Objective To explore the application effect of high quality nursing service in outpatient nursing work, to improve the quality of nursing work. Methods This study selected clinic patients as the research object of high quality nursing before and after 1 month, since June 2014 to carry out high quality nursing activities so far, activitied into the stable period,from September 2014 outpatient treatment of 50 cases as the observation group,high quality nursing January 2014 outpatient treatment of 50 cases as the control group,SAS score,nursing satisfaction were compared be-fore and after treatment in the patients of two groups of cases of outpatient registration and the waiting time, waiting time of auxiliary examination were compared. Results Nursing satisfaction results in the observation group was 98.0%,significantly higher than the control group of 76.0%,the difference was statistically significant between two groups(P<0.05).The observation group cases outpatient registration waiting time less than or equal to 15 min was 92.0%, auxil-iary examination waiting time less than or equal to 15 min was 94.0%,were above 90%,were significantly higher than those in control group,the difference was statistically significant between two groups (P<0.05). Before treatment,SAS score of two groups of patients, there was no significant difference (P>0.05). After treatment, two groups of patients with SAS score decreased significantly(t=8.342,t=7.213,P<0.05),and the SAS score of observation group after treatment was significantly lower than the control group, there were significant differences(P<0.05). Conclusion The development of high quality nursing service in outpatient nursing work is helpful to improve nursing satisfaction, reduce the patient's anxiety,shorten the time of examination,so as to further improve the quality of outpatient nursing work.