This paper summarizes the pharmacological action and the application value of Paris Polyphylla, analyzes the current situation of its resource and provides a number of solutions to the resource shortage problem:introduction and domestication;variety development by selection;improvement of cultivation techniques;secondary metabolite with its endophyte;medicinal composition reproduce after fermentation;alternative medicinal composition search and so on.All these solutions above are able to mitigate the problem of Paris Polyphylla′s resource shortage.