C.Conclusion: The drug releasing rate of Icariin Ointment made of emulsion ointment base is the fastest.

There exists different view in the goal of investigative study.Based on the self-fulfilling cycles of self-regulated learning,the author of the article puts forward that developing the ability of self-regulated learning by doing investigative study according to each phase characteristic of self-regulated learning is one of the important goals of investigative study.

The increase of blood-brain barrier (BBB) permeability is a key link in causing the pathological changes in vasogenic brain edema and inflammatory reaction. In recent years, a number of studies have indicaded that a lot of mediators participated in the structural and functional changes and damage of BBB during the process of cerebral ischemia-reperfusion.

Objective To observe the correctly positioning rate of left-sided double lumen endobronchial tube by combined adjustment of auscultation,PETCO2 and airway pressure changes.Methods Sixty adult patients undergoing thoracic surgery were intubated with Robertshaw DLTs. DLT position is checked and adjusted by fiberoptic bronchoscope（FOB）. Results In the supine position,successful intubation is 57 cases by three combined methods,one of cases is shallower,two of cases are deeper,satisfactory rate is 95 percents;In the lateral decubitus position,successful intobution is 56 cases by three combined methods,two of cases is shallower,two of cases are deeper,satisfactory rate is 93.4 percents.Conclusion Three combined methods that are simple,reliable can be used repeatedly during postural changes without increasing the opportunities for injury,it is clinically a very good approach,but the absolute scope of safety is very small,FOB is necessary for positioning.

Objective To observe the clinical effect of long-term domiciliary oxygen therapy (LTDOT) on chronic obstructive pulmonary disease(COPD).Methods COPD patients were randomly divided into LTDOT group and control group,LTDOT group received LTDOT on basis of conventional therapy,and control group only received conventional thempy.The lung function,blood gas analysis was detectedand quality of life in paracmasis before and after treatment was evaluted.Results After two years, FEV1[(1.42±0.42)L],PaO2[(80.0±2.6)mm Hg,1 mm Hg=0.133 kPa]in LTDOT group were obviously higher than those in control group[(0.72±0.38)L,(55.0±2.2)mm Hg],there were significant differences between two groups(P<0.01).FVC,PaCO2 in two groups were no significant difference(P>0.05).Quality of life in LTDOT group was better than that in control group,average emergency frequency[(2.3±1.2)times] and hospital day[(16.0±2.4)d]in LTDOT group were obviously decwatsed than those in control group [(5.2±1.3)times,(36.0±2.2)d](P<0.01).Conclusion For the patients with COPD paracmasis, LTDOT can increase FEVI,PaO2,elevate quality of life and decrease average emergency frequency and hospital day.

Objective To observe the occurrence of vascular calcification in maintenance hemedialysis (MHD) patients. Method Sixty-nine MHD patients were enrolled in this study. Vascular calcification was evaluated by plain X-my films of chest, upper and lower extremites. Analyzed the relationship of vascular calcification and cardiovascular disease. Results Vascular calcification on X-ray films presented in 38 cases (55%). Of the 23 cases with calcification on arteries of extremites, 14 cases were found to have both intimal calcification and medial calcification. Patients with vascular calcification were older. Ischemic heart disease and cardiac failure appeared more frequently in the patients with vascular calcification. Conclusions Both intimal calcification and medial calcification are frequently found in the MHD patients. Vascular calcification is probablly associated with cardiovascular disease in MHD patients.

Objective To analyze the distribution characteristics and drug resistance change of acinetobacter baumannii in prima‐ry hospital during 2005-2014 to provide reference for clinical rational drug use .Methods The infection characteristics of acineto‐bacter baumannii in primary hospital during 10 years and its resistance to 10 kinds of common antibacterial drugs was analyzed .Re‐sults A total of 576 strains of acinetobacter baumannii were isolated during 2005-2014 ,accounting for 31 .44% of all Gram nega‐tive bacteria ,which was significantly higher than that of Escherichia coli ,pseudomonas aeruginosa and klebsiella pneumonia bacillus (P<0 .05);446 strains were mainly originated from the sputum specimens (77 .43% ) and 290 strains(50 .35% ) from ICU ;the re‐sistant rate was 44 .44% for CSL ,62 .24% for MIN and more than 70 .00% for 8 kinds of antibacterial drugs of IPM ,MEM ,etc .;which to IPM ,CAZ ,SXT showed the declining trend year by year ,while which to MEM ,AMK ,LEV ,MIN showed the rising trend year by year .Conclusion The isolated acinetobacter baumannii strains in primary hospital are rised year by year ,and generally have resistance to commonly used antibacterial drugs ,the clinical doctors should rationally select antibacterial drugs according to the drug susceptibility test results for preventing the occurrence of acinetobacter baumannii infection .

Objective To study the significance of Wnt5a gene expression in gastric carcinoma (GC). Methods The Wnt5a mRNA expressions in SGC7901 cell line and normal gastric mucosa GES-1 cell line were detected by RT-PCR. The Wnt5a protein expressions in 60 GC and 30 matched tumor-adjacent normal tissue samples were examined by immunohistochemistry using the streptavidin-peroxidase method.χ2 test was used to analyze Wnt5a expression on the clinical pathologic features of gastric carcinoma. Results Both Wnt5a mRNA and Wnt5a protein were significantly higher in SGC7901 cells than those in GES-1 cells. The positive rate of Wnt5a protein expression was also significantly higher in GC than that in tumor-adjacent normal tissue (P < 0.05). Positive expression of Wnt5a was associated with higher degree of regional lymph node metastasis and the later TNM stage (P < 0.05). Conclusion Higher expression of Wnt5a seems to promote invasion and metastasis of gastric cancer, and Wnt5a might play an oncogene-like role in the development of gastric carcinoma.

to observe the clinical effects of warm needling on rheumatoid arthritis.Methods:Patients with rheumatoid were treated with warming needling on the major acupoints of Guanyuan(CV 4),Qihai(CV 6),Zusanli(ST 36),Ganshu(BL 18),Shenshu(BL 23) and Pishu(BL 20),in combination with local acupoints and acupoints on the related meridians,meanwhile,other patients were treated with single needling as control. The patients' joint pain,tenderness,swelling,dysfunction index,gripping force,morning stiffness,walking time of 20 meters,rheumatoid factor,erythrocyte sedimentation rate,C response protein,IgG,IgA,and IgM were measured before and after treatments.Results:Warm needling could improve the rheumatoid arthritis patients' symptoms,and had an effective rate of 86.2%,while the single needling had an effective rate of 57.1%(P＜0.01). And the therapeutic effects were related to the disease duration and condition. Conclusion:Warm needling has a better clinical effects on rheumatoid arthritis than the single needling,with obvious functions of anti-inflammation,relieving pain and regulating immunity.

With the deepening of the study on traditional Chinese medicinal quality and the rising requirements of TCM quality control, the demand of setting TCM quality were emphasized,as well as higher education course. Surrounding the purpose of exploring the related issues of the traditional Chinesemedicinal courses setting and promoting the college curriculum innovation capability,the paper mainly discussed the course open orientation, the teaching characteristics, objectives, idea, the core content and the training scheme, as well as the plan of course and teaching material construction depended on these contents.