In recent years,nuclear medical imaging has become a routine examining technology.In general,angiographic medicine has to be injected into human body.Considering the short-coming of the manual injection,it seriously needs a injecting pump with the functions such as auto-control,push-pull injecting,synchronous injection of two injectors.

Objective To analyze the genetic polymorphism of GSTM1 to lung cancer patients in north Sichuan of China and compare with race from other district.Methods PCR-based technique was used to detect the genotypes of GSTM1 in lung cancer patients.Results In local lung cancer patients,the frequency of homozygous deletions(null genotype) for GSTM1 was 58.4 % (73/125).Among the patients,the frequencys of null genotype for GSTM1 were 62.5 % (20/32) in female,56.9 % (53/93) in male,56.1% (32/57)in patients with squamous cell carcinoma and 54.8 % (17/31) in patients with adenocarcinoma,respectively.The frequency of deletions of GSTM1 in lung cancer patients from north Sichuan of China is slightly exceeding those of Europe and Americas (P ＜0.05) and similar to the domestic result (P ＞0.05).Conclusion The genetic polymorphism of GSTM1 to lung cancer patients in north Sichuan of China dosen' t show distinguished feature for this district and race.

Objective: To explore the clinical efficacy and prognostic factors of first-generation and second-generation tyrosine kinase inhibitors (TKI) based regimen in the treatment of patients with BCR-ABL positive acute lymphoblastic leukemia (ALL) . Methods: Retrospectively analyze the clinical characteristics and prognostic factors of 89 patients with BCR-ABL positive ALL from April 2012 to June 2018 in our hospital, the clinical efficacy of first-generation and second-generation TKI was compared. Results: 60 patients were classified into the first-generation TKI (imatinib) group, and 29 patients were in the second-generation TKI (dasatinib) group. There were no significant differences in gender, age, WBC, hemoglobin concentration, PLT, chromosomal karyotype, the types of fusion genes, allogeneic hematopoietic stem cell transplantation (allo-HSCT) and TKI initiation time between the two groups. The first-generation and second-generation TKI groups, for which the complete remission (CR) rate at the fourth week of induction therapy was 83.3% and 89.7% (P=0.637) , respectively, and the complete molecular remission (CMR) was 48.3%and 58.6% (P=0.363) , respectively, the difference was not statistically significant. The 2-year overall survival (OS) rate of first-generation and second-generation TKI group was 34.9% and 64.0% (χ²=4.743, P=0.029) , the 2-year relapse free survival (RFS) rate was 17.2% and 55.0% (χ²=8.801, P=0.003) , respectively. Multivariate analysis showed that complete molecular remission (HR=0.281, 95%CI 0.151-0.523, P<0.001) was independent favorable prognostic factor for overall survival (OS) , complete molecular remission (HR=0.209, 95%CI 0.112-0.390, P<0.001) and second-generation TKI (HR=0.318, 95%CI 0.158-0.641, P=0.001) were independent favorable prognostic factors for RFS. Conclusion For TKI-based regimen of BCR-ABL positive ALL, second-generation TKI is superior to first-generation TKI in OS and RFS time.

Objective:To explore the effects of professional perception based empathy training on clinical communication competency, perceived professional benefits and self-efficacy of junior nurses.Methods:The study was designed with the quasi-experimental study. From March to September 2018, a total of 67 junior nurses with low levels of self-efficacy at Henan Cancer Hospital were recruited as subjects with the way of voluntary registration. All of nurses were divided into 5 groups, 12 to 15 nurses in each group. This study carried out the face-to face empathy training taking professional perception as the main content5 times for 5 weeks. The effects were evaluated with the Nurses' Clinic Communication Competency Scale, Nurses' Perceived Profession Benefits Questionnaire and the General Self-efficacy Scale (GSES) before and after training. SPSS 22.0 statistical software was used in statistical analysis.Results:There were three nurses quitting the training and 64 nurses completed the training. Among 64 nurses, the total average scores of clinic communication competency, perceived professional benefits and general self-efficacy after training were (3.75±0.66) , (4.65±0.40) and (2.53±0.20) respectively higher than those before training with statistical differences ( t=5.058, 7.911, 25.979; P<0.01) . Conclusions:Professional perception based empathy training can improve clinical communication competency, perceived professional benefits and self-efficacy of junior nurses which could be further expanded and applied in nurses.

Objective To explore the influence of spiritual care training program on nurses' spiritual well-being and spiritual care competency. Methods From March to September 2018,a total of 80 nurses working in a provincial cancer hospital were recruited by voluntary registration to participate in this study. They were randomly divided into experimental group(n=40)and control group(n=40)by random number table. The experimental group received the specially designed spiritual care training twice a month for 6 consecutive months on the basis of regular vocational studies. The main forms included expert lectures,group interventions, providing spiritual care for cancer patients,and clinical case reporting. The control group participated in the vocational study organized by the hospital for 6 consecutive months. Before and after the training,the Nurses' Spiritual Health Scale and the Spiritual Care Cognitive Scale were used to investigate and test the nurses in two groups,and the implementation effect was compared. Results After 6 months of training, the total scores of Nurses' Spiritual Health Scale and the Spiritual Care Cognitive Scale in the experimental group were (106.30±8.72)and(185.75±16.53), which were higher than those in the control group, and the differences were statistically significant(t=5.38,4.52;P< 0.01);the scores in each dimension were also higher than those in the control group, and the differences were statistically significant(t=2.22-5.22,P< 0.05). And in the experimental group the total scores and scores in each dimension of Nurses' Spiritual Health Scale and the Spiritual Care Cognitive Scale after the intervention were higher than before the intervention, and the differences were statistically significant(t=3.18-8.99,P<0.01). Conclusions The spiritual care training program based on the concept of self-growth with patients can improve nurses' spiritual well-being and nurses' perceptions of spiritual care.

Objective:To explore the effects of career cognition evaluation-based empathy ability training in nurses with moderate and severe level of job burnout.Methods:This study belonged to quasi-experimental study with comparison before and after intervention. From August 2018 to January 2019, a total of 58 nurses with moderate and severe level of job burnout volunteered as subjects in Henan Cancer Hospital.All of the 58 nurses were divided into four groups, 12 to 15 cases in each group. The face to face career cognition-based empathy ability training was carried out for 6 times within 6 weeks. The training effects were compared with the Maslach Burnout Inventory-general Survey (MBI-GS) , General Well-being Schedule (GWB) and Professional Identity Scale before and after training.Results:The score of job burnout of nurses decreased from (11.50±1.13) before training to (7.87±1.87) after training; the total score of general well-being increased from (65.52±10.84) to (77.00±9.49) ; the score of professional identity raised from (30.22±7.90) to (38.03±8.59) with statistical differences ( t=12.864, -6.351, 7.972; P<0.01) . Conclusions:Careercognition-based empathy ability training can alleviate the burnout of nurses with moderate and severe level of job burnout, improve nurses' professional identity and happiness index.

Objectives: . The mitochondrial ribosomal protein L14 (MRPL14) is encoded by a nuclear gene and participates in mitochondrial protein translation. In this study, we aimed to investigate the role of MRPL14 in thyroid cancer. Methods: . We investigated the association between MRPL14 expression and clinicopathological features using The Cancer Genome Atlas (TCGA) and Chungnam National University Hospital (CNUH) databases. Functional studies of MRPL14, including proliferation, migration, invasion, mitochondrial oxidative phosphorylation and reactive oxygen species (ROS) production, were performed in papillary thyroid cancer (PTC) cell lines (B-CPAP and KTC-1). Results: . Based on the TCGA dataset, PTC tissues lost mitochondrial integrity and showed dysregulated expression of overall mitoribosomal proteins (MRPs) compared with normal thyroid tissues. Of 78 MRPs, MRPL14 was highly expressed in thyroid cancer tissues. MRPL14 overexpression was significantly associated with advanced tumor stage, extrathyroidal extension, and lymph node metastasis. MRPL14 increased cell proliferation of thyroid cancer and promoted cell migration via epithelial-mesenchymal transition-related proteins. Moreover, MRPL14 knockdown reduced the expression of oxidative phosphorylation complex IV (MTCO1) and increased the accumulation of ROS. Cotreatment with a ROS scavenger restored cell proliferation and migration, which had been reduced by MRPL14 knockdown, implying that ROS functions as a key regulator of the oncogenic effects of MRPL14 in thyroid cancer cells. Conclusion . Our findings indicate that MRPL14 may promote cell growth, migration, and invasion by modulating ROS in thyroid cancer cells.

OBJECTIVETo explore the clinical and survival significance of CD20 positive adult patients with B-lineage acute lymphoblastic leukemia (B-ALL).

METHODSThe clinical features and survival of 168 adult patients with B-ALL diagnosed and treated in our department from May 2007 to July 2011 were analyzed retrospectively, 58 expressed CD20 and 110 not.

RESULTSThe sex, distribution of age, anemia, thrombocytopenia, infiltration of liver, spleen and lymph nodes, the expression of myeloid lineage marker, incidence of Ph chromosome, complete remission within 4 weeks showed no significant differences in CD20 positive and negative groups (P>0.05); median white blood cell count at diagnosis and the rate of patients with high white blood cell count in CD20 positive group were 19.2×10⁹/L and 37.9% respectively, which were significantly higher than those of 6.93 × 10⁹/L and 20.9% in CD20 negative group (P<0.05); cumulative incidence of relapse between two groups showed significant difference (P<0.05); multivariable analysis for overall survival and progress-free survival identified CD20 positivity as independent predictor.

CONCLUSIONThe expression of CD20 in adult patients with B-ALL appeared to be associated with high white blood cell count and poor prognosis.

Adult ; Antigens, CD20 ; Cell Lineage ; Disease-Free Survival ; Humans ; Leukocyte Count ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma ; Recurrence ; Remission Induction ; Retrospective Studies ; Survival Analysis

Acute Disease ; Breast Neoplasms ; therapy ; Humans ; Leukemia ; therapy

Antineoplastic Combined Chemotherapy Protocols ; therapeutic use ; Humans ; Interferons ; administration & dosage ; Interleukin-2 ; administration & dosage ; Leukemia, Myeloid, Acute ; drug therapy ; Recurrence ; Thalidomide ; administration & dosage