The pathogenesis of viral myocarditis is still not fully understood so far.However,the viral damage to the myocardial cells directly and immune-mediated injury of the myocardium have been a consensus.In recent years,the genetic susceptibility in the pathogenesis of viral myocarditis has attracted more and more attention.This review summarizes the research progress of the genetic susceptibility at home and abroad.

Homing and engraftment of transplanted hematopoietic stem cells (HSCs) can directly influence the effect of the transplantation.Exploration on its spatial distribution,location and interaction with the bone marrow (BM) microenvironment is great significance.Since the BM cavity is closed and surrounded by thick compact bone,it makes a colossal challenge to track the transplanted HSCs in vivo directly.Recently,researchers used different innovative methods to observe the spatial distribution and interaction with the BM microenvironment of the transplanted HSCs.The present review summarized the progress in the HSCs transplantation.

Kawasaki disease (KD) is an acute systemic vasculitis and its main life-threatening complications are coronary artery lesions(CAL), including coronary artery stenosis, thrombosis, aneurysm rupture, or sudden death. KD has now surpassed acute rheumatic fever as the leading cause of acquired heart disease in children. Therefore, it is important to identify as early as possible KD patients who are at risk for the development of CAL and intervent them timely. Genetic factors are thought to have important influences on the development and progress of Kawasaki disease and its CAL. In previous reports, several genetic polymorphisms, such as VEGF, MMPs and CD14 gene, were associated with the development of CAL. This review will introduce the study of gene polymorphisms in susceptibility to CAL in children with KD recently.

Objective A survey was conducted to explore the relationship between research capacity and clinical practice in local public hospitals.Methods A third grade class A hospital from Yangzhou city was selected as an example;and 357 medical staff were surveyed through a designed questionnaires.Results Data collected by questionnaires was analyzed to understand the relationship between research ability and clinical practice as well as the awareness of the hospital staff.The results showed that the hospital staff realized that such relationship should be positively associated with each other, and mutual penetration.Conclusions Recommendations have been raised to promote research ability, and then enhance the quality of clinical practice.

Objective To analyze the curative effect and safety of the estrogen as an adjunctive treatment of senile vaginitis.Methods 100 patients with senile vaginitis in our hospital from June 2011 to September 2012 were divided into observation group (n =50) and control group (n =50).Observation group was given estrogen plus metronidazole and control group was given metronidazole only.Results 45 cases were cured and 4 cases had effective treatment in observation group,and 21 cases were cured and 17 cases had effective treatment in control group.The efficacy rate was 98.0％ (49 cases)in observation group versus 76.0％(38 cases) in control group (x2=11.50,P＜0.01).After the treatment,the recurrence rate was 6.1％ (3 cases)and 26.3 ％ (10 cases)in observation and control groups respectively (x2 =10.66,P＜0.05).After treatment,vaginal health scores,symptom scores of vaginitis,and vaginal PH were significantly higher in the observation group than in the control group (all P＜0.05).In addition,the improvements of signs and symptoms were significantly better in the observation group than in the control group (all P＜0.05).However,there was no significant difference in adverse reaction rate between the two groups (P＞ 0.05).Conclusions Estrogen as an adjunctive treatment of senile vaginitis has better curative effect and safety.It is worthy of generalization in clinical medicine.

ObjectiveTo observe the effect of amlodipine besylate combined with benazepril in treatment of old patients with primary hypertension and left ventricular hypertrophy,and analyze the safety.MethodsOne hundred and eight old patients with primary hypertension and left ventricular hypertrophy were divided into observation group(54 cases) and control group(54 cases) by random digits table.The patients in observation group were treated with amlodipine besylate combined with benazepril and the patients in control group were only treated with amlodipine besylate.The levels of blood pressure,interventricular septal thickness(IVST),left ventricular posterior wall (LVPW),left ventricular end-diastolic dimension (LVEDD) and left ventficular mass index(LVMI) before and after treatment for 6 months were measured and compared between two groups.The adverse effects after treatment were compared too.ResultsAfter treatment,the levels of 24hSBP,24hDBP,IVST,LVPW,LVEDD and LVMI were significantly decreased in both groups (P ＜ 0.05).Moreover,the levels of 24hSBP,24hDBP,IVST,LVPW,LVEDD and LVMI after treatment in observation group were significantly lower than those in control group(P ＜ 0.05).There was 1 case ( 1.9％ ) of dry cough,2 cases (3.7％) of mild ankle edema in observation group,while only 2 cases (3.7％) of mild ankle edema in control group.There was no significant difference in adverse effects between two groups (P ＞ 0.05).ConclusionsCompared with amlodipine besylate single treatment,amlodipine besylate combined with benazepril in treatment of old patients with primary hypertension and left ventricular hypertrophy can more effectively control blood pressure and reverse left ventricular hypertrophy.The adverse effects are not increased,which can be applied in clinic.

The management of extremely low birth weigh infants is challenging,including how to communicate with family members,cooperation between pediatric and obstetrics,overall NICU management level,targeted and personalized management mode,and etc.In this article,clinical management experience for extremely low birth weigh infants was summarized,such as management at birth,stabilization of body temperature after birth,prevention and treatment of intracranial hemorrhage,infection,and blood transfusion management,as well post-discharge management.

Insulin resistance is the fundamental defect of type 2 diabetes and often leads to hyperinsulinemia, which is associated with atherosclerosis and cardiovascular events. A multidisciplinary approach involving multifaceted therapeutic strategies is necessary to reduce cardiovascular events and to improve prognosis in these patients. The purpose of this review is to outline proven and promising therapeutic strategies for improving the long-term cardiovascular prognosis of patients with type 2 diabetes.

Th17 is a CD4+ T cell subset that is a new member of Th1 and tH2.Recent studies have shown that it products IL-17A,IL-17F,IL-21 and IL-22,which play an imoortant role in rheumatoid arthritis.systemic lupus erythematosus,systemic sclerosis,inflammatory howel disease.autoimmune myocarditis and other autoimmune diseases.Deepen the understanding of Th17 and Th17 production in the advancement of autoimmune diseases will provide a new basis for future diagnosis.Th17 will become a new target for the treatment of human autoimmune diseases.

Ghrelin is involved in the process of feeding behavior and regulation of related energy metabolism,it also modulates the secretion of gonadotropins or transmitters concerning sex hormone releasing.It is considered as the factor connecting the HPG axis and energy metabolism.Body's nutrition has a bearing upon the process of reproductive system's onset and maturation.Adequate body weight is necessary for normal puberty onset.Obese children tend to have an earlier menarche.Ghrelin may pass on the information about nutrition to the hypothamalus in puberty onset.