Objective To investigate the association of prehepatic fat thickness with insulin resistance in women with polycystic ovarian syndrome (PCOS).Methods Thirty-five PCOS patients and 39 controls were randomly enrolled in the study.Prehepatic fat thickness was detected by ultrasound,and fasting glucose (FBG),fasting insulin (FINS),and serum lipids were detected.The homeostasis model assessment of insulin resistance (HOMA-IR) was used to calculate insulin resistance.Results Prehepatic fat thickness was significantly higher in PCOS patients than healthy controls,and prehepatic fat thickness were significantly correlated with HOMA-IR (P ＜ 0.05).The receiver operating characteristic (ROC) curve demonstrated that prehepatic fat thickness had higher sensitivity and specificity in diagnosing PCOS with insulin resistance.Conclusions This study demonstrates that prehepatic fat thickness significantly correlates with insulin resistance and can be used as the markers of insulin resistance in PCOS patients.

Objective To investigate the diagnosis and treatment of acute acalculous gangrenous cholecystitis (AAGC). Methods The clinical data of 46 patients with AAGC treated in our hospital from 1990 to 2006 were retrospocfively analyzed. Results All patients with AAGC were surgically treated when the final diagnosis was confirmed. Of the 46 patients, 32 underwent cholecystectomy, 14 partial cholecystectomy and 5 cholecystectomy, exploration of common bile duct and T-tube drainage. Tow patients died after operation due to toxic shock and multiple organ failure. Conclusions B-mode ultrasonography, laboratory examination, symptoms and clinical signs are the main methods for diagnosis of AAGC. Early diagnosis, careful preoperative preparation and surgical therapy are important to raise curative rate of the disease.

Objective To summarize the experience of diagnosis and treatment of gastric non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue.Methods Twenty-seven patients,proved by pathology,were included in the study.Results Among clinical presentations,the upper abdominal pain,intestinal bleeding,and weight loss were common.Only 1 case was diagnosed definitely from 18 cases with the examination of X-ray barium meal,84.6%(24 of 26 cases)were miss-diagnosed under gastroscopy.All cases underwent operation,among them 25 performed a radical operation.Twenty-four patients were followed up.Conclusion The multiple biopsy sampling from submueosal layer via gastroscope may improve diagnostic rate on gastric non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue.Operative removal of the tumor should be the first choice of treatment.Additional chemotherapy after the surgery increases survival rate.

Objective To explore the clinical features and treatment of the cystic change of thyroid canc-er. Methods A retrospective analysis was made based on the clinical data of 25 patients with cystic change of thyroid cancer from 1994 to 2008. Results lacking the specificity in clinical diagnose, the di-agnosis accuracy of the disease before operation was very low and the misdiagnosis rate was very high. A-mong 25 cases, only one was accurately diagnosed before operation, 3 were reoperated after the accurate di-agnosis by using intra-operative frozen section examination. Conclusions Clinical physicians should raise their awareness to such a disease. To improve the accurate diagnosis of the misdiagnosis of the cystic degen-eration of thyroid cancer, clinical physicians should integrate the examinations including B-ultrasound, preop-erative fine-needle aspiration biopsy,and intra-operative frozen pathological section.

Objective To evaluate and compare the efficacy and toxicity of gemcitabin(GEM) plus cisplantin and GEM on the chemotherapy of elderly patients advanced non-small-cell lung cancer (NSCLC).Methods 85 elderly patients with stage 3 to 4 NSCLC were randomized into gemcitabine plus cisplatin (group GP) and GEM (group GEM).In group GP,patients received GEM on day 1 and day 8 at dose 1.0 g/m2,add cisplatin on day 2 to day 4 at dose 75 mg/m2. In group GEM, patients would received single GEM at dose 1.25 g/m2.The the therapy circle was 3 weeks and undertaken least 2 circles before the treatment efficacy and survival would be evaluated according RECIST. Results In GP group the response rate was 48.84 ％(21/43),In GEM group the response rate was 35.71％(15/42),the difference of response rate between two groups was not statistically significant(x2=1.708,P=0.424).The median survival were 11 months to Gp group and 9 months to GEM group. The 1 year survival rates of GP group were 39.53 ％ and of GEM group were 26.19 ％. The survival time between two groups was not statistically significant(t=1.377,P=0.172).The same toxicity in both groups was defected, Nausea and vomiting occurred were more serious in GP group than that in GEM group (x2=9.796, P=0.002). Conclusion GP and GEM are both effective for treatment of elderly advanced NSCLC.There are no significantly differences on efficacy and toxicity in 2 groups. Side effects on alimentary system are obviously less in GEM group than that in GP group.

Objective To observe the clinical effect of Shexiang Baoxin pill,a traditional Chinese medicine,combined with nicorandil on microvascular angina pectoris.Methods Seventy patients with microangiopathic angina diagnosed by coronary angiography admitted to the First Affiliated Hospital of Baotou Medical College from January 2014 to August 2016 were enrolled,and they were divided into a control group and an observation group according to conplete random number table method,35 patients in each group.Both groups were given routine treatment,in the observation group,additionally,nicorandil 5 mg 3 times a day and 2 Shexiang Baoxin pills (22.5 mg per tablet),3 times a day were orally applied,the therapeutic course in both groups being 6 weeks.Before and after treatment,the changes of number of episodes of angina pectoris per week,of the total number of ST-segment depression leads and the minimum voltage amplitude of ST-segment depression in the 12-lead resting electrocardiogram and adverse reaction were observed in the two groups.Results The frequency of angina pectoris after treatment was less than that before treatment,the total number of ST segment depression leads was lower and the minimum voltage amplitude of ST segment depression was decreased compared with those before treatment in the two groups,the degree of change in the observation group being more significant than those in the control goup [angina attack frequency (times):5.2 ± 0.5 vs.9.4 ± 1.6,ST segment depression lead total number:2.3-± 0.2 vs.4.6 ± 2.1,ST segment depression lowest voltage amplitude (my):0.10 ± 0.01 vs.0.31 ± 0.01,all P ＜ 0.05].The adverse effects incidence showed no statistical significant differences between control group and observation group [14.3％ (5/35) vs.22.8％ (8/35),P ＞ 0.05] Conclusions On the basis of conventional medication,Shexiang Baoxin pills combined with nicorandil has obvious therapeutic effect for treatment of microangiopathic angina pectoris.

AIM:To establish the quality standard of the composition of Yuquan Micropill(Radix Rehmanniae,Fructus Schisandrae Chinensis,Radix Puerariae lobatae,etc.). METHODS: The composition of Yuquan Micropill were identified by TLC and the content was determined by HPLC.Puerarin could be separated through Diamonsil~(TM) C_(18) column(5 ?m,250 mm?4.6 mm) with methanol-water(1.2∶3 by volume) as a mobile phase.The flow rate was 1.0 mL/min,the detection wavelength was set at 250 nm and the column temperature was maintained at 40 ℃.?-Schizandrin could be separated through Kromasil KR100-3.5 C_(18) column(100 mm?4.6 mm) with methanol-water(3.5∶1 by volume) as a mobile phase.The flow rate was 0.6 mL/min and the detection wavelength was set at 254 nm. RESULTS: The spots in the TLC were clear and could be well separated,the blank and adjuvant contrast could not be interfered.HPLC showed a good peak form,good resolution and could not be interfered by the foreign matter.The average recovery of puerarin was 99.24%,RSD=0.84%,RSD of precision was 0.95%,RSD of reproducibility was 0.86%,RSD of stability was 0.44%.The average recovery of ?-schizandrin was 99.74%,RSD=0.78%,RSD of precision was 1.89%,RSD of reproducibility was 1.76%,RSD of stability was 1.82%. CONCLUSION: The method is simple and has good resolution,strong specificity and good reproducibility,It can be used for the quality control of the composition of Yuquan Micropill.

OBJECTIVE:To provide reference for curriculum setting for postgraduates majoring in Science of Chinese materia medica. METHODS:The curriculum setting for postgraduates majoring in Science of Chinese materia medica was comprehensively analyzed from the aspects of the regional differences and unique differences of curriculum setting and correlation of curriculum set-ting combined with professional interest of students,actual needs of the professional field and relevant circumstances of industry de-velopment. RESULTS & CONCLUSIONS:The curriculum setting exists regional differences and unique differences. It should show positive correlation with professional interest of students,actual needs of the professional field and relevant circumstances of industry development. It needs further exploration and improvement in the construction of curriculum to make it more scientific and systematic,and the curriculum contents should be able to match the training mechanism and pattern for the cultivation of postgradu-ates .

Objective To observe the dynamic changes in collagen type Ⅰ and collagen type Ⅲ in rabbits with schistosomiasis japonica and the treatment effect of gamma interferon on the degradation of collagens in schistosomal hepatic fibrosis.Methods Each rabbit was infected with 80?1 S japonicum cercariae. Liver operations were done at different time points after infection and the liver specimens were embedded with paraffin and stained with ? SMA, HE and picric acid Sirius red. The stained slides were observed under polarizing microscope and different collagen areas calculated by computer imagine analysis system. At the 16th week after infection, the infected rabbits received a single dose of praziquantel and gamma interferon for 8 weeks.Results The area percent of collagen type Ⅰ at the 28th week after infection (40 14?17 00) increased about seven fold compared with the 8th week group (5 73?3 40). The area percent of collagen type Ⅲ at the 28th week after infection (6 80?5 19) increased about six fold compared with the 8th week group (1 15?1 34). The ? SMA positive cells also increased significantly. After gamma interferon treatment, the area percent of collagen type Ⅰ and type Ⅲ decreased significantly, from 18 51?7 52 and 4 63?3 64 (before treatment) to 3 09?1 54 and 0 40?0 37 (0 and 4 weeks after treatment) ( P