Objective To compare the Barcelona clinic liver cancer staging classification (BCLC), the Japan integrated staging score (JIS), the cancer of the liver Italian program score (CLIP) and Chinese staging system in terms of their ability to predict outcomes and to guide option of therapy in patients with hepatocellular carcinoma (HCC) in China.Methods Clinical data of 861 HCC patients from Zhongshan Hospital between 2001 and 2002 were retrospectively analyzed. Patients were classified acccording to different staging systems. Survival for patients in different stages and the effects of therapeutic methods on survival time were compared. Results BCLC, JIS and Chinese staging system showed the ability in predicting survival for patients in different staging. CLIP failed to show significant difference in survival rates for each subgroup. There was no significant difference in survival rate between surgery and transarterial chemoembolization (TACE)/transarterial embolization (TAE) for patients classified as BCLC stage C, CLIP scores more than 3 or Chinese stage Ⅲ a.The survival rate, however, was higher in patients received operation than those received TACE/TAE if they were classified as earlier stages. Conclusions The BCLC, JIS and Chinese staging systems show prospective ability for Chinese HCC patients in prediction outcomes, whereas the BCLC and the Chinese staging systems are better at both predicting outcomes and guiding the option of treatment.

Objective Aimed to develop the evaluation system and weight of hospital orientation training.Methods Literature review,Delphi,questionnaire,AHP to develop the evaluation system and determined the weight with Satty's method.Results The evaluation system includes 3 division's 13 items.Conclusions Course content,teaching method,course difficultness and occupational plan ning play the most important role,and should be paid more attention.

Objective To explore the correlation between breast ultrasound data classification system (BI-RADS) and estrogen receptor (ER),progesterone receptor (PR),proto-oncogene (Cerb-2).Methods The IDC ultrasound imaging of 320 patients diagnosed as breast cancer by surgery and postoperative pathology wasanalyzed,including the size of the lump,edge burr,aspect ratio,the presence of microcalcification,mass internal blood flow of posterior acoustic attenuation,mass,elasticity ratings and mass BI-RADS classification,and the expressions of ER,PR and CerB-2 were detected by immunohistochemical method.Results The positive rates of PR and ER in the mass with burr edge were significantly higher than those in the mass without burr edge,the positive rate of Cerb2 in mass with slight calcifications was significantly higher than that in mass without slight calcifications,and the positive rate of Cerb-2 in mass with flow grade Ⅱ ～Ⅲ was significantly higher than that in mass with flow grade 0 ～ I.The expressions of BI-RADS in mass with positive ER,PR and CerbB2 were significantly higher than those in mass with negative ER,PR and CerbB-2 (P ＜ 0.05).Conclusion There are correlations between molecular biology of breast cancer and edge burr,microcalcification and rich blood flow.

Objective To explore the correlation between breast ultrasound data classification system (BI-RADS) and estrogen receptor (ER),progesterone receptor (PR),proto-oncogene (Cerb-2).Methods The IDC ultrasound imaging of 320 patients diagnosed as breast cancer by surgery and postoperative pathology wasanalyzed,including the size of the lump,edge burr,aspect ratio,the presence of microcalcification,mass internal blood flow of posterior acoustic attenuation,mass,elasticity ratings and mass BI-RADS classification,and the expressions of ER,PR and CerB-2 were detected by immunohistochemical method.Results The positive rates of PR and ER in the mass with burr edge were significantly higher than those in the mass without burr edge,the positive rate of Cerb2 in mass with slight calcifications was significantly higher than that in mass without slight calcifications,and the positive rate of Cerb-2 in mass with flow grade Ⅱ ～Ⅲ was significantly higher than that in mass with flow grade 0 ～ I.The expressions of BI-RADS in mass with positive ER,PR and CerbB2 were significantly higher than those in mass with negative ER,PR and CerbB-2 (P ＜ 0.05).Conclusion There are correlations between molecular biology of breast cancer and edge burr,microcalcification and rich blood flow.

Objective:To evaluate the efficacy and safety of oliceridine for treatment of moderate to severe pain after surgery with general anesthesia in patients.Methods:The patients with moderate to severe pain (numeric pain rating scale ≥4) after abdominal surgery with general anesthesia from 14 hospitals between July 6, 2021 and November 9, 2021 were included in this study. The patients were assigned to either experiment group or control group using a random number table method. Experiment group received oliceridine, while control group received morphine, and both groups were treated with a loading dose plus patient-controlled analgesia and supplemental doses for 24 h. The primary efficacy endpoint was the drug response rate within 24 h after giving the loading dose. Secondary efficacy endpoints included early (within 1 h after giving the loading dose) drug response rates and use of rescue medication. Safety endpoints encompassed the development of respiratory depression and other adverse reactions during treatment.Results:After randomization, both the full analysis set and safety analysis set comprised 180 cases, with 92 in experiment group and 88 in control group. The per-protocol set included 170 cases, with 86 in experiment group and 84 in control group. There were no statistically significant differences between the two groups in 24-h drug response rates, rescue analgesia rates, respiratory depression, and incidence of other adverse reactions ( P>0.05). The analysis of full analysis set showed that the experiment group had a higher drug response rate at 5-30 min after giving the loading dose compared to control group ( P<0.05). The per-protocol set analysis indicated that experiment group had a higher drug response rate at 5-15 min after giving the loading dose than control group ( P<0.05). Conclusions:When used for treatment of moderate to severe pain after surgery with general anesthesia in patients, oliceridine provides comparable analgesic efficacy to morphine, with a faster onset.