There are some risk points in the management process of enterprises-funded research project,such as verification of the qualification of the client,the audit of the contract,the report of the research results,and the protection of intellectual property.This paper puts forward the management mode of the research project,which is based on the contract management,strengthen the management of enterprises-funded research project from every processes the contract develop,sign,fulfill and delivery.

It has proved to be difficult for administrators of scientific research to improve process management,especially to manage cooperative research projects accomplished by various institutions.In this paper,we took the process management of Scientific Research in Public Interest (SRI-PI) based on a Grade 3A hospital and other 19 institutions as an example,to analyze the application of PDCA cycle in projects management.It is concluded that the comprehensive quality management of research projects should follow the scientific procedure of PDCA cycle.

Objective To establish the mathematical model and perform experimental mensuration on effective slice width for 4-slice spiral CT. Methods First, assuming the spiral slice sensitivity profile (SSP) was Gauss distribution, a formula about effective slice width, defined as the full width at half maximum (FWHM) of SSP, was get. Then, using Philips Mx8000 4-slice spiral CT system and the same CT technique as those used for clinical CT, CTP 528 of Phantom Catphan 500 was scanned with parameters as follows: 120 kV, 150 mAs, 180 mm FOV, 512×512 Matrix, 180° linear interpolation, different pitch and 0.5 mm detector width. Finally, FWHM was got from the coronal multiplanar reconstruction image passing by the center of tungsten ball in CTP528 for each sequence. Results With pitch of 0.500, 0.625, 0.875, 1.000, 1.250, 1.500 and 1.750, the measured FWHM was 0.7, 0.7, 0.7, 0.8, 0.7, 0.7 and 0.7 mm, respectively. With detector width of 0.5, 1.0 and 5.0 mm, the measured FWHM was 0.7, 1.2, and 6.7 mm, respectively. All the measured effective slices were higher than those of theoretical values. Conclusion The relativity between effective slice width and detector width is direct proportion, while that between effective slice width and pitch is non-linear.

Based on Career-Life-Cycle theory and practical experiences,this paper analyzed characters and varied requirements in scientific research during doctors' career development,and discussed the way and effects to construct talent cultivation mode of Research-Life-Cycle for doctors in hospitals.

Objective By analyzing academic publications written by young doctors in a University Affiliated Hospital during 2013-2015,todescribe the characteristics and rules,and analyze the influencing factors,and to build a basis for providing better service and making effective incentive policies.Methods Materials were collected from questionnaire survey and administrative departments,SPSS software was used to analyze the relationship between factors and the numbers of academic papers.Results 214 young doctors published 486 papers in 2013-2015.Results show that people with senior titles and supervise the graduate students,as the PIs of research projects,as a research team PI,fixed time for research,belonging to mature science research team,interdisciplinary cooperation,cooperation with other units,would be able to have more publications.Conclusions Management staffs should know that research fund is important to young doctors to start and follow-up their research work;they Should help the research team to develop and mature,should help young doctors to find and integrate into the research team;ensure young doctors have fixed research time by making policy,should help young doctors to form the good habit of research;Strengthen cross disciplinary construction,help young doctors to carry out inter unit and inter professional collaboration.

Peking University Hospital of Stomatology plays an important role in the advancement of oral science and oral health in China.Management for scientific research is an imperative part of hospital management in an effort to maintain and improve hospital's core competence in scientific research.Hence,the management system should be continuously strengthened in a systematic manner to create a people-orientated and positive working environment.

Objective To investigate the prevalence and risk factors of Toxoplasma gondii infection among key populations in Wuxi City,Jiangsu Province,so as to provide evidences for developing preventive and control interventions for T. gondii in-fection. Methods A questionnaire was designed to conduct face-to-face interviews to HIV/AIDS carriers/patients,tumor pa-tients,pregnant women and pet breeders. The blood samples were collected to test anti-Toxoplasma IgM and IgG antibodies by using ELISA method. Results Totally 404 participants were investigated,and 38 were positive in testing T. gondii antibodies (9.4%),and among these,37(97.4%)were IgG positive and 1(2.6%)was IgM positive. The multivariate logistic regression indicated that age,regularly contacting cats/dogs and being HIV positive were associated with the infection of T. gondii(OR=2.1,2.6 and 2.3,all P < 0.05). Breeding pets,being HIV positive and being tumor patients were more likely to infect T. gondii than being pregnant(OR = 1.5,8.1 and 2.8,all P < 0.05). Conclusion The high infection rate of T. gondii is observed among key populations in Wuxi City,so that the effective measurements should be taken to enhance the intervention among key popula-tions including immunocompromised people,pet breeders or people having bad dietary habits of eating raw food.

Based on domestic and international studies on Career-Life-Cycle theories,this paper analyzed the scientific research data of doctors to elucidate characters of varied steps in clinical and research practices,trying to construct Research Life-Cycle theory for doctors and provide theoretical references of talent cultivation in hospitals.

In order to investigate the biological function of transforming growth factor-β1 (TGF-β1) during fibrosis in denervated skeletal muscle, we recruited sciatic nerve injury model of SD rats in which denervated gastrocnemius was isolated for analysis. At different time points after operation, denervated muscle was examined by several methods. Masson trichrome staining showed morphological changes of denervated skeletal muscle. Quantitative RT-PCR detected the rapid increase of TGF-β1 expression at mRNA level after nerve injury. It was found that a peak of TGF-β1 mRNA expression appeared one week post-operation. The expression of collagen I (COL I) mRNA was up-regulated in the nerve injury model as well, and reached highest level two weeks post-injury. Immunoblot revealed similar expression pattern of TGF-β1 and COL I in denervated muscles at protein level. In addition, we found that the area of the gastrocnemius muscle fiber was decreased gradually along with increased interstitital fibrosis. Interestingly, this pathological change could be prevented, at least partly, by local injection of TGF-β1 antibodies, which could be contributed to the reduced production of COL I by inhibiting function of TGF-β1. Taken together, in this study, we demonstrated that the expression of TGF-β1 was increased significantly in denervated skeletal muscle, which might play a crucial role during muscle fibrosis after nerve transection.

ObjectiveTo investigate expression of TGF-β1,CTGF and collagen deposition in skeletal muscle during chronic entrapment of peripheral nerve. MethodsFifty rats were separated into two groups,control group and experimental group. At different time points after operation, the right gastrocnemius of 5rats from each group were collected for further analysis such as HE, Masson stain, immunohistochemical staining,RT-PCR and Western-blot. Results It was observed that axon degeneration occurred during chronic nerve entrapment,and which was in line with reports from other groups.Moreover,it had been demonstrated that after nerve entrapment,skeletal muscles may form fibrosis and degeneration consequently.Within this pathological procedure,expression of TGF-β1. CTGF and deposition of collagenⅠ changed rapidly when compared with control group.ConclusionOverall,these results indicated that these factors may be important during skeletal muscle degeneration after chronic nerve entrapment.