Objective To investigate the effects of Chaihujia-Longgumuli decoction on brain-derived neurotrophic factor (BDNF) levels and neurological function in patients with post-stroke depression (PSD). Methods Patients meet the diagnostic criteria of the PSD were randomly recurited into a control group and a study group.The control group received conventional therapy. On this basis, the study group was treated with Chaihujia-Longgumuli decoction.The levels of serum BDNF,Hamilton Depression Scale(HAMD-24), neurological impairment rating scale (MESSS), stroke rehabilitation assessment of movement table (STREAM) rate situation and clinical efficacy were compared between the two groups. Results After treated for 3 weeks and 6 weeks,the serum BDNF level in the study group was significantly higher(t=2.52、 2.14. P＜0.05) than the control group, while HAMD score was significantly lower than the control group(t=2.07、3.02,P＜0.01). MESSS score in the study group was also significantly lower than control group (t=2.51、4.50, P＜0.01). After 6 weeks treatment both STREAM score(t=2.01, P＜0.05) and the therapeutic effects (x2=7.93,P＜0.05) showed significant difference between the two groups. Conclusion Chaihujia-Longgumuli decoction can increase serum BDNF levels, reduce depression, improve nerve and motor function and boost clinical efficacy.

Objective To investigate the effect of the degree of social support on treatment compliance, efficacy and quality of life in patients with irritable bowel syndrome. Methods A total of 67 patients diagnosed of Rome II irritable bowel syndrome (IBS) were recruited into a low social support group (<35) and a high social support group (>45) according to the total score of social support. Treatment compliance, the World Health Organization Quality of Life BREF Determination (WHOQCL-BREF) and the clinical efficacy respectively were measured and compared between the two groups. Results The treatment compliance of patients with IBS in SSRS high score group was (13.79±5.12). While the treatment compliance of IBS patients in SSRS low score group was (11.25± 4.28). The difference between the two groups was significant (t=2.01, P<0.05).WHOQCL-BREF physical field, psychological field, social relations field and the environment field of IBS patients in SSRS high score group were significantly higher than the SSRS low score group (P<0.05) . Obvious effective rate, effective rate, and total effective rate in SSRS high score group were also higher than the low SSRS score group, with a significant difference (P<0.05) . The subjective Support, objective support, support availability factors of social support have significantly positive correlations (P<0.05 or 0.01) with the treatment compliance and all WHOQCL-BREF factors except environment; WHOQCL-BREF environmental factor was only related with the objective support (P<0.05) . Conclusion A good effective social support is of great significance in improving treatment compliance , quality of life and clinical efficacy in patients with IBS.