Wheezing in children is a common problem.Approximately 30 percent of infants will have at least one wheezing episode.Although asthma is the condition most commonly associated with wheezing,the high prevalence of wheezing as a common presenting complaint requires consideration of a broad and age-dependent differential diseases.A high index of suspicion of cardiovascular anatomic anomalies should be maintained in infants and children with recurrent wheezing and minimal improvement despite reasonable treatment.Compression of the pediatric airway is a relatively common and often unrecognized complication of a variety of cardiovascular diseases.The most common congenital anomalies associated with airway compression are the vascular rings.Vascular ring abnormalities are aortic arches abnormalities,aberrant left pulmonary artery (pulmonary sling) or aberrant i nnominate artery (innominate artery syndrome).Aortic arches abnormalities include double aortic arch,right/left sided aortic arch with ligamentum arteriosum and aberrant left subclavian artery or cervical aortic arch.Other rare reasons could cause the compression of airway are absent pulmonary valve,aneurysm,left atrial enlargement or massive cardiomegaly.Imaging techniques are usually required for diagnosis.First-tier evaluation of the child with recurrent wheeze should include a chest radiograph.Echocardiography,multi detector computed tomography (MDCT) or magnetic resonance imaging (MRI) are performed as the diagnostic pathway.Bronchoscopy is currently the techniques to assess the degree of bronchial malacia and narrowing in pre-operation.Treatment of these abnormalities usually is surgical.

BACKGROUND: Anchorage control is a critical part of orthodontic treatment, and physiologic anchorage loss consists of molar growth and drifting.OBJECTIVE: To detail the principles of physiologic anchorage spee-wire system through the growth and biologic force aspects.METHODS: A computer retrieval of PubMed and CNKI databeses was performed for relevant articles published from June 1976 to October 2016 using the keyword of physiologic anchorage control;anchorage loss; mandible growth in English and Chinese, respectively.RESULTS AND CONCLUSION: The physiologic anchorage spee-wire system cannot only avoid natural growth-induced physiological anchorage loss but also preserve molar anchorage,so as to achieve the request of maximum anchorage.

Tracking changes in the number and function of T cells is of great value to clinical diagnosis and evaluation of the efficacy of allergen immunotherapy. This review summarizes research progress in detection methods for allergen-specific T cells and their application, such as carboxyfluorescein succinimidyl ester dilution assay, enzyme-linked immunospot assay, intracellular cytokine staining assay and microarray immunosensors, providing references for selecting and developing appropriate detection methods in clinical practice.

Objective To discuss the influence of high-quality rehabilitation model intervention on postoperative anxiety,depression and quality of life in patients with colorectal cancer.Methods 60 patients with colorectal cancer in our hospital were randomly divided into the observation group and the control group,30 cases in each group.The control group was given routine nursing measures.The observation group received high-quality rehabilitation model intervention on the basis of routine nursing measures.SAS and SDS were used to observe the psychological status of the patients,SF-36 was used to observe the quality of life of patients.Results Two weeks after operation,SAS,SDS scores of the observation group were (47.5 ± 5.2) points,(49.7 ± 5.7) points,which were significantly lower than (55.2 ± 6.3) points,(53.4 ± 5.8) points of the control group (t =5.163,2.492,all P ＜ 0.01).Two weeks after operation,the general health,physiological function,physical function,body pain,activity,social function,emotional function,mental health,quality of life score in the observation group were (79.06 ± 3.78)points,(79.57 ±3.96)points,(78.39 ± 3.71) points,(76.98 ± 3.52) points,(77.59 ± 4.16) points,(75.52 ± 4.85) points,(79.28 ±4.91) points,(78.31 ± 4.27) points,which were significantly higher than those of the control group (74.19 ±4.07)points,(75.24 ± 4.12) points,(71.92 ± 4.38) points,(73.25 ± 3.47) points,(74.06 ±4.13)points,(72.17 ±4.21) points,(74.65 ± 4.35) points,(73.87 ± 3.92) points(t =4.802,4.150,6.174,4.133,3.298,2.857,3.866,all P ＜ 0.01).Conclusion High-quality rehabilitation model can significantly improve the postoperative anxiety and depression,and improve the quality of life of patients with colorectal cancer.

Muscle contusion and articular ligament injury are common among athletes andhave often been treated with a cold compress of Chloro-ethane, which is combustibleand even explodable. For safety's sake we have, after repeated physical and chemical tests and expe-riments on animals, worked out a new freeze-analgesic aerosol, using Freon (F_12) assubstratum and some aromatic ingredients as additives according to both Western andChinese pharmacology. It has been applied some 500 times and a comprehensivestudy made on 118 cases whose records are comparatively intact. The subjects include 81 males and 37 females and among them are 39 footbal-lers, 24 volleyballers, 13 basketballers, 18 gymnasts, 12 track and field athletes, 6fencers, 5 wrestlers and 1 weightlifter. 105 cases, or 90%, are acute soft tissue inju-ries while the rest are chronic injuries causing pain in physical exertion. The effectiverate is 100% with muscular fascia injury and 92% with tendon and articular capsuleinjury. The new aerosol is also markedly effective in treating periostitis of tibia andRotator cuff injuries and in giving first aid to soft tissue injuries for an early re-covery of the lesion. It may be used in all temperatures and produces a satisfactoryhemostatic effect.

OBJECTIVETo evaluate the clinical efficacy of warming-needle moxibustion on cervical headache.

METHODSSixty-one patients of cervical headache were randomly divided into a warming-needle moxibustion group (30 cases) and an acupuncture group (31 cases). Tianzhu (BL 10), Fengchi (GB 20), Wangu (GB 12), Tianyou (TE 16), Hegu (LI 4), Taichong (LR 3) and Zulinqi (GB 41) were selected in the two groups. Patients in the acupuncture group were treated with acupuncture; patients in the warming-needle moxibustion group were treated with warming-needle moxibustion at Tianzhu (BL 10), Fengchi (GB 20) and Wangu (GB 12) and acupuncture at the remaining acupoints. The treatment was given once every other day, 3 times a week, and totally 4-week treatment was given. The duration and frequency of headache, numerical rating scale (NRS) of headache and cervical range of motion (ROM) were compared before and after treatment in the two groups; also the efficacy of the two groups was evaluated.

RESULTSAfter treatment, the duration and frequency of headache, headache NRS.and cervical ROM score were improved in both groups (all P < 0.05), which were more significant in the warming-needle moxibustion group (all P < 0.05). The total effective rate was 84.3% (25/30) in the warming-needle moxibustion group, which was significantly superior to 61.3% (19/31) in the acupuncture group (P < 0.05).

CONCLUSIONThe warming-needle moxibustion presents significant efficacy on cervical headache, which can obviously improve headache symptoms and cervical ROM.

Acupuncture Points ; Adult ; Cervical Vertebrae ; physiopathology ; Female ; Headache ; etiology ; physiopathology ; therapy ; Humans ; Male ; Middle Aged ; Moxibustion ; Neck Pain ; complications ; physiopathology ; therapy ; Range of Motion, Articular ; Treatment Outcome ; Young Adult

anthracycline-induced cardiotoxicity in patients with lymphoma.Methods Thirty-two adult patients with nonHodgkin' s lymphoma who received chemotherapy including anthracyclin were studied.After anthracyclin reached the cumulative doses of 200 and 400 mg/m-2,the changes in plasma BNP and echocardiography indices were investigated.Results After the cumulative anthracyclin reached doses of 200 and 400 mg/m2,serum BNP were respectively (292±7) ng/ml and (387±4) ng/ml,and were significantly increased when compared to the untreated (134±6) ng/ml (P ＜ 0.05).The parameter of diastolic functions ratio of peak early to peak late low velocity (E/A ratio)were 1.14±0.37 and 0.90±0.06,both showing significant decreases compared to the control (1.33±0.27) (P ＜ 0.05).In contrast,systolic function parameters left ventricular ejection fraction (EF) and fractional shortening (FS) remained unchanged (P ＞ 0.05).After the cumulative anthracyclin reached 200 and 400 mg/m2,significant negative correlations were observed between the plasma BNP and the E/A ratio (r =-0.689,P=0.042; r=-0.557,P =0.006),but no associations between EF and FS were found (P ＞ 0.05).Conclusion Plasma BNP concentration appears to be a sensitive parameter for the early assessment of anthracycline-induced cardiotoxicity.

Objective: To explore health resource allocation and optimization and evaluate the clinical departments efficiency in hospital. Methods: Taking a three level of first-class hospital in Beijing for example, the method of data envelopment analysis (DEA) was used for building a DEA model of clinical departments efficiency in hospital. Results: Based on the results of the DEA model, we drawn the technical efficiency and scale efficiency of the target clinical departments, obtained input redundancy rates and output deficiency rates of the non-effective decision-making units. Conclusion:By DEA evaluation results, the input redundancy and output deficiency of the target clinical departments are found. From the perspective of optimizing hospital resource allocation, measures to improve the hospital operational performance are proposed. There is important significance to improve the comprehensive competitiveness of the hospital.

Objective To evaluate the clinical effect of levofloxacin combined with Jingangteng particle in the treatment of patients with chronic pelvic inflammatory disease.Methods According to the random number table, sixty -four patients with chronic pelvic inflammatory disease were divided into control group(n =32)which were treated with levofloxacin and treatment group(n =32)which were treated with levofloxacin and Jingangteng particle for three weeks.The clinical effect,symptoms and signs were evaluated and the adverse reactions between the two groups were observed as well as serum C reactive protein(CRP)were measured before and after treatment.Results The score of symptoms and signs of the treatment group were significantly lower than the control group,the difference was statistically significant [(2.61 ±2.09 )points vs.(5.32 ±3.28)points,t =3.941,P =0.000;(1.47 ± 1.02)points vs.(2.56 ±2.04)points,t =2.703,P =0.008].The level of serum CRP of the control group was (5.46 ± 1.93)mg/L,which was statistically higher than (3.76 ±1.06)mg/L of the treatment group after treatment,the differ-ence was statistically significant (t =4.367,P =0.000).The total effective rate of the treatment group was 96.9%, which of the control group was 78.1%,the difference between the two groups were statistically significant(χ2 =5.142,P =0.023).There was no significant adverse reactions during the treatment.Conclusion Levofloxacin com-bined with Jingangteng particle can obviously improve the symptoms and signs of chronic pelvic inflammatory disease, they have good safety and are worthy of clinical popularization and application.

Objective To compare the ratios of neuron and glia differentiated from the embryonic human neural stem cells(hNSCs) at different times in vitro. Methods The cells from hippocampus of aborted human embryo tissue(8-12 weeks after conception) were mechanically dissociated and cultured with DMEM/F 12 medium containing h-EGF,h-bFGF,h-LIF.The NSCs were induced to differentiate by 1%FBS and identified by Musashil,?-Ⅲ Tubulin,GFAP and Galc immuno-cytochemical staining at different times. Results The cell spheres were Musashil positive at the 12th hour after differentiation.On the 2nd day after differentiation,a few cells exhibited ?-Ⅲ Tubulin and GFAP immunoreactivities,but no Galc positive cells.The number of ?-Ⅲ Tubulin immuno-positive cells reached the highest on the 7(th) day and the percent was 48.2%.The number of GFAP immuno-positive cells increased from the 2nd to the 23rd day and the positive ratio reached 65.3%.A few Galc immuno-positive cells were detected with time passing.Conclusion 1% FBS may promote human NSCs to differentiate into three cell types of central nervous system,and the ratios of differentiated neuron and glia are significantly different at various times.