1.Anatomical Variations of the Nose in Children Receiving Endoscopic Sinus Surgery
Na LI ; Min CHEN ; Yanting YAO
Chinese Journal of Minimally Invasive Surgery 2001;0(02):-
Objective To evaluate the outcomes of endoscopic sinus surgery (ESS) for children with chronic rhinosinusitis, who had no response to medication. Methods A total of 112 children (aged 12 to 17 years) with chronic rhinosinusitis caused by abnormal anatomy of the nose cavity were treated by ESS in our hospital. Septorhinoplasty was performed on the patients under an endoscope. Conchoplasty, adenoidectomy, or nasal polypectomy was performed simultaneously if necessary. Results The patients were followed up for 6-23 months (mean 13 months). The symptoms of rhinosinusitis disappeared in 110 patients (98.2%); whereas the other 2 patients showed no obvious improvement after the operation. Conclusions By using microinvasive ESS combined with conchoplasty, children with rhinosinusitis caused by abnormal anatomy that does not respond to medication could be cured.
2.The complications of traumatic optic neuropathy
Na LI ; Min CHEN ; Yan JIANG ; Yanting YAO
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2009;(16):743-745
Objective:To investigate the complications of traumatic optic neuropathy and to call the surgeons' attention to precaution. Method:Retrospectively analysis of 122 cases patients with traumatic optic neuropathy and 3 cases were analyzed in detail including 1 case with purulent meningitis, another 1 case with internal carotid artery pseudoaneurysm and the other 1 case with internal carotid artery cavernous sinus fistula. Result:Most of the patients had the complications of orbital fracture, maxillofacial fracture, ocular and craniocerebral injury. A few of patients had other injuries all over the body. The case with purulent meningitis was cured with antibiotics. The case with internal carotid artery pseudoaneurysm was cured with neurosurgery. The visual acuity of the both cases were improved. The case with internal carotid artery cavernous sinus fistula died of severe hemorrhea. Conclusion: The patient with traumatic optic neuropathy has the possibility of severe cranial disorders,orbital fracture, maxillofacial fracture and injuries of viscera or limbs. It should be paid mare attention and treated accordingly.
3.Influence of the physical growth and neuropsychological characteristic in children with obstructive sleep apnea hypopnea syndrome.
Ying TIAN ; Na LI ; Yan SUN ; Mingji YI ; Yanting YAO
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2008;22(23):1063-1067
OBJECTIVE:
To explore the influence of obstructive sleep apnea hypopnea syndrome (OSAHS) on physical growth and neuropsychological characteristic of children.
METHOD:
Eighty-two cases with OSAHS were examined by PSG, and divided to mild, moderate and severe group according to AHI, and 40 healthy children were selected as control group. Physical and mental development were evaluated on the basis of growth and neurodevelopmental assessments, respectively. Psychological behavior were assessed by Wechsler Intelligence Scale for Children Chinese Version and Achenbach Child Behavior checklist.
RESULT:
(1) The children of mild group were lower than the control group in the height and sitting height. The children of moderate and severe group were significantly lower than the control group in physical growth. (2) The children of mild group showed no difference compared with control group in Wechsler Intelligence Scale test. The moderate group were lower than control group in some test. Mean verbal IQ (VIQ), performance IQ (PIQ) and total scores in cognitive tests for severe groups were within the normal range, but lower than those of controls. (3) Melancholy, disobey, schizophreniform anxiety and offensive behavior were more common in male children with OSAHS than controls. While, offensive behavior, hyperactivity and aggressive behavior were more common in female children with OSAHS than controls.
CONCLUSION
The physical growth and neuropsychological characteristic can be influenced by obstructive sleep apnea hypopnea syndrome in children, and treatment ought to be done as early in case of the severity of the disease is aggravated.
Case-Control Studies
;
Child Behavior
;
Child, Preschool
;
Female
;
Humans
;
Intelligence Tests
;
Male
;
Polysomnography
;
Severity of Illness Index
;
Sleep Apnea, Obstructive
;
physiopathology
;
psychology
4.The complications of traumatic optic neuropathy.
Na LI ; Min CHEN ; Yan JIANG ; Yanting YAO
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2009;23(16):743-745
OBJECTIVE:
To investigate the complications of traumatic optic neuropathy and to call the surgeons attention to precaution.
METHOD:
Retrospectively analysis of 122 cases patients with traumatic optic neuropathy and 3 cases were analyzed in detail including 1 case with purulent meningitis, another 1 case with internal carotid artery pseudoaneurysm and the other 1 case with internal carotid artery cavernous sinus fistula.
RESULT:
Most of the patients had the complications of orbital fracture, maxillofacial fracture, ocular and craniocerebral injury. A few of patients had other injuries all over the body. The case with purulent meningitis was cured with antibiotics. The case with internal carotid artery pseudoaneurysm was cured with neurosurgery. The visual acuity of the both cases were improved. The case with internal carotid artery cavernous sinus fistula died of severe hemorrhage.
CONCLUSION
The patient with traumatic optic neuropathy has the possibility of severe cranial disorders, orbital fracture, maxillofacial fracture and injuries of viscera or limbs. It should be paid more attention and treated accordingly.
Adolescent
;
Adult
;
Child
;
Craniocerebral Trauma
;
complications
;
Female
;
Humans
;
Male
;
Middle Aged
;
Neurosurgical Procedures
;
Optic Nerve Injuries
;
complications
;
surgery
;
Retrospective Studies
;
Young Adult
5.In Vitro and In Vivo Study on the Effect of Lysosome-associated Protein Transmembrane 4 Beta on the Progression of Breast Cancer
Deyou TAO ; Junqing LIANG ; Yihong PAN ; Yanting ZHOU ; Ying FENG ; Lin ZHANG ; Jingjing XU ; Hui WANG ; Ping HE ; Jie YAO ; Yang ZHAO ; Qinjie NING ; Wen WANG ; Wei JIANG ; Jing ZHENG ; Xia WU
Journal of Breast Cancer 2019;22(3):375-386
PURPOSE: Although the effect of lysosome-associated protein transmembrane 4 beta (LAPTM4B) on the proliferation, migration, and invasion of breast cancer (BC) cells has already been studied, its specific role in BC progression is still elusive. Here, we evaluated the effect of different levels of LAPTM4B expression on the proliferation, invasion, adhesion, and tumor formation abilities of BC cells in vitro, as well as on breast tumor progression in vivo. METHODS: We investigated the influence of LAPTM4B expression on MCF-7 cell proliferation, invasion, adhesion, and tube formation abilities in vitro through its overexpression or knockdown and on breast tumor progression in vivo. RESULTS: Cell growth curves and colony formation assays showed that LAPTM4B promoted the proliferation of breast tumor cells. Cell cycle analysis results revealed that LAPTM4B promoted the entry of cells from the G1 into the S phase. Transwell invasion and cell extracellular matrix adhesion assays showed that LAPTM4B overexpression increased the invasion and adhesion capabilities of MCF-7 cells. More branches were observed in MCF-7 cells overexpressing LAPTM4B under an electron microscope. In comparison with LAPTM4B overexpression, LAPTM4B knockdown decreased the expression of vascular endothelial growth factor-A and significantly inhibited the vasculogenic tube formation ability of tumors. These results were also verified with western blot analysis. CONCLUSION: LAPTM4B promoted the proliferation of MCF-7 cells through the downregulation of p21 (WAF1/CIP1) and caspase-3, and induced cell invasion, adhesion, and angiogenesis through the upregulation of hypoxia-inducible factor 1 alpha, matrix metalloproteinase 2 (MMP2), and MMP9 expression. This specific role deems LAPTM4B as a potential therapeutic target for BC treatment.
Blotting, Western
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Breast Neoplasms
;
Breast
;
Caspase 3
;
Cell Cycle
;
Disease Progression
;
Down-Regulation
;
Extracellular Matrix
;
Hypoxia-Inducible Factor 1
;
In Vitro Techniques
;
Matrix Metalloproteinase 2
;
MCF-7 Cells
;
S Phase
;
Up-Regulation
;
Vascular Endothelial Growth Factor A
6. The relationship among depression, anxiety, stress and addictive substance use behavior in 5 935 secondary vocational students
Xiaodong YU ; Jincong YU ; Qingfeng WU ; Jiayan CHEN ; Yuncui WANG ; Dong YAN ; Shiwei TENG ; Yanting ZHAO ; Jiepin CAO ; Shuaiqi LI ; Yaqiong YAN ; Jie GONG ; Kang YAO ; Hui ZHOU ; Zengzhen WANG
Chinese Journal of Preventive Medicine 2017;51(3):226-231
Objective:
To investigate the relationship among depression, anxiety, stress and addictive substance use behavior in secondary vocational students.
Methods:
Cluster sampling method and the Adolescent Health-related Behaviors Questionnaire were used to collect demographic characteristics, psychological symptoms, and addictive substance usage among 5 935 students in nine vocational schools in Chongqing, Zhaoqing, Ningbo, and Taiyuan. Multivariate logistic regression analysis was used to analyze the relationship between the addictive substance use behavior and psychological factors.
Results:
The detection rates of depression, anxiety and stress were 46.5% (