OBJECTIVE: According to the holism in traditional Chinese medicine (TCM) theory, this manuscript explores the relativity of pathogenesis among hypertension, diabetes and hyperlipemia.DATA SOURCES: We applied computer to search articles in English on pathogenesis ofhypertension, diabetes and hyperlipemia in Medline between January 1985 and December 2004 by words "hypertension, diabetes, hyperlipemia, pathogenesis" .Besides, we also used computer to search articles in Chinese on pathogenesis of hypertension, diabetes and hyperlipemia in Chinese magazine full text database between January 1990 and December 2004 by words "hypertension, diabetes, hyperlipemia, pathogenesis".STUDY SELECTION: Primarily, articles on pathogenesis of hypertension,diabetes and hyperlipemia were selected in TCM and modern medicine respectively. Accepted standard were: ① Random control clinic test with methods of single blind, double blind or no blind; ② Nonrandom control test;③ Fore-and-aft control test; ④ Chapter in monograph. Eliminated standard:repeated research.DATA EXTRACTION: Totally 28 articles on pathogenesis of hypertension,diabetes and hyperlipemia were found in TCM and modern medicine, however, 12 articles were selected according to accepted standard, and 16 articles were eliminated due to repeated content.DATA SYSTHESIS: Totally 12 selected articles were analyzed on pathogeneses of hypertension, diabetes and hyperlipemia in TCM and modern medicine, and hinted internal affiliation of these three diseases from view of molecular biology.CONCLUSION: These three diseases can be regarded as a whole entity for study. High blood pressure, high blood sugar and high lipemia could be treated as different forms of the entity or in different developing courses of the whole. In a certain course it might present as one of the forms specifically. It might manifest high blood pressure mainly in clinic, or high blood sugar, or high lipemia,also several forms at the same time. It will be beneficial to take the holism and visceral theory in TCM for reference in research of modern medicine.

Objective To study the influence of Orem self-care theory on postpartum quality of life and role change of parturients with natural labor. Methods 100 parturients with natural labor in our hospital from May 2010 to July 2011 were selected as research object,and they were randomly divided into the control group and the observation group with 50 cases in each group,the control group was taken care with routine nursing methods,the observation group was given with nursing according to Orem self-care theory.Then the SCL-90 score,situation of role change and satisfaction degree of two groups before nursing and on the second and fifth days after nursing were analyzed and compared. Results The SCL-90 score of the observation group after the nursing on second and fifth days was all lower than those of the control group,the better rate of role change was higher than that of the control group,patients'satisfaction degree was higher than that of the control group. Conclusions The Orem self-care theory plays an important role in improving the quality of life and role change of parturients with natural labor after delivery,and it can significantly improve satisfaction degree of parturients.

Intrauterine growth retardation (IUGR) can improve the danger of insulin resistance syndrome. It was reported that regulatory factors of βcells development and enzymes of regulating metabolism of glucose, fat, insulin signal transduction and effecter molecule were expressed at a low level in the IUGR. As a result, the number of β cells, proliferation, insulin secretion and insulin sensitivity was reduced, apoptosis was increased, and glucose intake in peripheral tissue declined. All these factors contribute to the insulin resistance syndrome.

OBJECTIVE:To establish an HPLC method for determination of major component and related peptide in eptifibatide injection.METHODS:The determination was performed on AichromBond-AQ C18 column with column temperature at 25 ℃ and flow rate of 1.0 mL?min-1.The mobile phase consisted of acetonitrile-water(0.13% trifluoroacetic acid).The detection wavelength was set at 220 nm and injection volume was 20 ?L.RESULTS:The linear range was 75.2～1 203.6 ?g?mL-1(r=0.9999) with mean recovery of 99.73%～99.95% (RSD=0.26%).CONCLUSION:The method is simple and rapid and it is applicable for determination of major component and related peptide in eptifibatide injection.

Flow Cytometry ; instrumentation ; Indicators and Reagents ; Investigational New Drug Application

According to the traditional Chinese medicine (TCM), atopic dermatitis (AD) is believed that it is caused by innate constitutional insufficiency and dysfuction of heart and spleen. Thus, the treatment includes strengthening the spleen and clearing dampness, nourishing blood and moisturing skin. This paper reviewed literature about the researches on AD, and summarized the etiology and pathogenesis of the disease in order to investigate new treatment.

Community health service in the new century has entered a new stage of development. To ensure the healthy advancement of community health service in the course of system building, the following guiding principles must be adhered to: spurring on system innovation with concept innovation and giving full play to the staying power of community health service; taking the introduction of the competition mechanism as the soul and unremitting impetus of innovation; persisting in the solution of problems accompanying advance and development with methods promoting development; taking the strategic readjustment of health resources as the main line of development; taking the attainment of a favorable external environment as the impetus of development; and sticking to a path of coordinated growth that stresses both quality and speed.

Splice variants are transcripts that exhibit various functions or activities and are obtained from alternative splicing of precursor mRNA. An increasing number of tumor-specific splice variants are being discovered and their roles in cancer development and progression are being investigated. In this study, the expression patterns and activities of tumor-specific splice variants were charac-terized. The results suggest that a variant-specific gene therapy that targets cancer cells would be more specific and would have minimal effect on healthy tissues. Using antisense oligonucleotides, mRNA that contributed to cancer cell survival and altered splicing patterns was downregulated in a clinical trial. The results provide a new appreciation for the gene therapy of cancer. Identification of novel tu-mor-specific splice variants and constant improvement of therapeutic strategies by modifying splicing patterns can lead to the develop-ment of more effective and safer cancer therapies.

Objective]To expound the essence and method of detoxification in the view of keeping internal balance ,based on Huangdi’s Internal Classic. [Method] From the present social understanding of toxin biased ,and on the basis of collecting and analyzing the materials concerning the record of concept and treatment of eliminating toxin in early medical classic ,eliminating toxin and keeping balance can be taken as a sort of health care idea. [Result] The toxin in body refers to the imbalance of Yin and Yang Qi and blood of human body ,it also may be the cause and new pathological products. This recognition corrects the understanding of contemporary society point ofDetoxification ,and guides people to follow the body's own adjustment mechanism,the function of organs and individual constitution to determine etiologic factors based on differentiation treatment. It will avoid and prevent producing the toxin in accordance withIn order to maintain body balance and adjust yin and yang of body through careful diagnosis said by Huangdi ’s Internal Classic. [Conclusion] That one specific treatment depending on one specific toxin reflects the principles of syndrome differentiation treatment and searching for the primary cause of disease in treatment by exploring Huangdi ’s Internal Classic. And it can make people understand more accurately and profoundly about detoxification and live healthier.

In this paper attempt has been made to observe the effect of Anordrin and its analogue SIPPR-113 on the morphological characters of uterine endometrium in mice implantation period and after castration. 100 mice were used in two experiments. The first experiment was performed in mice after mating, it included 5 groups as follows: control, estradial, progesterone, Anordrin and SIPPR-113 groups. The mice were treated with least doses (2-4mg/kg) which can prevent implantation on dayl-2 after mating. The animals were killed on the 5th day of pregnancy. The second, experiment contained also 5 groups: mature female mice were treated with 1/4-1/2 of above doses on the 25-26th day and were killed on the 29th day after castration. The uterine endometrium was embedded with paraffin and Epon812, histological sections and semi-thin sections (1ftm thick) and ultra-thin sections were made. They were observed under light microscope and electron microscope (Hitachi-600). Similar results were obtained in the two series of experiments. The endometrium had grown obviously and the numbers of glands and of cell's mitosis were increased, edema was indicated in stroma, as well as secretory function of glands was prevented period of implantation. Some lysosomes and lipid drops were found in the glandular cells and micro-filaments were observed in stromal cells under electron microscope. The effect of SIPPR-113 were similar to Anordrin, their anti-implantation action may be related to their estrogen and anti-progestrone action. Acknowledgement: This work was supported by WHO Special Programme in Human Reproduction.