1.Application of schema theory in the practice of medical listening teaching
Chinese Journal of Medical Education Research 2006;0(07):-
Medical English listening is an important part of English education in medical institutes. On the basis of schema theory,this paper tries to explore the application of the theory in the teaching practice of medical listening and focuses on how to improve the teaching quality of medical English listening from the perspectives of phonetic schema,vocabulary schema and background schema.
2.Ms. Cheng Zhiqing’s Clinical Experience in Treating Hypertension with Insomnia in Menopause
Journal of Zhejiang Chinese Medical University 2015;(6):448-450
Objective] To sum up Pro. Cheng Zhiqing’s clinical experience in treating hypertension with insomnia in menopause. [Method] Select 3 classical cases of the disease above treated by Pro. Cheng Zhiqing for analysis and discussion, and summarize her differentiation thought and treatment features. [Result] In her view, such disease is mostly concerned with liver, as well as related to heart, kidney, etc., the pathological course concerns mother-organ disorder involving its child-organ, so the therapy shall center on stretching liver, clearing liver, smoothing liver and tonifying liver, also purging child-organ in excess, nourishing mother-organ in deficiency, treating multi-organ in the same time, therefore to get better clinical effect. [Conclusion] For the hypertension with insomnia in menopause, Pro. Cheng Zhiqing is good at grasping disease mechanism, revising famous and recipe decoctions in generations, with close compatibility of medicines, definite cure effect, worth reference.
3.EFFECT OF VITAMIN A ON THE LUNG METASTASIS IN C_(57)BL MOUSE MELANOMA
Chinese Pharmacological Bulletin 1986;0(04):-
Effects of vitamin A on antimetastatic activity of alveolar M 0 were studied. The results were as follows:1 . SD rats recieved vitamin A were killed and their alveolar M0 were harvested by lavage and cocultured with prelabelled B16 Melanoma cells for 48h in proportion of 20 : 1 , the average precentage of cytotoxity were 34.28%;2 . Zymosan-C3b rosette formation in SD rats treated with vitamin A was significantly increased. The average rosette forming rate was 43.00%. It was markdly higher than those of controls ( P
4.Value of clinical manifestations in predication of prognosis of patients with diffuse axonal injury
Chongjie CHENG ; Yao YAO ; Xiaochuan SUN
Chinese Journal of Trauma 2012;28(3):215-219
ObjectiveTo investigate the relationship of clinical manifestations with prognosis of patients with diffuse axonal injury (DAI) and select the indices that can accurately evaluate the prognosis so as to create a predictive model of outcome of DAI patients.MethodsClinical data of 98 DAI patients were retrospectively analyzed to identify the relationship between the indices and outcomes through Cochran-Mantel-Haenszel x2 test or Student-Newman-Keuls one way variance test via SAS 8.1.Then,the indices was analyzed through multivariant cumulative stepwise way so as to establish the Logistic regression model. Results (1)The indices including Glasgow Coma Score (GCS) on admission,combined with other type of cerebral injuries,unstable vital signs,abnormal pupil size and reactivity,decerebrate rigidity,imaging with characteristic DAI signs,paralysis of the limbs and length of coma were correlated with the outcome,while the indices including gender,age,injury mechanism,pathologic signs and decorticate rigidity were insignificantly associated with the outcome.(2) The logistic regression model showed that GCS on admission,paralysis degree of the limbs,abnormal pupil size and reactivity,and combined with cerebral injuries were the optimum predictors of outcome of the DAI patients.ConclusionsThe logistic regression model in the study is a reliable tool in predicting the prognosis of DAI patients.The patients wit higher GCS on admission may have better outcome.The patients with light degree of paralysis,normal pupil size and reaction,and combined with none cerebral injuries may have sound prognosis.
5.The analysis ofβ-lactam antibiotics interference in fructosamine testing
Wei YAN ; Jing ZHOU ; Wenjuan YAO ; Ran CHENG ; Xiaoming YAO
International Journal of Laboratory Medicine 2014;(22):3097-3098,3101
Objective To evaluate the interference of 13 kinds of β‐lactam antibiotics in fructosamine detection .Methods A se‐ries of solution of antimicrobial drugs were formulated with water for injection ,and added into the mixture fresh serum volume by 5% .Interfere with antimicrobial drugs on the test results of fructosamine were evaluated .Results When the blood concentrations of cefathiamidine and ticarcillin sodium/clavulanate potassium were up to 37 .5 mg/L and 247 .5 μg/mL respectively ,they began to produce positive interference on fructosamine detection .However ,the degree of interference was not correlated to the serum concen‐tration of fructosamine .Conclusion Cephathiamidine and ticarcillin sodium/clavulanate potassium have positive interference on fructosamine detection .
6.Relation of the associated biomarkers and the early clinical outcomes in acute cerebral infarction
Jing SUN ; Yuanrong YAO ; Yan CHENG
The Journal of Practical Medicine 2014;(3):393-396
Objective To investigate the relation of the associated biomarkers and the early clinicaloutcomes in acute cerebral infarction. Methods Three hundred and seventeen patients with cerebral infarctionwere enrolled after the first onset. Coagulation function, liver, kidney function, blood cholesterol, andelectrolytical were tested within 24 hours of onset. Chinese Stroke Scale (CSS) and National Institutes of HealthStroke Scale (NHISS) were scored on admission, and NHISS on the tenth day after admission were scored.Evaluated the severity on admission and early functional recovery on the tenth day after admission with CSS andthe difference of NHISS. According to CSS, patients were divided into three groups: mild, moderate and severegroup. According to scale margin of NHISS between on admission and the tenth day after admission , patients weredivided into three groups: improved group, unchanged group and worsened group. Difference of biomarkers amongdifferent groups were statistical analyzed. Results Serum calcium (SC), TBIL, FIB, HCY, SUA levels amongmild, moderate and severe group were significantly different (P < 0.05). The more severe, the higher TBIL,FIB, HCY, SUA levels and the lower SC level. The SC, FIB, SUA levels were significantly different amongimproved group, unchanged group and worsened group (P < 0.05). SC level were the lowest in worsened group,while FIB, SUA levels were the highest. Conclusions In acute cerebral infarction patients, SC, FIB, SUAlevels are closely related to the severity and early clinical prognosis.
8.Effect of Paroxetine on Sleep Apneas in Sprague-Dawley Rats
Yao WANG ; Guangfa WANG ; Cheng ZHANG
Chinese Journal of Respiratory and Critical Care Medicine 2009;8(4):384-387
Objective To evaluate the effects of selective serotonin reuptake inhibitors (SSRIs) on sleep apneas in Sprague-Dawley (SD) rats.Methods Thirty adult male SD rats were randomly divided into two groups (15 rats in each group).The treatment group and the control group were injected intraperitoneally with paroxetine (10 mg · kg-1·d-1) and sterile distilled water (2 mL · kg-1 · d-1) for 7 days respectively.Parameters about sleep apnea and sleep structure were measured before and after the treatment.Results In the treatment group, there was a significant reduction of apnea index (AI) from (12.4±3.7) times/hour to (7.4±2.2) tmes/hour (P = 0.000).Both post sigh apnea index (PSAI) and spontaneous apnea index (SPAI) were decreased significantly (P = 0.000 and 0.021 respectively) in non-rapid eye movement (NREM) sleep, but not in REM sleep.REM sleep was reduced from 8.6% to 8.0% (P = 0.013) and its latency was increased from (54.1±48.4) rain to (110.9±43.4) min (P = 0.001) in the treatment group,as well as the sleep-onset latency [from (20.7±9.1) rain to (30.0±15.7) rain, P = 0.038].Conclusion Paroxetine can reduce sleep apneas in SD rats during NREM sleep.Its effects on sleep structure include reducing REM time,increasing REM latency and sleep-onset latency.
9.Analysis of the risk factors related to early neurological deterioration in patients with recurrent cerebral infarction
Yu ZHANG ; Man CHENG ; Yuanrong YAO
The Journal of Practical Medicine 2016;32(7):1037-1040
Objective To study the risk factors related to early neurological deterioration (END) in patients with recurrent cerebral infarction (RCI). Methods Three hundreds and twenty-six RCI patients admitted to our hospital from January 2014 to March 2015 were divided into END group (n = 66) and non-END group (n =260). The clinical and laboratory data were collected, and their cerebrovascular lesions were accessed according to the angiographic findings. Results (1) Single factor analysis showed the level of cholesterol was significantly higher in the END group than that of the non-END group (P < 0.05). The proportion of patients suffering from smoking, arterial occlusions, early onset stroke associated pneumonia (SAP) and hyponatremia was also higher in the END group (all P < 0.05). (2) Logistic regression analysis showed that arterial occlusions (OR = 2.137, 95%CI 1.093~4.181), SAP (OR=2.001, 95%CI 1.023~3.912) and hyponetremia (OR=2.467, 95%CI 1.217~ 5.000) were independent risk factors for END of RCI patients (all P < 0.05). Conclusion Arterial occlusions, SAP and hyponatremia may be used as predictors of the early development of RCI patients.
10.Roles and mechanism of inflammation in intracranial aneurysm formation and rupture
Pengfei YAO ; Gang CHENG ; Chen GAO
International Journal of Cerebrovascular Diseases 2016;24(3):275-278
Inflammation is involved in the pathogenesis of many vascular disorders. Hemodynamics cause the activation of inflammatory factors in the vascular wal , resulting in dysfunction of vascular endothelial cels and vascular smooth muscle cels, activating vascular wal inflammatory cascade. Inflammatory cels, especialy macrophage infiltration and secretion of enzymes gradualy weaken the vessel wal to form aneurysm, and even cause aneurysm rupture. Therefore, inflammation plays a key role in the formation and rupture of intracranial aneurysms.