1.The effect of training method of point-line-plane on development quotient in premature infants with brain injury
Yanran YUAN ; Ruigang ZHOU ; Pingping ZHAO ; Jihong DENG ; Yingwu LIANG
Chinese Journal of Behavioral Medicine and Brain Science 2016;25(12):1100-1103
Objective To evaluated the improving effect of training method of point-line-plane on development quotient in premature infants with brain injury.Methods 174 cases of premature children with brain injury were randomly divided into study group (89 cases) and control group (85 cases).Control group given Bobath and Vojta traditional rehabilitation training,and the study group was given training method of point-line-plane.Patients in both groups were evaluated synthetically based on The Evaluation Chart on Neu-robehavioral Development of Children Aged 0-6 Years,developed by Capital Institute of Pediatrics,prior to the treatment,and after the first,the second,and the third course of the training programs,respectively.Re-sults The score of developmental quotient ( DQ) between study group and control group was no significantly different(P>0.05).Compared with before treatment, the scores of DQ was significantly increased after the first, the second and the third course of training treatment in study group and control group((82.71±12.28) vs (81.17±9.63), t=0.859, P>0.05;(89.65±10.02) vs (87.02±7.39), t=1.747, P>0.05). Compared with the control group, the scores of DQ in study group was no significant difference after the first and the second course of treatment,but there was significantiy different after the third course treatment((95.26±8.87) vs (91.31±7.63), t=2.945, P=0.004).Conclusion The training method of point-line-plane can improve the clinical efficacy of premature infants with brain injury at the early phase, which is worth widely applying in clinical practice.
2.EIF5A2 Expression in Hepatocellular Carcinoma and Its Relation with Postoperative Survival
Qian YANG ; Dongxue YE ; Yanran MA ; Xiaoyuan HU ; Hong LI ; Xuan ZHOU ; Fenggang XIANG
Cancer Research on Prevention and Treatment 2021;48(6):617-624
Objective To detect the expression of EIF5A2 in hepatocellular carcinoma(HCC) and to explore its relation with clinicopathological characters and prognosis of HCC patients. Methods The expression of EIF5A2 mRNA and protein in 12 pairs of fresh HCC and corresponding non-tumor tissues adjacent to the cancer was examined by qRT-PCR and Western blot. The expression level of EIF5A2 in 284 pairs of HCC and adjacent non-tumor tissues was detected by IHC staining. Then we analyzed between EIF5A2 expression and clinical pathological parameters and prognosis of HCC patients. Results The relative expression levels of EIF5A2 mRNA and protein in fresh HCC tissues were significantly higher than those in the corresponding adjacent non-tumor tissues (
3.Exploratory study of tracheal extubation in operating room after single-lung transplantation
Yanran ZHOU ; Qinglong DONG ; Hanyu YANG ; Hui LIU ; Lei CHEN ; Yingfen LI ; Lei WU ; Xin XU ; Chao YANG ; Guilin PENG ; Mengyang LIU ; Lixia LIANG
Organ Transplantation 2022;13(2):246-
Objective To evaluate the feasibility and safety of tracheal extubation in operating room for patients with end-stage chronic obstructive pulmonary disease (COPD) after single-lung transplantation. Methods Clinical data of 57 recipients who underwent single-lung transplantation due to end-stage COPD were retrospectively analyzed. According to the evaluation indexes of tracheal extubation in operating room established by our hospital, 17 recipients eligible for tracheal extubation in operating room were assigned into the operating room extubation group (OR extubation group) and 40 recipients receiving tracheal extubation in intensive care unit (ICU) were allocated in the ICU extubation group. The evaluation results of intraoperative tracheal extubation and postoperative recovery were compared between two groups. Results Compared with the ICU extubation group, recipients in the OR extubation group had higher oxygenation index, lower arterial partial pressure of carbon dioxide (PaCO2), lower blood lactic acid level, less fluctuation range of blood pressure and fewer cases receiving extracorporeal membrane oxygenation (ECMO) during operation (all
4.Research progress on the correlation between transforming growth factor- β level and symptoms of depression.
Yanran LI ; Huiying WANG ; Jiansong ZHOU ; Changhong WANG
Journal of Zhejiang University. Medical sciences 2023;52(5):646-652
Transforming growth factor (TGF)-β is a group of cytokines with anti-inflammatory effects in the TGF family, which participates in the development of stress and depression-related mechanisms, and plays roles in the regulation of inflammatory response in depression and the recovery of various cytokine imbalances. The core symptoms of depression is associated with TGF-β level, and the psychological symptoms of depression are related to TGF-β gene polymorphism. Various antidepressants may up-regulate TGF-β level through the complex interaction between neurotransmitters and inflammatory factors, inhibiting inflammatory response and regulating cytokine imbalance to improve depressive symptoms. Studies have shown that recombinant TGF-β1 protein has beneficial effects in mouse depression models, indicating TGF-β1 might be a potential therapeutic target for depression and nasal sprays having the advantage of being fast acting delivery method. This article reviews the research progress on dynamic changes of TGF-β level before and after depression treatment and the application of TGF-β level as an indicator for the improvement of depressive symptoms. We provide ideas for the development of new antidepressants and for the evaluation of the treatment efficacy in depression.
Animals
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Mice
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Transforming Growth Factor beta/metabolism*
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Transforming Growth Factor beta1
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Depression
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Cytokines
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Antidepressive Agents/therapeutic use*
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Transforming Growth Factors
5. Efficacy and Safety of Prucalopride for Treatment of Chronic Functional Constipation: A Meta-analysis
Kaiyuan LI ; Yanran DU ; Yuyan ZHOU ; Chuanlian CHU ; Kaiyuan LI ; Chuanlian CHU ; Danlin SONG
Chinese Journal of Gastroenterology 2021;26(8):471-476
Background: Chronic functional constipation is a common functional gastrointestinal disorder, and the effects of traditional therapeutic drugs are suboptimal. Prucalopride is a novel 5-HT
6.Epidemiological characteristics of hand, foot and mouth disease Urumqi , Xinjiang , 2014-2022
Yakupu ABODUREZHAKE ; Yue WANG ; Hangyu ZHANG ; Yanran ZHOU ; Gulijiayina AIKEN ; Yaoqin LU
Journal of Public Health and Preventive Medicine 2024;35(5):46-50
Objective This study aims to analyze the epidemiological and etiological characteristics of hand, foot, and mouth disease (HFMD) in Urumqi City, Xinjiang from 2014 to 2022, in order to provide theoretical basis for the prevention and control of HFMD in Urumqi City. Methods We collected and analyzed the reported HFMD cases in Urumqi City from the National Information System for Infectious Diseases Reporting during the period of 2014-2022. Results A total of 17 138 cases of HFMD were reported in Urumqi City from 2014 to 2022, with an average annual incidence rate of 52.66/100 000. The overall trend showed a decrease, and the peak months were from May to July. The top three districts with the highest incidence rates were High-tech Zone, Shayibake District, and Tianshan District. The male-to-female ratio was 1.48:1,and there were statistically significant differences in the incidence rates among gender (χ2=2.28,P>0.05). The majority of cases (90.23%) were children aged 0-6 years, primarily scattered children, and other enterovirus strains became dominant after 2017. Conclusion HFMD has shown a decreasing trend in Urumqi City, Xinjiang in recent years. The disease primarily affects pre-school children, and other enterovirus strains have become the dominant strains in the area. It is recommended to develop scientifically effective prevention and control measures based on the local situation to control the spread of HFMD.
7.Aerobic glycolysis in colon cancer is repressed by naringin via the HIF1Α pathway.
Guangtao PAN ; Ping ZHANG ; Aiying CHEN ; Yu DENG ; Zhen ZHANG ; Han LU ; Aoxun ZHU ; Cong ZHOU ; Yanran WU ; Sen LI
Journal of Zhejiang University. Science. B 2023;24(3):221-231
Metabolic reprogramming is a common phenomenon in cancer, with aerobic glycolysis being one of its important characteristics. Hypoxia-inducible factor-1α (HIF1Α) is thought to play an important role in aerobic glycolysis. Meanwhile, naringin is a natural flavanone glycoside derived from grapefruits and many other citrus fruits. In this work, we identified glycolytic genes related to HIF1Α by analyzing the colon cancer database. The analysis of extracellular acidification rate and cell function verified the regulatory effects of HIF1Α overexpression on glycolysis, and the proliferation and migration of colon cancer cells. Moreover, naringin was used as an inhibitor of colon cancer cells to illustrate its effect on HIF1Α function. The results showed that the HIF1Α and enolase 2 (ENO2) levels in colon cancer tissues were highly correlated, and their high expression indicated a poor prognosis for colon cancer patients. Mechanistically, HIF1Α directly binds to the DNA promoter region and upregulates the transcription of ENO2; ectopic expression of ENO2 increased aerobic glycolysis in colon cancer cells. Most importantly, we found that the appropriate concentration of naringin inhibited the transcriptional activity of HIF1Α, which in turn decreased aerobic glycolysis in colon cancer cells. Generally, naringin reduces glycolysis in colon cancer cells by reducing the transcriptional activity of HIF1Α and the proliferation and invasion of colon cancer cells. This study helps to elucidate the relationship between colon cancer progression and glucose metabolism, and demonstrates the efficacy of naringin in the treatment of colon cancer.
Glycolysis
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Colonic Neoplasms/metabolism*
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Humans
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Hypoxia-Inducible Factor 1, alpha Subunit/metabolism*
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Phosphopyruvate Hydratase/metabolism*
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Flavanones/pharmacology*
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Cell Line, Tumor
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Databases, Genetic
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Cell Proliferation/drug effects*
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Transfection
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Warburg Effect, Oncologic