Narcolepsy is a common chronic sleep disorder attacking adolescence,characterized by a typical tetrad of excessive daytime sleepiness,cataplexy,sleep paralysis and hypnagonic/hypnopompic hallucinations,affecting both mental and psychological aspects of children.Thus,making an early diagnosis and therapy is of great importance.Clinical diagnosis mainly depends on the multiple sleep latency test across the video electroencephalogram.In this article,we mainly describe the diagnosis and treatment progress of pediatric narcolepsy and clinical value of video-electroencephalogram.

Objective To investigate the relationship between PreS1 antigen and five items of HBV serological markers(HBV M), as well as the clinical significance of combined measurement of PreS1 antigen and HBV M in patients with hepatitis B. Methods Enzyme linked immunosorbent assay (ELISA) was applied to testing serum in 268 patients with hepatitis B. Results The detection rate of PreS1 antigen was 85.88% in HBeAg'positive samples,significantly higher than that in HBeAg nega-tive samples(39.34%), P<0.01. Conclusion PreS1 antigen may effectively reflect the situation of HBV amplification. Combined measurement of PreS1 antigen and HBV serological markers in clinical examination contributes to clinical diagnosis,therapeutic effect monitoring and prognosis evaluation.

Objective To understand the the current situation of the slogans in the schistosomiasis health education from the linguistic aspect.Methods Sixty-two slogans in the schistosomiasis health education were collected,then the rationality and validity of them were analyzed from two aspects :the language form and the semantic content.Results Most of the slogans had the appropriate language form and the rational semantic content,they could propagandize the policy and educate the people very well,but there were still some slogans had the inappropriate language form or have the irrational semantic content and so on.Conclusion In order to make the slogans in the schistosomiasis health education more effective,we should attach importance to the language form and the semantic content of them.

OBJECTIVETo systematically evaluate the effectiveness of integrative medicine (IM) for preventing postoperative recurrence of primary hepatic carcinomas (PHC).

METHODSSuch databases as The Cochrane Library, PubMed, EMbase, China National Knowledge Infrastructure (CNKI), VIP Database, Wan-fang Database were retrieved to collect randomized controlled trials (RCTs) on preventing postoperative recurrence of PHC by IM. The retrieval period started from database establishment to June 2013. Literature screening, data extraction, and quality evaluation were performed by two reviewers strictly according to inclusion criteria. Meta-analysis was conducted using RevMan 5.2 Software.

RESULTSA total of 5 RCTs involving 367 patient cases were included. Results of Meta-analysis showed that the IM group was superior to the Western medicine (WM) group in the 1-, 2-, and 3-year recurrence rates (P < 0.05).

CONCLUSIONIn the prevention of postoperative recurrence of PHC, the effectiveness of IM was more significant, when compared with treatment of Western medicine.

Drugs, Chinese Herbal ; therapeutic use ; Humans ; Integrative Medicine ; Liver Neoplasms ; prevention & control ; Neoplasm Recurrence, Local ; prevention & control ; Postoperative Period ; Randomized Controlled Trials as Topic ; Treatment Outcome

Objective To discuss the clinical features of non-conclusion seizures(NCS)in infants less than 1 -year-old,and the diagnostic and differential diagnostic value of video electroencephalography (VEEG).Methods A total of 30 NCS patients were took the regular electroencephalography at the first 20 minutes before VEEG monitoring which continued 2 to 4 hours in order to compare the differences between the two monitoring methods,then all patients were taken follow-up after one month,two months,and three months.Results Three cases attacks(accounting for 10.0%)were found by regular electroencephalograph-y,while 23 attacks(accounting for 76.7%)were found by VEEG following no epileptic discharge,either.All patients were found to be corporality NCS,having no psychogenic NCS,among which,19 patients(accounting for 63.3%)were non epileptic tonic-closure seizures,including 2 patients always keeping eyes staring at somewhere,2 patients gritted teeth or grinned,1 patient often put head back,1 patient stretched the neck or necking down,2 patients shrug his shoulders,9 patients shook head,and another 2 always put forth his strength, with or without stiffness,limb jitter,or made face red;on the other,7 patients (accounting for 23.3%)were benign myoclonus,another 4(accounting for 13.3%)were benign non epileptic infant spasm,no other types were found.Nobody had any antiepileptic therapies,15 of them have no more attacks in less than one month,7 in two months,1 in three months,and another 7 appeared occasionly under the conditions of great happiness,extreme an-ger or been raged.Conclusion VEEG have irreplaceable diagnostic and differential diagnostic value in infants less than 1 -year-old with NCS,and play an important role in monitoring the development of NCS.

Objective To reveal the research focus of schistosomiasis in China through analyzing highly cited schistosomiasis related papers in journals from 2005 to 2012,so as to provide the information for formulating the plan of selecting topics of the edi-tors. Methods The published articles related to schistosomiasis in CNKI from 2005 to 2012 were collected,the citation frequen-cy of the papers was calculated according to formula,and the highly cited papers were selected according to the citation frequency. Then the information of highly cited papers including the published time,type,author and author affiliation,citation frequency, journal,grant and research item,research status and development tendency were analyzed. Results A total of 3 639 published papers related to schistosomiasis were searched and 343 papers(the citation frequency≥8)were selected as highly cited papers, and Chinese Journal of Schistosomiasis Control shared 45.19%of them. Among these papers,original articles,reviews and special reports occupied 44.90%,12.54%and 6.12%,respectively. The first authors of these papers were mainly from centers for disease control and prevention(CDCs)(17.33%),research institutions(22.67%)and colleges/universities(36.00%). Totally 50.44%of the articles received financial supports from research funds/foundations,and most of them were national or provincial funds. The research hotspots focused on epidemiology and prevention,epidemic situation analysis,vaccine,immunologic diagnosis,pharma-ceutical research,immunity and infection. Conclusions The highly cited papers related to schistosomiasis are mainly from CDCs,institutions and colleges/universities. The research hotspots mainly focus on epidemiology and prevention,vaccine,immu-nology and pharmaceutical study. The related journals can use this information to chose topic and solicit contributions to improve their influence.

Objective To study the cytopathogenic effect of epidemic hemorrhagic fever with renal syndrome virus (HFRSV) on renal tubular cells(RTC). Methods Human fetal renal tubular cells (HFRTC) were cultured in vitro. HFRTC infected or not infected by HFRSV were observed by using trypan-blue stain and transmission electron microscopy(TEM). Viral-mRNA was detected by in situ molecular hybridization. Results (1) HFRSV could directly infected HFRTC: (2)The death rate of HFRTC in the infection group was significantly higher than that in the control grou 1 to 4 weeks after infection; (3) Injuries of cell membrane and cell organs after infection with HFRSV were significantly earlier and more severe as compared to control by means of TEM. Conclusion HFRSV can directly damage renal tubular cells (RTC ), which contributes to the pathogenesis of hemorrhagic fever with renal syndrome (HFRS).

Objective To investigate the feasibility of repairing spinal tracts with peripheral nerve graft combing neurotrophic factors in rats following complete spinal cord transection.Methods One hundred and twenty-one male Wistar Rats were transection at T9 level of spinal cord, and randomly divided into five groups. Group A with spinal cord transection was underwent acidic fibroblast growth factor (aFGF) treatment and peripheral nerve grafts (n=25); Group B: spinal cord transection was underwent aFGF treatment only (n=25); Group C: spinal cord transection was underwent peripheral nerve grafts only (n=25); Group D: spinal cord transaction only (n=25); and Group E: sham control (laminectomy only, n=21). The locomotor behavior of all rats was analyzed by the BBB open field locomotor test over the six months of survival time. Motor evoked potentials (MEP) were used to evaluate axon growth across the damage site. Biotinylated Dextran Amine (BDA) and retrograde tracing with fluorogold were used to evaluate the presence of axons through the damage site after treatment. Results The presence of anterograde BDA labeling of corticospinal tract axons at the graft site and fluorogold retrograde labeling of neuron populations was found in motor cortex and in red nucleus, reticulospinal nuclei, raphe nuclei, and vestibular nuclei in Group A. The average latency and amplitude of MEP were improved significantly in Group C. The mean of BBB scores showed significant improvement in Group A. Statistical analysis indicated that Group A had significant improvement compared to Group BC and D at 6 months post-surgery (P

Objective To explore the Troponin I(cTnI) ,myoglobin(MYO) and creatine kinase isoenzyme(CK‐MB) in early di‐agnosis of acute myocardial infarction(AMI) ,and compare their significance in the diagnosis of AMI .Methods used chemilumines‐cence method in 126 patients with AMI and 82 cases of myocardial infarction group to test cTnI ,MYO and CK‐MB ,the results were compared .Results The cTnI ,MYO ,CK‐MB quality appear time and peak time was different ,in patients with acute myocardial in‐farction(cTnI ,MYO and CK‐MB joint detection sensitivity ,specificity ,negative predictive value ,positive predictive value was higher than single test .Conclusion cTnI ,MYO and CK‐MB joint detection is helpful to early diagnosis of AMI .

Objective To analyze the highly cited malaria papers published in Chinese journals from 2006 to 2013,so as to provide the evidence for formulating the plan of selecting topics to the journal editors. Methods The published articles related to malaria included in CNKI and Wanfang medical network from 2006 to 2013 were collected,and the highly cited papers were selected according to the citation frequency calculated by Price’s formula. Then the characteristics of the highly cited papers were analyzed. Result From 2006 to 2013,a total of 1 976 published papers related to malaria were searched in Chinese jour?nals and 98 papers of them were selected as highly cited papers. In the highly cited papers,18 papers were published in China Tropical Medicine,and 16 and 15 papers were published in Chinese Journal of Parasitology and Parasitic Diseases and Chi?nese Journal of Schistosomiasis Control,respectively;and original articles accounted for 42.86%;the first authors of these pa?pers were from 44 institutions,and 40.91%of them were from centers for disease control and prevention(CDCs);a percentage of 22.45%of the highly cited papers received fund programs,and most of them were national or provincial funds. The research hotspots were focused on the epidemiology and control,and epidemic situation of malaria. Conclusion The highly cited papers related to malaria are mainly from CDCs and research institutions,and the related journals could use this information to chose topics and solicit contributions to improve their influence.