The construction of a vertical ethical review committee for the Center for Disease Control （CDC） in Shanghai will be an important exploration of public health ethics in the field of disease prevention and control， which will provide a practical field for strengthening the public health ethics norms and management of the disease control system and enhancing the awareness of public health ethics of practitioners， as well as plays a positive role in promoting modern public health governance in CDC. The paper demonstrated the importance of construction from three aspects， including the concept， disciplinary scope， and governance practice of public health， namely， the vertical ethics review committee is a tangible means and tool for public health governance to follow the constraints and norms of public health ethics， and is a constraining carrier and concentrated embodiment of the value of population health orientation of the practicing public health ethics. Subsequently， it clarified the feasibility of the social environment of the close relationship between the CDC providing the construction of vertical ethics review committees， as well as the feasibility of the homogeneity characteristics of practice and scientific research in the CDC promoting the work scenarios and fields. Furthermore， from the perspective of management， the construction principles such as system principles， humanistic principles， responsibility principles， and efficiency principles were substantiated. The construction framework was proposed in terms of construction objectives， subjects， objects， and norms， to provide an innovative practice for the conception of the construction of regional public health ethics committees.