Objective To compare the ischemia-modified albumin(IMA)level between T2DM and AMI,and to discuss the possible mechanism and pathology process.Methods According to the decrease of power of albumin binding cobalt along with the increase of ischemia-modified albumin,the automated continuous detection of free cobalt in reactive system were conducted using the 480nm wavelength and the results were reported as absorbance unit(ABSU)and coloration rate of free cobalt.Results There were significant differences in serum free cobalt between the control and groups of acute coronary syndrome(ACS)and type 2 diabetes and between ACS and type 2 diabetes(P

Objective To explore the changes of insula function integration in patients with chronic insomnia (CI) using functional connectivity (FC) analysis in resting-state fMRI. Methods Totally 22 patients with CI (CI group) and 23 healthy volunteers (control group) underwent resting-state fMRI. The templates based on Chinese brains (Chinese2020) were used for spatial standardization. The bilateral insulae were selected as ROIs, and FC analysis was performed with other voxels to obtain brain regions with abnormal FC between the two groups. Correlation analysis was performed between the brain regions with abnormal FC and clinical parameters. Results Compared with control group, the increased FC brain regions with right insula in CI group included bilateral hippocampus, bilateral parahippocampus, bilateral frontal middle gyrus, right temporal middle gyrus, right precentral gyrus, left temporal inferior gyrus, left fusiform gyrus and left posterior lobe of cerebellum (all P<0.05, number of voxel cluster ≥10, AlphaSim correction), while the increased FC brain regions with left insula in CI group included bilateral hippocampus, bilateral parahippocampus, left fusiform gyrus, left temporal inferior gyrus, left posterior lobe of cerebellum and right anterior lobe of cerebellum (all P<0.05, number of voxel cluster ≥10, AlphaSim correction). Correlation analysis showed the scores of instantaneous memory in CI group were positively correlated with FC of the right insula-right hippocampus, right insula-left hippocampus, left insula-right hippocampus and left insula-left hippocampus (r=0.580, 0.668, 0.454, 0.562, all P<0.05). Conclusion FC is abnormal between the bilateral insulae and multiple brain regions in CI patients, therefore providing neuroimaging evidence for understanding emotional regulation, cognitive impairment, daytime dysfunction and impaired memory mechanisms in CI.

Objective To explore the changes of brain functional network in insomnia disorder (ID) during resting-state with voxel-based degree centrality (DC).Methods Forty-five subjects underwent resting-state fMRI scans,including 22 patients with ID (ID group) and 23 sex-,age-,and education-matched healthy volunteers (control group).The subjects' sleep quality and emotion state were assessed with Pittsburgh sleep quality index (PSQI),Hamilton anxiety scale and Hamilton depression scale.The resting-state fMRI data were analyzed with voxel-based DC.The intra-and inter-groups parameters were compared using t-test.Correlation analysis was performed between DC values of ID group and clinical parameters.Results Compared with control group,DC values increased in left parahippocampal gyrus,left hippocampus and bilateral precuneus (all P＜0.05),while decreased in left middle occipital lobe,left precuneus,left inferior frontal gyrus and left middle frontal gyrus in ID group (all P＜0.05).DC values of the left hippocampus in ID patients showed significantly negative correlation with the score of Pittsburgh sleep quality index (r=-0.46,P=0.047).Conclusion ID patients have abnormal DC distribution of brain functional network,therefore providing basis for understanding pathophysiological mechanisms of ID.

Good sleep is essential for children′s physical and mental health, growth, and development.Adequate and high-quality sleep positively impacts children′s quality of life, memory, learning, attention, mood, and behavior.Children of different ages have different sleep needs.Children have various sleep problems in different cultures.Therefore, it is significant to guide children to get healthy sleep by popularizing the sleep problems of Chinese children of all ages and in all dimensions.Based on China′s social and cultural background, this paper summarizes the contents related to children′s sleep physiology, good sleep habits, common sleep problems, sleep apnea disorders, hypnagogic sleep, narcolepsy, insomnia, and other issues that interfere with children′s sleep.Chinese sleep experts summarize and interpret the 100 sleep health problems of children that medical workers and parents are most concerned about.To promote children′s sleep health and popularize solutions to sleep problems.