group was (1.20 ± 1.09),(1.09 ± 1.04), (0.86 ± 0.42), (1.89 ± 1.30) and that of the control group was (2.40 ± 1.87), (2.34 ± 1.71), (1.60 ± 1.33),(3.49 ± 1.72) respectively, which had statistical significance between the two groups (t=3.139-4.390, P<0.01). the Blood CRP values and CRP positive rate in the observation group, were (6.34±2.74) and 17.14%(6/35) respectively and which of the control group were (10.35±7.37) and 42.86%(15/35), the difference of the two groups was statistically significant (t=2.881, P<0.01 andχ2= 5.250, P < 0.05). Conclusions Topical treatment of acute cellulitis with honey can effectively improve the clinical symptoms, reduce the level of c-reactive protein, which is better than magnesium sulfate wet compress.

Objective To investigate the value of 18 F-fluorodeoxyglucose (18 FDG)positron emission tomography and computer tomography (PET/CT)in the diagnosis and localization of ectopic ACTH syndrome (EAS)induced by lung cancer,and to increase the accuracy rate of diagnosis of EAS.Methods 8 patients were histopathologically proven to be lung cancer.18 FDG PET/CT wholebody and brain scan were performed;magnetic resonance imaging (MRI),99m Tc-octreotide (OCT)imaging and inferior petrosal sinus sampling (IPSS)were done in all patients.On 18 FDG PET/CT images,the SUVmax values of lesions and the SUVmax ratio of lesion tissue to normal lung tissue were calculated.Results ① 8 patients with EAS included 2 cases of carciniod,4 cases of atypical carciniod,and 2 cases of small cell lung cancer.The ACTH levels in inferior petrosal sinus and peripheral veins of 8 patients had no difference.②The chest CT showed there were pulmonary nodules in 6 cases (75%),among them 2 cases were atypical lesions.5 cases of pituitary adenomas were found by MRI (25%),and OCT imaging was positive in 2 cases (25%).③The 18 FDG PET/CT showed nodular,mass like or patch samples with high metabolic activity in 8 cases (100%)of pulmonary lesions.The SUVmax of tumor was 0.72 to 14.05 (3.67±4.68),and the ratio of SUVmax of lesion tissue to normal lung tissue was 1.69 to 27.54 (8.14 ± 9.63).18 FDG hypermetabolism was found in 8 cases of bilateral adrenal hyperplasia,while 4 cases showed pituitary tumor.Conclusion Lung cancer is a common source of EAS,especially carcinoid.18 FDG PET may show lower glucose metabolism.18 FDG PET/CT should be used as an assisted method to diagnose EAS.

Objective To investigate the risk factors and establish the Cox's regression model and the personal prognosis index for the recurrence of ischemic stroke in 3-year follow-up.methods 1058 patients were retrospectively reviewed consecutively diagnosed with ischemic stroke admitted to the Neurology Department of the Hebei united University Affiliated Hospital from January 1,2013 to December 31,2013.Cases were followed up since the onset of ischemic stroke.The follow-up was finished in January 1,2016.Kaplan-Meier methods were used for recurrence rate description.Monovariant and multivariate Cox's proportional hazard regression model were used to analyze risk factors associated with recurrence.Thus,a recurrence model was set up.Result sDuring the period of follow-up,184 cases relapsed.The 1-year recurrence rate was 29.9 person-year,2-year recurrence rate was 46.6 person-year,3-year recurrence rate was 52.7 person-year.Monovariant and multivariant Cox's proportional hazard regression model showed that the independent risk factors associated with recurrence were age(X1)(RR=1.303;95%CI:1.019~1.666)history of heart disease(X2)(RR=1.788;95%CI:1.127~2.836),hypertension(X3)(RR=1.897;95%CI:1.097~3.280),diabetes(X4)(RR=1.674;95%CI:1.015~2.760),total cholesterol(X5)(RR=2.136;95%CI:1.396~3.266).The personal prognosis index(PI)of recurrence model was as the following: PI=0.265X1+0.581X2+0.640X3+0.515X4+0.759X5.Conclusion sAge,history of heart disease,hypertension,disease progression,and total cholesterol are the independent risk factors associated with recurrence of ischemic stroke.The recurrence model and the personal prognosis index equation are successful constructed.

Objective To explore the effects of humanistic care on preoperative negative emotions in patients undergoing eye surgery, so as to alleviate the negative emotion and promote the rehabilitation process of the operation. Methods From October 2016 to February 2017, totals of 120 patients who were undergoing eye surgery from each of the 2 wards of the ophthalmology department in the First Affiliated Hospital of Zhengzhou University were recruited in the research. All the patients were randomly divided into control group and observation group by coin tossing method. Routine nursing was applied in the control group, while on the basis of the control group, humanistic care was given to the observation group. The intervention effects were evaluated by the general information questionnaire, the Self-Perceived Burden Scale (SPBS), Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS). Results There was no statistical difference in negative emotions between the two groups before intervention (P>0.05). The scores of negative emotions all had a certain decrease after intervention. The scores of SPBS, SAS and SDS were (28.49±5.92), (45.49±6.49) and (41.22±5.62) in the observation group after intervention respectively; while those scores were (34.95±6.56), (58.57±8.56) and (54.53±6.45) in the control group respectively. The scores of the observation group were all lower than those of the control group, and the differences were statistically significant (t=10.49, 6.45, 7.34; P< 0.01). Conclusions Humanistic care can obviously reduce patients' self-perceived burden, anxiety, depression and improve patients negative emotions.

Objective To explore the correlation between depressive symptoms and frailty,in order to provide evidence for prevention and relief of depressive symptoms in elderly inpatients.Methods A cross-sectional survey and comprehensive geriatric assessment(CGA)were conducted with 248 eligible elderly inpatients from December 2015 to February 2017 in our hospital.Depressive symptoms were assessed by the 5-Item Geriatric Depression Scale(GDS-5),and frailty was identified by the frailty phenotype method.Results In all respondents,50 (20.2 ％)patients showed depressive symptoms,93(37.5 ％)patients had pre-frailty and 39 (15.7 ％)patients had frailty.Correlation analysis showed that frailty degree,low grip strength,slow gait speed,low physical activity,fatigue,and weakness were all positively correlated with depressive symptoms in elderly inpatients (r =0.441,0.315,0.426,0.316,0.395 and 0.151,respectively,P ＜ 0.05).Logistic regression analysis showed that patients who had more severe frailty faced a much higher risk of developing depressive symptoms (OR=2.608,P＜0.05).Of the 5 indicators of frailty,slow gait speed and frailty also increased the risk of having depressive symptoms (OR =2.801 and 3.484,P ＜ 0.05).Conclusions Frailty degree,gait speed and fatigue are associated with increased risk of depression in the elderly.Depressive symptoms can be reduced in elderly inpatients with prevention and intervention of pre-frailty and frailty.

Objective:To optimize the alcohol extraction process of herbal pair puerarin-berberine.Methods:Based on the etha-nol reflux extraction,the extraction quantity of total flavonoids,total alkaloid,puerarin and berberine hydrochloride were used as the e-valuation index,and the independent variables included the drug particle,ratio of solid to liquid, ethanol concentration, reflux dura-tion and reflux times. Significance analysis was evaluated by Plackett-Burman design,and then the extraction process was optimized by Box-Behnken response surface methodology.Results:The optimal extraction conditions of drug pair puerarin-berberine were as follows:the drug particle was 80 mesh,the ratio of solid to liquid was 1:13,the ethanol concentration was 75%,the reflux time was 60 min, and the reflux times was 4. Under the above conditions, the extraction quantity of total flavonoids, alkaloid, puerarin and berberine hydrochloride was 120.34,56.99,109.63 and 39.26 mg ·ml-1, respectively.Conclusion: The extraction process of herbal pair puerarin-berberine is reasonable and feasible optimized by Plackett-Burman design and Box-Behnken response surface methodology.

Objective To investigate the efficacy of Saccharomyces boulardii combined with ur-sodeoxycholic acid in the treating rectal ulcerative colitis(UC)and its influence on intestinal mucosal barrier function.Methods A total of 88 patients with rectal UC were randomly divided into observa-tion group and control group,with 44 cases in each group.The scores of main symptoms(abdominal pain,diarrhea,purulent stool),score of the Inflammatory Bowel Disease Questionnaire(IBDQ),lev-els of inflammatory factor indicators[interleukin-6(IL-6),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)]and levels of intestinal mucosal barrier function indicators[the ratio of urinary lac-tolic acid to mannitol(L/M),serum D-lactic acid(D-LA),serum diamine oxidase(DAO),and ser-um lipopolysaccharide(LPS)]were compared between the two groups before and after treatment.The incidence of adverse reactions were compared between two groups.Results After treatment,the scores of abdominal pain,diarrhea and purulent stool in both groups were significantly lower than those before treatment,while the IBDQ score was significantly higher than that before treatment,and the scores of abdominal pain,diarrhea and purulent stool in the observation group were significantly lower than those in the control group,while the IBDQ score was significantly higher than that in the control group(P＜0.05).After treatment,the levels of serum D-LA,DAO,LPS and urinary L/M in both groups reduced significantly,and the levels of these indicators in the observation group were signifi-cantly lower than those in the control group(P＜0.05).After treatment,the levels of serum IL-6,TNF-α and IL-1β in both groups reduced significantly,and the levels of these indicators in the observation group were significantly lower than those in the control group(P＜0.05).The total ef-fective rate inthe observation group was 86.36％,which was significantly higher than 68.18％in the control group(P＜0.05).There were no significant differences in incidence rates of adverse re-actions such as lower abdominal pain,allergies and refractory constipation between two groups(P＞0.05).Conclusion Saccharomyces boulardii combined with ursodeoxycholic acid is effective in the treatment of patients with rectal UC,which can effectively improve symptoms such as abdominal pain,diarrhea and purulent stool,inhibit the inflammatory response of the body,and alleviate dam-age to the intestinal mucosal barrier.

Objective To investigate the efficacy of Saccharomyces boulardii combined with ur-sodeoxycholic acid in the treating rectal ulcerative colitis(UC)and its influence on intestinal mucosal barrier function.Methods A total of 88 patients with rectal UC were randomly divided into observa-tion group and control group,with 44 cases in each group.The scores of main symptoms(abdominal pain,diarrhea,purulent stool),score of the Inflammatory Bowel Disease Questionnaire(IBDQ),lev-els of inflammatory factor indicators[interleukin-6(IL-6),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)]and levels of intestinal mucosal barrier function indicators[the ratio of urinary lac-tolic acid to mannitol(L/M),serum D-lactic acid(D-LA),serum diamine oxidase(DAO),and ser-um lipopolysaccharide(LPS)]were compared between the two groups before and after treatment.The incidence of adverse reactions were compared between two groups.Results After treatment,the scores of abdominal pain,diarrhea and purulent stool in both groups were significantly lower than those before treatment,while the IBDQ score was significantly higher than that before treatment,and the scores of abdominal pain,diarrhea and purulent stool in the observation group were significantly lower than those in the control group,while the IBDQ score was significantly higher than that in the control group(P＜0.05).After treatment,the levels of serum D-LA,DAO,LPS and urinary L/M in both groups reduced significantly,and the levels of these indicators in the observation group were signifi-cantly lower than those in the control group(P＜0.05).After treatment,the levels of serum IL-6,TNF-α and IL-1β in both groups reduced significantly,and the levels of these indicators in the observation group were significantly lower than those in the control group(P＜0.05).The total ef-fective rate inthe observation group was 86.36％,which was significantly higher than 68.18％in the control group(P＜0.05).There were no significant differences in incidence rates of adverse re-actions such as lower abdominal pain,allergies and refractory constipation between two groups(P＞0.05).Conclusion Saccharomyces boulardii combined with ursodeoxycholic acid is effective in the treatment of patients with rectal UC,which can effectively improve symptoms such as abdominal pain,diarrhea and purulent stool,inhibit the inflammatory response of the body,and alleviate dam-age to the intestinal mucosal barrier.

To design an electronic sleep massager that can perform massage and sleep aid at the same time.It is powered by a 9 V battery,and a multivibrator is composed of a 555 timer as the core to generate an oscillation signal.The 0～180 V continuously adjustable electrical pulse was output to the massage electrode through the step-up transformer,and the low-frequency sound signal was output through the speaker to achieve massage and sleep assistance.The electronic sleep massager has simple design and excellent performance,and uses sound hypnosis and acupressure massage at the same time,which can achieve relatively good hypnosis and fatigue relief effects,and is a small electronic health care product suitable for home use,and has certain promotion and application value.

Purpose: This study was performed to investigate the association of Glasgow prognostic score (GPS), combined positive score (CPS), and clinicopathological characteristics of locally advanced rectal cancer. Methods: Between February 2012 and February 2018, 103 patients with locally advanced rectal cancer treated by neoadjuvant chemoradiotherapy and total mesorectal excision (TME) were retrospectively evaluated. Results: According to the classification of the GPS, 85 (82.5%), 13 (12.6%), and 5 patients (4.9%) were classified as a score of 0, 1, and 2, respectively. Patients were classified into the GPS-low group (GPS of 0, n = 85) and GPS-high group (GPS of 1 or 2, n = 18) with an area under the curve of 0.582 for overall survival (OS). The mean programmed death-ligand 1 (PD-L1) CPS of the whole group was 2.24 (range, 0–70). The PD-L1 CPS of the GPS-high group was higher than the GPS-low group (P < 0.001). Multivariate analysis by Cox proportional hazards model indicated that GPS was associated with OS and diseasefree survival (DFS). Furthermore, PD-L1 CPS was associated with DFS (hazard ratio, 1.050; 95% confidence interval, 1.017– 1.083; P = 0.003). Conclusion Elevated GPS was related to the PD-L1 CPS. GPS and PD-L1 CPS were associated with the prognosis of locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy followed by TME.