BACKGROUND:The pathogenesis and risk factors for lumbar disc herniation are significantly different between adults and teenagers Previous studies seldomly refer to risk factors for lumbar disc herniation in adolescents by using logistic regression analysis.OBJECTIVE:To investigate the risk factors for lumbar disc herniation in adolescents in Jinzhou by using logistic regression analysis.METHODS:A total of 94 patients with lumbar disc herniation,including 56 males and 38 females,aging 9-18 years,were considered as the experimental group.A total of 1 00 patients suffering from other diseases were considered as the control group.Logistic regression analysis was employed to analyze risk factors for lumbar disc herniation onset,suggesting that OR>1 was taken as the risk factor for lumbar disc herniation,whereas OR<1 as the protective factor for lumbar disc herniation RESULTS AND CONCLUSION:All the 1 94 patients were involved in the final analysis.The result of logistic regression analysis showed that compared with control groups,the patients with lumbar disc herniation were statistically associated with familial Dredisposition(OR=6.427,P=0 015),trauma(OR=17.196,P=0.011),congenitalmalformations(OR=31.429,P=0 002),and over-exercise(OR=12.644,P=0.027)Trauma,congenital malformations,familial predisposition,and over-exercise were the risk factors for lumbar disc herniation in children and adolescents in Jinzhou.So it is necessary to implement a comprehensive prevention program,such as lifestyle and dietary habit modification,and proper activity.

Translational medicine is an emerging idea in current medical research area. Typically, for the purpose of bridging the gap between basic and clinical research, it not only emphasizes the urgency and necessity to break the traditional working formats, including single subject centered research team and limited cooperation among different scientific groups, but also highlights a more close and frequent interaction between basic scientist and clinician. In order to reach this goal, the theory and method of systems biology should be employed. This paper mainly focused on a central issue that how to carry out an investigation on early clinical diagnosis of xenobiotic-induced intrauterine growth retardation (IUGR) by using research concept of translational medicine and method of systems biology. Briefly, a hypothesis of common mechanism of IUGR was first proposed and subsequent validation was performed via integrating--omics (e.g. genomics, proteomics, cytomics, metabonomics/metabolomics) and molecular biology techniques. Metabonomics was further utilized to explore IUGR biomarker and establish preliminary forecasting model by bioinformatics and computational biology, which is available for early diagnosis of IUGR and make a complement to current evaluation criteria.

Recent studies on the role of viable myocardium in revascularization are hot spots.The definition of viable myocardium,multimodality imaging in the assessment of myocardial viability,Meta analyses related to the value of viable myocardium in revascularization,prospective randomized trials,and factors affecting the prognosis of patients after revascularization are reviewed in this article.

Objective To formulate the quality standard of Rukang Capsule. Method The TLC of Zhebeimu, Xuanshen, Ruxiang and Tiandong were done separately. The HPLC-ELSD was used to determine the content of Astragaloside in Mongolian Milkretch Root. Result There were the same spots between the controls and samples and an excellent linear relationship for 1.44～4.32 ?g to the content determination of Astragaloside. The average recovery can reach 100.3% with 0.5% of RSD. Conclusion This method is reliable and accurate to application, and can be used for the quality control of the preperation.

Objective To explore the establishment and effectiveness of school-based training bases.Methods Two hundred forty-six nursing students having finished theoretical learning and possessing into clinical practice were divided into the control group(n=121)and the observation group(n=125).The control group received the conventional training in out-school training bases and the observation group in the school-based training bases.The two groups were compared in terms of creative thinking and the performances of nursing theory,manipulations and assessed by their teachers.Result The scores on creative thinking and the performances in nursing theory and manipulation in the observation group were both significantly higher than the control group(P<0.05)and the assessment by teachers in the observation group was better than the control group.Conclusion The school-based training base used for nursing teaching can not only improve the nursing theory and manipulation of nursing students but also improve the creative thinking.

[Objective]To investigate the pathogenesis,pathology,diagnosis and therapy of hyponatremia after acute spinal cord injury.[Method]Fifteen in-patients with hyponatremia after acute spinal cord injury from 2004 to 2006 were retrospectively analyzed.[Result]Serum sodium was lower than 130 mmol/L in all cases.Urine sodiumcanned was from 40 to 68 mmol/L and urine osmotic pressure was from 420 to 980 mmol/L.After limitation of water intake and appropriate salt intake,12 patients recovered at 2 to 3 weeks.Because of fever and avoiding limitation of water intake,the other 3 patients recovered slowly.[Conclusion]The more serious the acute spinal cord injury,the higher the frequency of hyponatremia;syndrome of inappropriate antidiuretic hormone secretion(SIADH) is its primary cause: appropriate measures should be taken to correct the hyponatremia according to the findings of serum sodium and urine osmotic pressure.

Objective To investigate the feasibility of repairing spinal tracts with peripheral nerve graft combing neurotrophic factors in rats following complete spinal cord transection.Methods One hundred and twenty-one male Wistar Rats were transection at T9 level of spinal cord, and randomly divided into five groups. Group A with spinal cord transection was underwent acidic fibroblast growth factor (aFGF) treatment and peripheral nerve grafts (n=25); Group B: spinal cord transection was underwent aFGF treatment only (n=25); Group C: spinal cord transection was underwent peripheral nerve grafts only (n=25); Group D: spinal cord transaction only (n=25); and Group E: sham control (laminectomy only, n=21). The locomotor behavior of all rats was analyzed by the BBB open field locomotor test over the six months of survival time. Motor evoked potentials (MEP) were used to evaluate axon growth across the damage site. Biotinylated Dextran Amine (BDA) and retrograde tracing with fluorogold were used to evaluate the presence of axons through the damage site after treatment. Results The presence of anterograde BDA labeling of corticospinal tract axons at the graft site and fluorogold retrograde labeling of neuron populations was found in motor cortex and in red nucleus, reticulospinal nuclei, raphe nuclei, and vestibular nuclei in Group A. The average latency and amplitude of MEP were improved significantly in Group C. The mean of BBB scores showed significant improvement in Group A. Statistical analysis indicated that Group A had significant improvement compared to Group BC and D at 6 months post-surgery (P

0 05). The levels of TC, LDL-C and apoB in the patients with CSX were significantly higher than those in the patients with CN(P

Objective To survey the Keshan disease conditions and its trend in the historical serious illness areas of the disease in Arong Banner,and to provide epidemiological evidence for scientific prevention and control of Keshan disease.Methods According to the requirements of National Keshan Disease Surveillance Program,two villages in 2 townships of Arong Banner were selected as monitoring sites in 2012,population in monitoring sites was conducted clinical examination and electrocardiogram (ECG) tracings;suspected cases of Keshan disease were conducted chest X ray and ultrasound heartbeat graph examination.At the same time,residents' income and staple food structure were investigated.Results The abnormal rate of ECG was 7.92％ (66/833).The detection rate of cardiac enlargement was 20.00％ (9/45) by chest X ray,in which a slight increase was 8.89％ (4/45),moderate increase was 4.44％ (2/45) and severe increase was 6.67％ (3/45).The detection rate of Keshan disease patients was 132.05/10 000 (11/833),including latent Keshan disease [72.03/10 000 (6/833)] and chronic Keshan disease [60.02/10 000 (5/833)].In the ECG abnormal changes of Keshan disease cases,ST-T change and right bundle branch block were common,accounting for 100.00％ (11/11) and 63.64％ (7/11),respectively;frequent ventricular premature contraction was 2 cases,accounting for 18.18％ (2/11),degree I ° atrioventricular block and complete left bundle branch block was both i case,accounting for 9.09％ (1/11).Annual per capita income in Arong Banner was 8 100 yuan;dweller staple food was rice,flour and other grain crops,rice accounted for 70％-80％,flour 15％-25％ and purchased non-local grain accounted for 95％.Conclusions Keshan disease has been under control at a lower level in Arong Banner,but new latent and chronic Keshan disease occur slowly,gradually and gradually accumulated;life quality and dietary structure have influence on the incidence.In the future,we should pay more attention to Keshan disease and do a good job on prevention and control of Keshan disease.

Objective To explore clinical characteristics of H-type hypertension in health check-up populations so as to provide evidence for stroke prevention.Methods A total of 42 251 health check-up individuals (male 27 746,female 14 505,average age (46 ± 9) years) who visited our center during May,2009 and February,2012 were enrolled and responded to the investigation.In face to face interview,their age,gender,cigarette smoking and alcohol consumption were recorded.Height,body weight and blood pressures were measured.Serum lipid profiles,blood glucose,uric acid (UA),creatinine (Cr),homocysteine and urine albumin creatinine ratio (ACR) were tested.The subjects were then assigned to the H-type hypertension group,common hypertension group,high homocysteine group and control group.Analysis of Variance was used for data analysis.Results Of 42 251 participants,7748 were found to have H-type hypertension (18.34％ in whole subjects and 63.95％ in hypertensive subjects).Serum level of homocysteine and prevalence of common hypertension and H-type hypertension were significantly higher in males (P ＜ 0.05).Age and body mass index of the H-type hypertension group were significantly increased (P ＜ 0.05).The highest incidence of cigarette smoking and alcohol drinking was found in the homocysteine group (P ＜ 0.05),while the highest serum levels of Hb,UA,high sensitivity-C reactive protein (hs-CRP),and Cr occurred in the H-type hypertension group.Moreover,total cholesterol,triglycide,low-density lipoprotein cholesterol,and microalbumin/creatinine were not significantly different between the common hypertension group and the H-type hypertension group (P ＞ 0.05),although were significantly different between the controls and the H-type hypertensive patients (P ＜ 0.05).Conclusion The prevalence of Htype hypertension may be increased with the increasing serum levels of biological markers for nutritional metabolism.Higher level of homocysteine dose not seem to aggregate lipid disorders and early renal damage.