Parkinson’s disease (PD) is a degenerative disease of the basal ganglia which caused tremor at rest, muscle rigidity and hypokinesia. The exact cause of PD is not clear so far, but what can be certain is that it has something to do with many factors. Administration of drugs is the major therapy for patients all over the world at present. This article introduces the characteristics of most of the drugs used in PD, as well as the trend of PD’s drug therapy.

Objective To compare the contraceptive efficacy, tolerability and bleeding patterns of Implanon and Norplant Methods One hundred healthy female volunteers received either Implanon (75 cases) or Norplant (25 cases) for 4 years, followed up with complain, bleeding patterns, hemoglobin, blood pressure, weight Record the time of insert and remove Results There were no pregnancies during the study Per 90 day reference period, the average number of bleeding spotting days with Implanon decreased from 33 day in the first period to 21 day in the last year, and Norplant decreased from 31 day to 20 day The average bleeding number of times was 2 25 of Implanon and 2 99 of Norplant per reference period( P

BACKGROUND:BACKGROUND:Present studies have shown that bone cement have less osteoinduction and slow degradation in the body,so the effect of alone application is not satisfactory. Therefore,people have modified them,hoping to research a new materials that can overcome all shortcomings above-mentioned. OBJECTIVE:To investigate the ability of decalcified bone matrix (DBM) and acrylic bone cement (ABC) compound in filling and repairing bone defect,and to determine the best component proportion of the composition. DESIGN,TIME AND SETTING:Randomized controlled animal experiments were performed at the Experimental Animal Center,Chongqing Medical University from May to September 2008. MATERIALS:ABC and DBM were prepared into compound material at various proportions (2:8,3:7,4:6,5:5,6:4). METHODS:The animal models of bilateral femur bone defects and fillers were established in the New Zealand White rabbits. The complex material was implanted on the bone defect; the ABC was used as blank control group. MAIN OUTCOME MEASURES:The complex and alone materials were examined by biomechanics and scan electron microscopes. Gross observation,histopathological and X-ray test were used at 4,8,12 weeks after operation respectively to observe the repaired and filled status of bone defect. RESULTS:DBM composite quality of the scope of 3:7 -6:4,the composite materials that existed in more cracks more than 100 ?m,when the DBM was less than 3:7,the material inside the aperture and the majority of material was similar to ABC,mass ratio greater than 6:4 when the DBM and the ABC could not effectively together solidification. When the mass ratio was increased,which matrix particles of demineralized bone and ABC,the compressive ultimate strength of composite materials was less than pure ABC (P

Coronary Artery Disease ; etiology ; therapy ; Humans ; Mucocutaneous Lymph Node Syndrome ; complications ; therapy

Female ; Humans ; Infant ; Male ; Mucocutaneous Lymph Node Syndrome ; Retrospective Studies

35 g/L) by serum albumin determination. Relationship between prognosis and BMI as well as serum albumin was observed. Results:Morbidity of malnutrition was as high as 31.3 %.Concentration of serum albumin was low in most patients. Postoperative complications occurred mainly in malnutrition and hypoalbuminemia group. Conclusions:BMI and serum albumin are related with patients' prognosis and can be used to estimate risks of operations.

Objective To investigate the changes in Toll-like re ceptor 4 (TLR4) and myeloid differential protein-2 (MD-2) gene expression in t he liver of septic rats, and to elucidate the relationship between the expressio n of TLR4/MD-2 mRNA and TNF? mRNA. Methods Sepsis model was reproduced in rats by intraperitoneal injection of LPS (5mg/kg). 80 Wistar rats were randomly divided into 4 groups: normal control and 1h, 2h, 6h after LPS in jection (20 rats for each group). Rats were sacrificed at different time points, and the expression of TLR4/MD-2 mRNA and TNF-? mRNA in the liver was measure d by RT-PCR. Results The expressions of TLR4/MD-2 mRNA and TN F-? mRNA were up-regulated, peaking 1h after LPS injection, and then declined gradually 2~6h after LPS challenge. The expressions at every time point were hi gher than that in control group (P

Objective: To explore neural correlates for the recognition of facial expression videos using event-related functional magnetic resonance imaging.Methods:Thirteen right-handed healthy Chinese women underwent blood oxygen level dependent (BOLD) fMRI voluntarily while recognizing happy, sad, neutral emotional faces and fixation cross videos.Results:In comparison with fixation cross, recognition of neutral faces activated the left middle frontal gyrus, the bilateral precentral gyrus, the right amygdala, the left parahippocampal gyrus, the right postcentral gyrus and the left thalamus. In comparison of neutral faces recognition, the recognition of happy faces elicited increased activation in the right medial frontal gyrus, the right superior frontal gyrus, the middle frontal gyrus, the right anterior cingulated gyrus, the left subcallosal gyrus, the right superior occipital gyrus, the left middle occipital gyrus and the right superior temporal gyrus; while the recognition of sad faces activated the left medial frontal gyrus, the right middle frontal gyrus, the left inferior temporal gyrus and the left superior temporal gyrus.Conclusion:This study indicates that the recognition of facial expression is mediated by a distributed cortical network, and the medial frontal gyrus may be involved in discriminating different affective information, while the superior temporal gyrus may play an important role in processing the dynamic characters of face.

GDP-mannose-3', 5' -epimerase (GME), which converts GDP-mannose into GDP-L-galactose, is essential for the biosynthesis of L-ascorbic acid in higher plants. The molecular characterization of two GME genes from rice has been reported. Firstly,both cDNAs were isolated from the rice mature leaves using RT-PCR technique. By comparing their sequences with homologues from other plants, it was found that GME genes were highly conserved among plant species, though phylogenetic study showed that all known GMEs could be divided into two distinct groups corresponding to monocots and dicots. Secondly, the genomic organization of rice OsGME genes was investigated, and a similarity of splice patterns was revealed. Finally, the expression patterns of the two cDNAs have been studied in various tissues and under different stress conditions by semiquantitative RT-PCR assay. The results showed that the OsGME1 transcript was up-regulated in response to cold stress, and gibberellin might regulate L-ascorbic acid levels by affecting transcription of both OsGME genes.

ObjectiveTo investigate the feasibility,safety and efficacy of tracheal extubation with directly connected negative pressure suction. Methods86 patients with Ⅰ or Ⅱ degree of ASA,aged 18～65 years old,without history of respiratory disease,difficult airway and ventilation problems were involved in this study.All patients undergoing endotracheal general anesthesia were randomly divided into group A and B with 43 cases in each group.Group A used negative pressure directly connected to external side of the endotracheal tube before extubation.Group B used suction tube putting into the endotracheal tube before extubation.MAP,HR,ECG,SpO2,the condition of cough and expectoration and complicatons after extubation were recorded. ResultsIn group A the MAP,HR slightly increased,SpO2 slightly decreased,ECG showed no significant change,but the differences were not significant.In group B,MAP,HR,SpO2 showed significant difference compared with those before extubation and the corresponding period of group A. ConclusionsThe method that connecting negative pressure suction with endotracheal tube can effectively reduce the cardiovascular response during extubation,It also can avoid hypoxia,reduce the tracheobronchial injury and pulmonary complications.It's a practical good method in tracheal extubation.