1.The relationship between aggression and thyroid hormone and cortisol in schizophrenic patients
Kunxi XUE ; Jing WAN ; Yanzhen REN ; Baoguo DU
Chinese Journal of Behavioral Medicine and Brain Science 2017;26(2):143-148
Objective To explore the relationship between aggressive behavior with thyroid hormone or cortisol and in schizophrenic patients. Methods According to the past violence history and modified overt aggression scale( MOAS) weighted total scores,108 schizophrenic patients were divided into aggressive group ( n=69) and non-aggressive group( n=39) . Positive and Negative Syndrome Scale ( PANSS) total scores, serum thyroid hormone levels and cortisol concentration were compared between the two groups before and af-ter 2,4 weeks treatment. And correlations of PANSS and sub-scales scores,thyroid hormone levels and corti-sol concentration with MOAS weighted total scores and subscales scores were analyzed before these patients receiving treatment. Results Before treatment,total scores of PANSS,positive symptoms and general psy-chopathology scores in aggressive group((94.19±12.71),(23.77±4.94),(52.61±6.45))were higher than that in non-aggressive group ((83.26±11.21),(21.36±7.10),(45.49±6.84)) and these differences were significant(P<0.05). But the difference of PANSS total scores after 2,4 weeks treatment between the two groups was not significant (P>0. 05 ) . Free thyroxine ( FT4 ) level of aggressive group ( ( 14. 41 ± 3. 58 ) pmol/L) was higher than that of non-aggressive group ((12.95±2.66)pmol/L) before treatment and the difference was significant(P<0.05) . Meanwhile,there was no significant differences between the two groups in thyrotropic-stimulating hormone(TSH),free triiodothyronine(FT3),total triiodothyronine(TT3) and total thyroxine( TT4) levels( all P>0.05) . After 2 or 4 weeks treatment,the differences between the two groups in TSH,FT3,FT4,TT3,TT4 levels were not significant(P>0.05). The differences between the two groups of cortisol concentration were not significant before and after 2,4 weeks treatment(P>0.05) . MOAS weighted to-tal scores were positively correlated with PANSS total scores,negative symptoms scores,general psychopathol-ogy scores and level of FT4,and their r values were 0.471,0.204,0.531,0.239(all P<0.05). Verbal aggres-sion was positively correlated with PANSS total scores,positive symptoms scores and general psychopathology scores,and their r values were 0.213,0.215,0.292(P<0.05). Auto-aggression was positively correlated with PANSS total scores and general psychopathology scores,and their r values were 0.278,0.382(P<0.05) . Psy-chical aggression was positively correlated with PANSS total scores,negative symptoms scores,general psy-chopathology scores and level of FT4,and their r values were 0.361,0.193,0.338,0.276(P<0.05). Conclusion The total scores of PANSS,positive symptoms,general psychopathology scores,level of FT4 and their variances can reflect severity of aggression and predict aggressive behavior in schizophrenic patients. Concen-tration of cortisol is not associated with aggressive behavior and can not be used as a predictor of aggressive behavior in schizophrenic patients.
2.Surgical treatment of gastric cancer in the elderly
Jun CHEN ; Zhenggang ZHU ; Min YAN ; Jianyuan XUE ; Haoran YIN ; Yanzhen LIN
International Journal of Surgery 2010;37(6):382-385
Objective To explore the clinical characteristics and surgical treatment of gastric cancer in elderly patients.Methods The clinical data of 431 patients older than 70 years with gastric cancer from 1984 to 1998 were analyzed retrospectively.Results The main clinical manifestations were upper abdominal pain,distension or upset,loss of appetite and weight.The patients with clinicalⅢ,Ⅳ stage accounted for 64.2 percent.Pathological findings showed no specificity.Radical gastrectomy was performed in 215 cases(49.9%),and palliative resection was done in 122 ones(28.3%).The operative mortality and postoperative complication rate were 5.1%and 25.5%in the patients respectively.The 5-year survival rate was 29.5%in the patients with surgery,53.2%with radical gastrectomy and 10.7%with palliative resection.There were significant differences in 5-year survival rate between the radical and palliative groups.Conclusions The majority of elderly patients are clinical Ⅲ,Ⅳ stages and their operative complication rate is high.The key to increase the survival rate and life quality of elderly patients with gastric cancer is early diagnoses,strong perioperative management and suitable radical surgery.
3.Agreement of central vault measurements between UBM and anterior segment OCT in posterior chamber intraocular lens implanted eyes
Chinese Journal of Experimental Ophthalmology 2019;37(4):287-291
Objective To compare the agreement of central vault measurements between anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM) in the eyes with posterior chamber phakic intraocular lens implantation and analyze the association sculus to sculus (STS) diameter and white-to-white (WTW) diameter of cornea with central vault.Methods A cross-sectional study was carried out.Medical records of 150 phakic eyes of 75 myopic patients who underwent implantable collamer lens (ICL) surgery for the correction of myopia were collected in Chongqing Aier Eye Hospital from December 2017 to March 2018.The postoperative central vault were measured with AS-OCT and UBM.Intraclass correlation coefficient (ICC) and Bland-Altman plot were used to evaluate the repeatability and agreement of the measurements between two devices.The affecting factors of central vault measurements were assessed.Results Mean central vault in the 150 phakic eyes after ICL surgery was (0.73±0.25)mm by AS-OCT and (0.76-±0.31)mm by UBM,respectively with the ICC of 0.91 for the measurements of AS-OCT and UBM.Bland-Altman analysis showed that the 95% limits of agreement of central vault measurements were-0.38-0.31 mm between the two devices.Five values were beyond the 95% consistency interval,and the maximum absolute value of the difference was is 0.31 mm,which was beyond the clinical acceptable range,showing an non-interchangeable difference in the central vault measurements between the devices in ICL implanted eyes.WTW was a affecting factor for vault with a regression equation of Y=0.145 3X-0.960 1 (t =2.272,P<0.05).Horizontal and vertical STS were the indirect affecting factors for vault by the association with WTW with the regression equation of Y=0.524 1X+5.362 4 and Y=0.613 4X+4.658 3,respectively.Conclusions Central vault measured by UBM is higher that than AS-OCT after ICL surgery,and the measurements are uninterchangeable between the two devices.Accurate measurement of STS distance is essential for the selection of appropriate lens before operation.
4.Effects of nursing human resources training and performance appraisal information management in a grassroots hospital
Xiujun HE ; Shuangfeng LI ; Yanzhen LU ; Xue SU ; Ying HU
Chinese Journal of Modern Nursing 2018;24(13):1582-1585
Objective To explore the effects of nursing human resources training and performance appraisal information management in a grassroots hospital. Methods From January 2017, Beilun branch hospital, the First Affiliated Hospital of Zhejiang University, carried out self-developed nursing human resources training and performance appraisal information management. We selected 50 nurses before information management (between July to December 2016) and 50 nurses after information management (between January to June 2017) as subjects. And then, we compared the theoretical examination achievements, operation examination achievements, the score of nursing quality and satisfaction with training of nurses before and after implementation. Results After information management the scores of theoretical examination achievements, operation examination achievements, the score of nursing quality of nurses were (93.48±1.95), (94.98±1.87) and (95.43±1.05) respectively higher than those before information management with significant differences (t=17.088, 18.035, 20.392;P<0.01). The satisfaction rate of nurses increased from 64.00% to 96.00% with a significant difference (χ2=16.000,P<0.01). Conclusions The application of information management in nursing human resources training and performance appraisal in a grassroots hospital can improve theoretical and operation examination achievements, increase satisfaction with training of nurses and improve nursing quality. It is worth to be popularized and applied in grassroots hospitals.
5.Relationship between family resilience and mental health among military personnel:a cross lagged analysis
Kaiyuan JING ; Yanzhen YANG ; Shujuan SUN ; Yawen TAN ; Bingqing XUE ; Yijun ZHU ; Mengxue ZHAO
Journal of Army Medical University 2024;46(3):209-214
Objective To explore the causal relationship between family resilience and mental health in military personnel population.Methods A total of 204 military personnel were recruited from an army unit stationed in Western China with cluster convenience sampling.Family Resilience Scale(FRS)and Symptom Checklist 90(SCL-90)were used to survey them twice,in an interval of 4 months.Amos 26.0 was applied to construct a cross-lag model and analyze the data.Results After controlling mental symptoms from the first survey,family resilience in the first measure significantly predicted mental symptoms in the second measure(β=-0.14,P<0.05).After controlling for family resilience from the first survey,mental symptoms in the first measure significantly predicted family resilience in the second measure(β=-0.13,P<0.05).Conclusion The relationship between family resilience and mental health is mutually causal in military personnel,and one predicts the other one.Our findings highlight the key dimensions of the relationship between the two.