to our hospital from June 2013 to June 2019 were selected, of which 68 cases were treated surgically as the observation group and 36 cases were treated medically as the control group. MMSE score, memory and social functions were compared between the two groups.Results:The total effective rate of the observation group was 95.59%, which was significantly higher than 83.33% of the control group ( P<0.05). The MMSE score of the observation group was significantly higher than that of the control group at 1 month and 6 months after treatment ( P<0.05); the MMSE score of the control group at 6 months after treatment was significantly higher than that before treatment ( P<0.05). Six months after treatment, performance intelligence quotient (PIQ), verbal intelligence quotient (VIQ) and full intelligence quotient (FIQ) in the observation group were significantly higher than those in the control group ( P<0.05), and there was significant difference between the two groups ( P<0.05). The memory quotient (MQ) of observation group was lower than that of control group 1 month after treatment ( P<0.05), and higher than that of control group six months after treatment ( P<0.05). Six months after treatment, the scores of social function and comprehensive quality of life in the observation group were significantly higher than those in the control group ( P<0.05), and there were significant differences between the two groups ( P<0.05). There were 4 cases of complications in the observation group after treatment, all of them improved after drug treatment, without other serious complications. Conclusions:Anterior temporal lobectomy is effective in the treatment of refractory temporal lobe epilepsy, it can improve cognitive and memory functions and social behavior function of patients, and has less complications after operation, with certain clinical application value.