The character of exposure-response relationship between particulate matter and population mortality has been one of the critical and difficult problems in air pollution epidemiological study. The character of exposure-response relationship included the shape of the exposure-response relationship and the existence of the threshold concentration. In this paper, the recent relevant researches on the character of exposure-response relationship between particulate matter and population mortality were reviewed. The threshold concentration of particulate matter for mortality was not found and the shape of the exposure-response curve need to be further studied. Now, in China, we are facing a good opportunity for researching the exposure-response relationship between particulate matter and population mortality.

Objective:To explore the therapeutic effect of intra-aortic balloon counterpulsation (IABP)on acute my-ocardial infarction (AMI)complicated pump failure.Methods:Clinical data of 82 AMI patients complicated pump failure,which received emergency percutaneous coronary intervention (PCI)in our hospital from Jan 2010 to Oct 2013,were retrospectively analyzed.The patients were divided into IABP group (n=42,received PCI with auxiliary IABP)and routine PCI group (n=40,only received routine PCI therapy).Success rate of treatment,mortality,he-modynamic conditions [systolic blood pressure (SBP),diastolic blood pressure (DBP)and heart rate (HR)]stable to PCI time,length of hospital stay and complications were compared between two groups.Results:Compared with routine PCI group after treatment,there were significant rise in blood pressure [SBP: (80.3± 16.2)mmHg vs. (88.4±12.5)mmHg,DBP:(55.4±10.2)mmHg vs.(60.0±10.5)mmHg]and urine volume [(30.2±8.3)ml/h vs.(40.3±9.4)ml/h],and significant reduction in HR [(92.4±26.1)times/min vs.(80.5±18.5)times/min] in IABP group,P <0.05~<0.01;there was significant increase in success rate (72.5% vs.83.3%),and signifi-cant decrease in mortality rate (27.5% vs.16.7%),time stable to PCI for hemodynamical condition [(10.1±8.1) h vs.(5.0±2.5)h]and length of hospital stay [(18.4±6.2)d vs.(13.5±4.2)d]in IABP group,P <0.05 all;incidence rate of complications was no significant difference between groups (P >0.05).Conclusion:IABP adjuvant treatment helps to raise success rate of PCI,improve hemodynamic condition and increase urine volume,shorten length of hospital stay in patients with AMI complicated pump failure.

To explore novel histone deacetylase (HDAC) inhibitors with anti-tumor activity, twelve target compounds were synthesized, and their structures were confirmed by 1H NMR, MS and elemental analyses. Evaluation results in vitro showed that compound Ia exhibited potent inhibition against HDAC and is worth for further investigation. And compounds IIa, IIb, IIIa-IIIi possessed moderate HDAC inhibitory activity.

Objective To observe expressions of Smad gene and protein in skin pathological scar. Methods Every ex-perimental samples were obtained from 136 patients,who underwent scar resection or were recruited healthy people,from April 2010 to April 2014,including 47 patients with keloid,44 patients with hypertrophic scar,45 healthy people. Each sample was taken by RT-PCR and flow cytometry and results were analyzed. Results The expressions of Smad3 and TGF-β1 gene showd that keloid group and hypertrophic scar group were more than normal skin group,the differ-ences were significant(P<0.05). Conclusion The expressions of Smad3 and TGF-β1 are important characters of hyper-trophic scar and keloid.