Objective To explore the relationship between aggressive behavior with thyroid hormone or cortisol and in schizophrenic patients. Methods According to the past violence history and modified overt aggression scale( MOAS) weighted total scores,108 schizophrenic patients were divided into aggressive group ( n=69) and non-aggressive group( n=39) . Positive and Negative Syndrome Scale ( PANSS) total scores, serum thyroid hormone levels and cortisol concentration were compared between the two groups before and af-ter 2,4 weeks treatment. And correlations of PANSS and sub-scales scores,thyroid hormone levels and corti-sol concentration with MOAS weighted total scores and subscales scores were analyzed before these patients receiving treatment. Results Before treatment,total scores of PANSS,positive symptoms and general psy-chopathology scores in aggressive group((94.19±12.71),(23.77±4.94),(52.61±6.45))were higher than that in non-aggressive group ((83.26±11.21),(21.36±7.10),(45.49±6.84)) and these differences were significant(P<0.05). But the difference of PANSS total scores after 2,4 weeks treatment between the two groups was not significant (P>0. 05 ) . Free thyroxine ( FT4 ) level of aggressive group ( ( 14. 41 ± 3. 58 ) pmol/L) was higher than that of non-aggressive group ((12.95±2.66)pmol/L) before treatment and the difference was significant(P<0.05) . Meanwhile,there was no significant differences between the two groups in thyrotropic-stimulating hormone(TSH),free triiodothyronine(FT3),total triiodothyronine(TT3) and total thyroxine( TT4) levels( all P>0.05) . After 2 or 4 weeks treatment,the differences between the two groups in TSH,FT3,FT4,TT3,TT4 levels were not significant(P>0.05). The differences between the two groups of cortisol concentration were not significant before and after 2,4 weeks treatment(P>0.05) . MOAS weighted to-tal scores were positively correlated with PANSS total scores,negative symptoms scores,general psychopathol-ogy scores and level of FT4,and their r values were 0.471,0.204,0.531,0.239(all P<0.05). Verbal aggres-sion was positively correlated with PANSS total scores,positive symptoms scores and general psychopathology scores,and their r values were 0.213,0.215,0.292(P<0.05). Auto-aggression was positively correlated with PANSS total scores and general psychopathology scores,and their r values were 0.278,0.382(P<0.05) . Psy-chical aggression was positively correlated with PANSS total scores,negative symptoms scores,general psy-chopathology scores and level of FT4,and their r values were 0.361,0.193,0.338,0.276(P<0.05). Conclusion The total scores of PANSS,positive symptoms,general psychopathology scores,level of FT4 and their variances can reflect severity of aggression and predict aggressive behavior in schizophrenic patients. Concen-tration of cortisol is not associated with aggressive behavior and can not be used as a predictor of aggressive behavior in schizophrenic patients.

Objective To explore the correlation between the methylation level of 5-hydroxytryptamine receptor 1A(HTR1A) gene promoter region and severity of symptom in the manic epi-sode patients with bipolar disorder type Ⅰ(BD-Ⅰ). Methods Fifty six manic episode patients with BD-Ⅰand fifty nine healthy controls were randomly included in the study. The level of HTR1A gene promoter meth-ylation was measured with pyrosequencing technique in both manic episode patients with BD-Ⅰ and the healthy controls. The severity of symptoms was assessed with score of Bech-Rafaelsen Mania Rating Scale (BRMS) in patients with BD-Ⅰ. Pearson correlation analysis was employed to explore the correlation be-tween the serum level of HTR1A promoter methylation and score of BRMS in BD-Ⅰgroup. Results In-creased serum level of HTR1A gene promoter methylation was found in manic episode patients with BD-Ⅰ((66. 55±10. 55)%) compared with that in healthy controls((54. 03±8. 85)%)(P<0. 01). Positive corre-lation was found between the serum level of HTR1A gene promoter methylation and total score of BRMS in manic patient with BD-Ⅰ(r=0. 534,P<0. 01). Conclusion The current findings suggest that the serum level of HTR1A gene promoter methylation can be an epigenetic indicator for severity of manic symptom in BD-Ⅰ.

BackgroundDepression is a prevalent emotional problem in adolescents， and parental psychological control is an important predictor of adolescent depression. However， existing research on the acting mechanism between the two is not adequate. ObjectiveTo explore the pathway of negative perfectionism and academic stress between parental psychological control and depressive symptoms among secondary school students， so as to provide references for reducing the incidence risk of depression in such population. MethodsFrom February to April 2023， 1 100 students across 2 middle schools and 2 high schools in Zhongshan city were selected as subjects. The survey was conducted adopting Parental Psychological Control Questionnaire， Chinese Frost Multidimensional Perfectionism Scale （CFMPS）， sense of academic stress subscale in Mental Health Inventory of Middle School Student （MMHI-60） and Center for Epidemiological Studies-Depression Scale （CES-D）. Spearman correlation analysis was adopted to examine the correlation between scores of all scales above， and Amos 24.0 was used to test the mediating path of negative perfectionism and academic stress between parental psychological control and depressive symptoms among secondary school students. ResultsAmong the 1 009 valid questionnaires withdrew （91.73% of the total）， 261 students were detected to have depressive symptoms （25.87%）. As the results of Spearman correlation analysis showed， the scores of the Parental Psychological Control Questionnaire， score of negative perfectionism dimension in CFMPS， score of sense of academic stress subscale in MMHI-60 and CES-D score were positively correlated with each other （r=0.323~0.644， P<0.05 or 0.01）. The direct effect value of parental psychological control on depressive symptoms in secondary school students was 0.128 （95% CI： 0.061~0.201）， accounting for 31.37% of the total effect. Negative perfectionism and academic stress played independently as intermediatory roles between parental psychological control and depressive symptoms in secondary school students， and the indirect effect values were 0.099 （95% CI： 0.068~0.133） and 0.100 （95% CI： 0.060~0.143）， accounting for 24.27% and 24.51% of the total effect， respectively. Negative perfectionism and academic stress acted combinedly as the chain effect pathway between parental psychological control and depressve symptoms in secondary school students， with the indirect effect value of 0.081 （95% CI： 0.060~0.106） accounting for 19.85% of the total effect. ConclusionParental psychological control can affect the depressive symptoms among secondary school students directly， and through independent or chain paths of negative perfectionism and academic stress indirectly. ［Funded by Zhongshan Social Welfare Technology Research Project （number， 2022B1060）］