0.05).The morbidity of AAD was obviously lower in group B than that in group A(P

OBJECTIVE To investigate the prevention measures of antibiotic-associated diarrhea(AAD) with microecological modulators.METHODS As control group,344 hospitalized adult patients with severe abdomen and/or lung infection but without gastroenteric disease received combined antibiotics treatment for more than five days.other 141 patients with same disease were divided into two test groups randomly.The patients received combined antibiotics treatment plus Bifid Triple Viable capsule(Pei-Fei-Kang)(group A) or Bacillus(licheniformis) capsule(Zheng-Chang-Sheng)(group B).The incidence of AAD in two test groups compared(respectively) to that of(control) group.(RESULTS) In control group,the incidence of AAD for more than 60 years old patients((22.31%)) was(significantly) higher than that of less than 60 years ones(8.88%)(P

Ophthalmic solution of organic-inorganic layered double hydroxides hybrid nanocomposites based on layered double hydroxides(LDH)intercalated with pirenoxine sodium(PRN)and chitosan-glutathione(CG)was prepared, characterized and evaluated using rabbit precorneal retention. Mg-Al-PRN-LDH, Zn-Al-PRN-LDH and CG-PRN-LDH were synthesized by co-precipitation. The nanocomposites were characterized by laser particle sizer, powder X-ray diffraction(X-RD), fourier transform infrared spectra(FTIR)and transmission electron micrographs(TEM). The release of PRN from Mg-Al-PRN-LDH, Zn-Al-PRN-LDH, and CG-PRN-LDH nanocomposites and API in artificial tear was compared. Based on in vivo precorneal retention studies, PRN-LDH and CG-PRN-LDH nanocomposite dispersions showed significantly higher AUC(3. 72-, 7. 59-folds)and MRT(2. 18-, 2. 60-folds)than that of the commercial eye drops group. Organic-inorganic layered double hydroxides hybrid nanocomposites CG-PRN-LDH dispersions could remarkably improve precorneal retention of PRN.

OBJECTIVE: To evaluate the validity of 99mTc-N(NOEt)2 imaging in nasopharyngeal carcinoma mice model compared with 99mTc-MIBI imaging. METHOD: Biodistribution of 99mTc-N(NOEt)2 were performed on Kunmin mice. Nasopharyngeal carcinoma BALb/c nude mice models were replicated by subcutaneous injection of CNE cells. After intravenous injection of 99mTc-N(NOEt)2 or 99mTc-MIBI images were acquired with SPECT, regions of interesting (ROI) were drawn to evaluate the uptake of 99mTc-N(NOEt)2 or 99mTc-MIBI in tumor imaging. Tumor to non-tumor ratios (T/N) were used as index of evaluation. RESULT: Biodistribution study indicated most of 99mTc-N(NOEt)2 was accumulated in liver, kidney, lung and heart. The T/N values had no significant difference between 99mTc-N(NOEt)2 and 99mTc-MIBI at 30 min post injection. The peak T/N value of 99mTc-N(NOEt)2 reached at 120 min post injection. The best time for imaging was 120 min post injection. The T/N ratio was significantly higher in the group of 99mTc-N(NOEt)2 than that of 99mTc-MIBI at 120 min. CONCLUSION 99mTc-N(NOEt)2 can be used for nasopharyngeal carcinoma mice model imaging. The best time of imaging is 120 min. 99mTc-N(NOEt)2 is a potential imaging agent for nasopharyngeal carcinoma.
Animals ; Disease Models, Animal ; Female ; Male ; Mice ; Mice, Inbred Strains ; Mice, Nude ; Nasopharyngeal Neoplasms ; diagnostic imaging ; Organotechnetium Compounds ; Radiopharmaceuticals ; Technetium Tc 99m Sestamibi ; Thiocarbamates ; Tomography, Emission-Computed, Single-Photon