1.Review on the research progress of Ayurvedic medicine
Yanmin HU ; Meng CUI ; Yingkai ZHAO
International Journal of Traditional Chinese Medicine 2013;35(10):868-874
This paper reviewed the research progress of Ayurvedic medicine in domestic and abroad.The main contents included:the research progress of ayurvedic ancient records and basic theories,morden pharmacological studies,experimental and clinical studies,etc.
2.Discussion on Foreign Traditional Medical Information Monitoring Process and Mode
Yanmin HU ; Meng CUI ; Yingkai ZHAO
International Journal of Traditional Chinese Medicine 2009;31(4):360-361
With the rapid development of internet and computer technology, the interact has become the richest information resource of the world, and there comes a large potential and broad prospect for the development of internet medium information monitoring. In this paper, we discuss the information monitoring mode of foreign traditional medicine which released by the internet medium. We will discuss the monitoring mode in five steps: automatic information collection-information classification and storage-"human-computer cooperated" data processing and information analysis-dynamic output of information- information feedback.
3.Study on mechanisms of gastrointestinal symptoms in renal insufficiency
Yanmin CHEN ; Shi ZHAO ; Hong FAN
Chinese Journal of Digestion 2001;0(09):-
Objective To investigate the gastric empty and electrogastrogram(EGG) in patients with renal insufficiency before and after hemodialysis, and to study the enteric nervous system (ENS) in experimental acute renal failure rats.Methods The comparisons of gastric emptying and EGG before and after hemodialysis were carried out in 15 patients with uremia who have gastrointerstinal symptoms. Acute renal failure models were also established. The neuroplexus of ENS and levels of some gut hormones were investigated. Results The EGG and gastric emptying were abnormal in patients with uremia before hemodialysis, but improved after dialysis. The neuroplexus of ENS with positive nitric oxide synthase(NOS) staining in rats with acute renal failure was significantly decreased. The levels of gastrin, vasoactive intestinal peptide and motilin in rats with acute renal failure were (159.1?55.6)?g/L, (121.6?48.9)pg/L, and (6.32?3.55)pmol/L, respectively, which were significantly different from those of the control group(P
4.Research progress on surface modification of titanium and titanium alloys by ion implantation
Jiao FANG ; Yanmin ZHOU ; Jinghui ZHAO
Journal of Practical Stomatology 2014;(4):560-563
Ionimplantationtechniqueisamethodthatprocessingthematerialsurfacesinordertochangetheirsurfacechemical,physical and mechanical properties in vacuum environment.Titanium and titanium alloys modified by different types of ions can change their surface properties and characteristics,thereby improving the osseointegration and antibacterial properties of titanium implant.This review summarizes the researches of titanium implant surface modified by different ions implanting.
5.Curative effects observatin of Edaravone on the patients with acute massive cerebral infarction
Yanmin ZHAO ; Zhongpeng FAN ; Pin CHEN
Journal of Clinical Neurology 2001;0(05):-
Objective To observe the curative effects of treatment with Edaravone for acute massive cerebral infarction.Methods 48 patients with acute massive cerebral infarction were randomized into the treatment with Edaravone group(Edaravone group,24 patients) and the conventional treatment control group(control group,24 patients).Two groups patients were admitted conventional treatment for cerebral infarction.Edaravone group patients were admitted with Edaravone 30 mg into 100 ml saline infusion introvenously,twice a day,linked 20 ~ 25 d.Respectively before and after the treatment,neurologic function dificit score(NDS),plasma fibrinogen(Fib) content,coagulation blood function,activity of superoxide dismutase(SOD) were examined.The clinical efficacy was compared between the two groups.Results NDS of tow groups after treatment were significantly lower than those of before treatment,activity of SOD were significantly increased than those before treatment(all P0.05).Significant efficiency ratio of the Edaravone group(87.5%) was significantly higher than that of the control group(45.8%)(P
6.Finite element analysis of three kinds of implants with different pitches under concentrated load
Jinghui ZHAO ; Yanmin ZHOU ; Yunliang ZHAO ; Chunyan LI
Journal of Practical Stomatology 2009;25(6):820-823
Objective; To investigate the stress distribution in implant-bone interface with different pitches by three-dimension finite element analysis method in order to decide the best design of thread parameters for stress distribution. Methods: Built three-dimension finite element models of partial mandible and dental implant with superstructure. The stress distributions in bone and three kinds of implants whose pitches were 0.6, 0.8 and 1.0 mm respectively, under axial and oblique 45 degree to axle concentrated load. Data were analyzed by Cosmos/works software. Results;The maximal Von-Mises stress, tensile stress and compressive stress of implant with 0.8 mm pitch were lower than others, the stress distribution was even. The stresses in the same model under oblique load were much higher than those under axial load. The stress concentrated more on implant neck, upper part of cortical bone and the lowest thread on implant. Conclusion; The pitch of implant has effect on stress distribution in implant-bone interface and the transmission of occlusal force. The lower threads on implant should be cut to avoid the concentration of stress, and the non-axial force should be reduced as possible as we can or avoided when we design and make implant denture.
7.Current situation analysis on resource and service of traditional medicine of China and India
Yanmin HU ; Meng CUI ; Yingkai ZHAO ; Xiaoling WU ; Ming XUE
International Journal of Traditional Chinese Medicine 2014;36(3):197-200
Objective To Analyze the development tendency and major influential factors of the resource and service of traditional medicine (TM) by contrasting the statistical data between China and India.Methods The research data came from the governmental statistical date of traditional medicine.The main statistical indicators included:number of TM hospitals,number of beds in TM institutions,number of health personnel of TM,number of visits and inpatients of TM institutions.A contrastive analysis was given based on these data over the period of 2008-2012.Results In 2012,the number of traditional Chinese medicine (TCM) hospital per ten million populations was 25.1,the number of Traditional Indian Medicine (TIM) hospital per ten million populations was 25.9; the number of beds in TCM institutions per ten thousand populations was 4.5,the number of beds in TIM institutions per ten thousand populations was 0.5; the number of TCM physicians and physician assistants per ten thousand populations was 2.6,the number of TIM physicians and physician assistants per ten thousand populations was 5.9.In 2012,the numbers of visits and inpatients of governmental public TCM hospitals were 426.671 million and 16.882 million; the numbers of visits and inpatients of governmental public TIM hospitals were 73.445 million and 0.947 million.Conclusion There was no significant difference in the number of TM hospitals per ten million populations between China and India.China had obviously advantages in the number of beds in TM institutions,number of visits and inpatients of TM institution.India had obviously advantages in the number of TM health personnel.
8.Clinical features of bacterial liver abscess in diabetic patients
Xiaoqin ZHAO ; Yanmin JIANG ; Xiaowei ZHU ; Xiang XU ; Lan XU
Chinese Journal of Endocrinology and Metabolism 2012;28(1):48-50
This retrospective analysis showed that the most frequent pathogen causing bacterial liver abscess was Klebsiella pneumoniae in 138 patients.Compared with the patients without diabetes mellitus,it was found that:( 1 ) the percentage of diabetic patients having typical abdominal pain was lower ( P < 0.05 ) ; ( 2 ) neutrophilic granulocytosis was more marked,but albumin and hemoglobin levels were lower in diabetic patients( P<0.05 ) ; ( 3 )more diabetic patients were complicated with urinary tract infection and suffered from septicemia( P<0.05 ) ; (4) the clinical course of treatment in diabetic patients was much more prolonged( P<0.05 ).
9.The observation of the expression changes of protein gene product9.5 in neurons from the gastric walls of rats with gastritis
Beibei LI ; Yanmin ZHAO ; Hui XU ; Zongxiao SHANGGUAN
Journal of Chinese Physician 2011;13(7):926-929
Objective To discuss the possible enteric nervous pathogenesis in gastritis related GI motor disorders on the expression changes of protein gene product9. 5 in neurons from the gastric walls of gastritis rat model. Methods 35 clean grade Wister rats were randomly divided into 3 groups, which included gastritis group A (n =10), gastritis group B(n =15) and control group(n =10). Rats in gastritis group A and B received gastric perfusion of HP and the mixture of 2% aspirin and 0. 6N hydrochloric acid respectively. The control group only received gastric perfusion of saline. All of the rats were killed and the gastric mucosal tissues were obtained for the pathological and HP examination. After immunohistochemical pretreatment, the tissues were stained with PGP9. 5 and at the same time the maximum diameter (Dmax, μm), mean area(μm2) and mean optical density (nm) of the neurons from the gastric walls were compared among the groups with Image-Pro Plus professional image analysis system. Results In gastric group A, HP could be found sparsely in the mucous layer or gastric pits, and all of the rapid urease tests were positive. In the other two groups, HP could not be found, and all of the rapid urease tests were negarive. In both gastric group A and B, different grades of inflammatory cell infiltration with active inflammation signs could be found in the deep layers of mucosa, while the control group was normal. The expression mean area, mean optical density of neurons from the gastric wall of rat in group A[(77. 10 ±48. 46) μm2, (53. 25 ±41.40) nm] or B [(73. 92 ± 39. 60) μm2, (45.33 ± 33.20) nm] was obvious lower than control group [(143.51 ± 29. 84) μm2, (85. 00 ± 14. 32) nm], while there was no significant difference between gastric group A and B (P >0. 05) (table 1). Conclusions Hp and NSAIDs might cause gastritis and decrease the PGP9. 5 expression of Neurous from gastric walls. The decrease of PGP9. 5 expression of neurons from the gastric wall might contribute to the pathogenesis of GI motor disorders or symptoms of functional dyspepsia.
10.Polysorbate-80 modified neurotoxin nanoparticle with its transport and cytotoxicity against blood-brain barrier.
Yanmin ZHAO ; Aixiao XIA ; Yinghui WEI ; Yeping RUAN ; Fanzhu LI
Acta Pharmaceutica Sinica 2010;45(10):1312-6
This study was aimed at the transport across blood-brain barrier (BBB) of polysorbate-80 modified neurotoxin loaded polybutylcyanoacrylate nanoparticle (P-80-NT-NP) and its cytotoxicity. An in vitro model of BBB using rat brain microvascular endothelial cells (rBMECs) was established. The cytotoxicity of P-80-NT-NP was measured by the MTT assays, where neurotoxin (NT), nanoparticle (NP), neurotoxin nanoparticle (NT-NP) as control, and the permeability of P-80-NT-NP was determined by using of Millicell insert coculture with rBMECs and fluorescence spectrophotometry. MTT results showed that NT, NP, NT-NP and P-80-NT-NP were avirulent to rBMECs when the concentration of NT was lower than 200 ng x mL(-1). But the cytotoxicity of NP, NT-NP and P-80-NT-NP would be augmented accordingly as concentration increased (P < 0.01), causing obvious reductions of cell survival rate, with no significant difference between them (P > 0.05). When the concentration of NT was 150 ng x mL(-1), the permeability on rBMECs of P-80-NT-NP and NT-NP were both significantly higher than that of NT (P < 0.01), and the permeability of P-80-NT-NP was greater than that of NT-NP (P < 0.05). In conclusion, polysorbate-80 modified neurotoxin nanoparticles can transport across the BBB, while concentration of NT is greater than 200 ng x mL(-1), P-80-NT-NP has a little cytotoxicity against rBMECs.