The family of bone morphogenetic proteins (BMPs) belongs to the superfamily of transforming growth factor-β (TGF-β). It has various functions in the body. In recent years the BMPs family(especially the BMP7) has been discovered to play an important role on the genesis and development of cancer. In this article the characteristic, the mechanism and the function of BMP7 in the genesis and development of cancer are summarized.

The arterial supply of the human metatarsals in 90 lower limbs,ranging in age from newborn to87 years,was studied by perfusion method. The blood supply of the metatarsals is derived from the nutrient artery,the periosteal arteries,the epiphyseo-metaphyseal arteries and the pseudoepiphyseal arteries. The proximal and distal branches of the nutrient artery supply the inner two-thirds or three-fourths of the cortex. The periosteal arteries give off a few twigs penetrating into the cortex and supplying the outer one-third or one-fourth of the cortex. The radiate form epiphyseo-metaphyseal arteries derived from superficial plexuses in continuity with the periosteal networks on the shafts, supply the base of the first metatarsal, and the heads of the other four. The pseudoepiphyseal arteries, penetrating the non-articular areas of the bones, supply the bases of the second, third, fourth and fifth metatarsals and the head of the first. The sources of the nutrient arteries to the metatarsal vary with the different bone . The nutrient arteries to first metatarsal bone usually originate from the ramus plantaris profundus and the first plantar metatarsal artery, while the nutrient arteries to the other metatarsal bones mainly derive from the plantar metatarsal arteries, the plantar arch and its perforating branches. The clinical significance of the arterial distribution to the metatarsals is discussed.

This paper reviewed the clinical research progress of the treatment of children's adenoid hypertrophy in recent years from the aspects of Chinese medicine treatment and combined traditional Chinese and western medicine treatment. It is believed thatTraditional Chinese medicine treatment for the children with adenoid hypertrophyhas showed better curative effect and less side effects, which can reduce the operation rates. It's easy for parents and children to accept and can be widely promoted in clinical.

Objective The complex morphological variation and sources of Tibetan medicinal plants from Aconitum genus make it difficult to identify the medicinal materials correctly. In addition, the toxicity of these materials could be a huge challenge for the safety of drug use. A rapid and accurate method for the identification and classification of Tibetan medicinal herbs of Aconitum genus was built by using ITS2 sequences as DNA barcodes. Methods A total of 50 samples of Aconitum chasmanthum, A. liangshanicum, A. kongboense, A. gymnandrum, A. pendulum, A. tanguticum, A. phyllostegium, A. campylorrhynchum, A. Polyschistum, and A. sessiliflorum were collected from the Qinghai-Tibet Plateau. PCR amplification and sequencing of ITS2 sequences were conducted after the extraction of DNA. Genetic distance, neighbor joining (NJ) phylogenetic tree and secondary structures of ITS2 sequences were analyzed using MEGA 6.0. Results The maximum distance between species was greater than the minimum distance within each species, NJ tree showed that the samples went to 12 separate branches, differences among the secondary structures of ITS2 sequences also made it clear to identify these species. Conclusion Using ITS2 sequence as DNA barcode can be an accurate and rapid method for identification and recognition for Tibetan medicinal plants of Aconitum genus, which provides a reliable technical means to ensure safety use of these Tibetan medicines.

Objective To study the correlation of the level of high-sensitivity C-reactive protein (Hs-CRP) in the acute phase of ischemic stroke and progressive stroke. Methods 101 patients with acute ischemic stroke were collected. Serum Hs-CRP of all patients were measured at 24 hours after admission , the onset of 48 hours, the onset of 72 hours by latex enhanced immune turbidity method. According to their serum Hs-CRP lev-els, the patients were divided into the group of Hs-CRP sustained growth (n = 35) and the group of non Hs-CRP sustained growth (n = 66). The NIHSS scores were assessed on two groups of patients , Logistic regression analysis was made to screen the related factors of Hs-CRP increase and the possible risky factors for progressive ischemic stroke. Results There was a significant difference of serum Hs-CRP level between the two groups (P <0.001). The incidence of progressive stroke in the group of Hs-CRP sustained growth was significantly higher than that in the group of non Hs-CRP sustained growth (χ2 = 32.710, P < 0.001). Logistic regression analysis showed blood glucose , white blood cell count , triglyceride level and NIHSS scores at admission were associated with sustained growth of Hs-CRP and the factors that they included Hs-CRP sustained growth , admission NIHSS scores, diabetes mellitus and pulmonary infection were regarded as independent risk factors. Conclusion The sustained growth of Hs-CRP in the acute phase of ischemic stroke is an independent predictor of progressive stroke.

Objective To separate and screen components with fibrinolytic enzyme activity from twelve Chinese herbal medicines. Methods The components were extracted with water and precipitated with salt, and they were tested by fibrinolytic protein plates method. The active components with fibrinolytic activity were separated and screened which were compared with urokinase. Results Eleven of the twelve extracts showed fibrinolytic activity, while Trichosanthes kirilowii got the biggest fibrinolytic zone after 36 hours, followed by Alisma plantago-aquatica and Leonurus japonicus, and the Radix Astagali got the smallest one. According to the concentration of the protein, the area of the fibrinolytic zone and the specific activity of the components, the extract from Angelica sinensis exhibited the best specific activity at level of 48.46U/mg. Conclusion The extracts from Chinese herbal medicines except Semen Persicae exhibit fibrinolytic enzyme activity which can dissolve the fibrin in different degrees.

The extended service in domestic and foreign medical libraries was summarized according to the trans-formation of medical library and the need of public health information followed by a description of some typical cases of extended service provided by MedlinePlus website , Disaster Medical Information Management Research Center , and patient libraries in order to provide the reference for domestic medical libraries to cary out their extended service .

After the significance to asses the value of information resources in hospital library was elaborated, the methods to assess the value of information resources in hospital library were constructed by contingent valuation and investment return analysis in combination with the practical service in hospital library according to the analysis of the economic value assessment in domestic and foreign public libraries and academic libraries.

ObjectiveTo investigate the clinical features of patients with painless acute pancreatitis ( AP),and to improve the diagnosis accuracy of painless AP.MethodsThe clinical data of 12 patients with painless AP were retrospectively collected from January 2007 to January 2011.Results The mean age of patients with painless AP was 52 years old.Seven (58.3％) patients complained of abdominal distension and discomfort,4 (33.3％) patients complained of nausea and vomiting,abdominal tenderness occurred in 7(58.3％ ) patients.Serum levels of lipase and amylase was increased in 11 (91.7％) and 8 (66.7％)patients,respectively.The diagnostic accuracy of abdominal ultrasound and CT for AP was 58.3％ and 91.7％,respectively.Five (41.7％) patients were diagnosed to have AP upon admission,and 4 patients were misdiagnosed to have non-digestive diseases.There were 7 severe AP patients among the 12 painless AP patients,and the percentage was significantly higher than that in AP patients with pain (65/327,x2 =7.30,P ＜ 0.05).Painless AP patients needed longer hospital stay when compared with that of AP patients with pain [ ( 20.4 ± 9.1 ) d vs.( 12.9 ± 6.2) d,t =2.296,P ＜ 0.05 ) ].ConclusionsThe misdiagnosis rate of painless AP is high and patients with painless AP are in critical situation,and early measurement of serum levels of lipase and amylase,as well as CT scan is important for correct diagnosis.

OBJECTIVE:To study the legislative evolution and causes of biologics data protection system in the United States, and provide reference for designing biologics data protection system in China. METHODS:Started from analyzing the features of biologics data protection in the United States,through analyzing the legislative struggle of biologics data protection in the United States,the caused and its enlightenment to China were explored. RESULTS & CONCLUSIONS:After legislative discussion evolu-tion and struggle,the United States enacted the Biologics Price Competition and Innovation Act in 2010,established the world's firststrong protectionstandard of biologics data protection system,and determined the 12-year data protection period. The legisla-tive basis was to stimulate the strategic needs of innovation,the direct cause was that a biological analogue simplified application was established in the United States,and the key factors included biologics technical attributes and patent protection features. Cur-rently,biologics data protection system is not suitable for China,and China should implement the system from nothing,from weak to strong when the national condition matches or strategic choice needs. Meanwhile,a mature registration approval system is the ba-sis of establishing data protection system.