Objective To compare the effects of two different chemotherapies in treatment acute myeloid leukemia(ALM) patients.Methods sVEGF concentration was measured by ELISA in 32 AML patients.Section one,15 patients,combined with Ara-C,daunorubicin,etoposide and intrathecal Ara-C.Section two,17 patients,consisted of a combination of Ara-C,idarubicin,etoposide,mitoxantrone and intrathecal Ara-C.Results sVEGF level was significantly increased in newly diagnosed AML.The level of sVEGF in AML after 2 cycles of standard chemotherapy was significantly lower than newly diagnosed cases,but the effect of section two was much better compared with section one.Compared with the section one,the complete remission rate of section 2 was 82.4％ (P ＜ 0.05 ).Conclusion sVEGF as a proangiogenesis factor was significantly increased in serum with AML.The level of sVEGF in patients with AML obtained thermotherapy was significantly lower than that of pre-treating AML ones.VEGF should play a very important role in the leukemogenic process.The section two therapy should be used clinically.

Objective To investigate the clinical effectiveness of peripherally inserted central catheters(PICC) and peripheral intravenous catheters(PIV) in tumor chemotherapy. Methods A total of 180 patients with intravenous chemotherapy were randomly divided into two groups. 108 patients in the PICC group, 72 patients in the PIV group. The holding time and complications were observed and compared. Results The rate of complication in the PICC group were much lower than the PIV group, however was much longer than the PIV group in holding time. But there was no statistical difference in the positive culture rate of bacteria of two groups. Conclusions It is very safe to use PICC which can reduce the rate of complication of catheters and venipuncture times and is worthy of spreading in practice.

ObjectiveTo establish a method for the determination of Nuezhenide and Apiganin 7-O-neohesperidoside in Shanxiangyuan tablets.Methods The Luna C1s column was used,the mobile phase consisted of HCN-0.5％H3PO4(41 ∶ 59),the flow rate was 1.0 ml/min,the column temperature was 30℃,the UV detector was set at 336nm.Results The linear response range was 0.016～0.32 mg/ml (r=0.9997) and 0.006～0.11 mg/ml respectively.The average recovery rate was 99.0％ and 97.5％ respectively,RSD was 1.83％ and 1.57％ respectively,ConclusionThe method was simple,accurate and repeatable.It can be applied in quantitative determination of Nuezhenide and Apigenin 7-O-neohesperidoside in Shanxiangyuan tablets.

Objective:To establish a method for the determination of cinnabar and realgar in Xiao' er Zhibao pills. Methods:Mercury in cinnabar and arsenic in realgar in Xiao'er Zhibao pills were determined respectively by atomic absorption spectrometry (AAS) and inductively coupled plasma atomic emission spectrometry(ICP-AES). Results: A good linear correlation of mercury and arsenic was observed within the range of 5-100 μg·ml-1(r=0. 999 9) and 2-50 μg·ml-1(r=0. 999 2), and the average recovery was 99. 3% with RSD of 3. 0% (n=6) and 104. 5% with RSD of 2. 1% (n=6) by AAS. A good linear correlation of mercury and arsenic was observed within the range of 0.1-20.0 μg·ml-1(r=0.999 97) and 0.1-20.0 μg·ml-1(r=0.999 99),respectively, and the average recovery was 96. 6% with RSD of 1. 4%(n=6) and 104. 1% with RSD of 1. 1% (n=6) by ICP-AES,respectively. Conclusion:The method is accurate and specific, and can be used for the quality control of Xiao'er Zhibao pills.

Neovascular glaucoma (NVG) is a kind of devastating secondary glaucoma characterized by neovascularization in iris and anterior chamber angle,which often results in loss of vision.The current standard of treatment includes retinal ablation and control of enhanced intraocular pressure with drugs and surgical therapy.There are a lot of surgical therapies of NVG,while the prognosis of these therapies are not satisfactory as most of them would be effected by different kinds of complications.Ahmed glaucoma valve implantation (AGVI) is one of the main treatments means being widely used with less postoperative complications,such as shallow anterior chamber,low intraocular pressure.Failure of AGVI mainly caused by fiber hyperplasia and neovascularization.AGVI combined with anti-fibrosis therapy and anti-vascular endothelial growth factor (VEGF) therapy might be a promising method to promote surgical outcomes.It has been shown that AGVI combined with anti-VEGF drugs can improve the success rate of surgery.Besides,some researchers found that AGVI with intraoperative application of anti-fibrosis drugs,such as mitomycin C,sustained-release anti-fibrosis drugs can improve the prognosis of surgery in neovascular glaucoma patients.The progress of research on anti-fibrosis and anti-VEGF treatment combined with Ahmed glaucoma valve implantation was discussed in this review.

Objective To explore the curative effect of budesonide combined with terbutaline via atomiza-tion-inhalation in treatment of the acute episode of infantile asthma and its impaction on pulmonary function. Methods 80 children with acute episode of bronchial asthma were randomly divided into observation group and control group. Both groups received comprehensive therapy, moreover, the observation group was treated with aerosol inhalation of budesonide and terbutaline additionally. Results The excellence rate (65% ) and the total effective rate (98% ) of the observation group was significantly higher than those of control group(30% ,75% ) (P <0.05). In control group, there were no significant differences in FEV, and FEV,% between the pre-treatment and post-treatment (P>0.05). In observation group,FEV1 and FEV1% post-treatment were higher than those in pre-treatment(P<0.05). The improvements of FEV, and FEV, % in observation group were significantly higher than those in control group ( P < 0.05 ). Conclusion The treatment of budesonide combined with terbutaline via atomization-inhalation for the acute episode of infantile asthma could improve the clinical efficacy and pulmonary status, which was a safe, quick and effective method for children' s bronchial asthma.

Objective To explore effect of needle pot ombined with acupiont injection on the treatment of stock flank nervi cutanei inflammation. Methods 104 xases of bright stock flank nervi cutanei inflammation wese di-vided into two groups,the treatment group by the needle pot combined with acupoint injection, The control group used the needle pot treatment only. Results After Ridit analysis, the treatment group obviously surpasses the control group ( P<0.05 ), The treatment group self-conscious symptom and the body drafts vanishes the time obviously surpasses the comparison group(P<0.01 ). Along with ouow-up half ayear, recurrent rate is obviously lower than the control group( P<0.01 ). Conclusion The needle pot unifies the acupuncture point injection treatment stock flank nervi cu-tanei inflammation may clearly enhance the curative effect ,reduces the treatment time and recurrenle.

Objective To observe the effect of pulmonary surfactant-associated proteins ( Kelisu) combined with ambroxol in the treatment of 180 congenital alveolar dysplasia children with neonatal respiratory distress syndrome ( NRDS) .Methods According to random number table ,180 congenital alveolar dysplasia children with NRDS were randomly divided into the observation group and control group , 90 cases in each group .In addition to conventional therapy,the control group was given ambroxol hydrochloride treatment ,the observation group was given Kelisu on thebasis of treatment of the control group.The treatment effect was compared between the two groups .Results Comparedwith the control group,after treatment the values of PaO2 and pH were significantly increased,PaCO2 significantly decreasedin the observation group(t =5.91,13.16,29.89,2.98,5.11,8.13,all P <0.05).The duration of mechanicalventilation,length of hospital stay were (45.30 ±5.35)h,(10.01 ±2.24)d in the observation group,respectively,which were significantly better than[(68.27 ±6.13)h,(17.24 ±2.39)d]in the control group(t =26.78,20.94,all P <0.05).Conclusion Kelisu combined with hydrochloride ambroxol can significantly improve hypoxia symp -toms in NRDS children,reduce the duration of mechanical ventilation and length of hospital stay ,improve the prognosis.

Objective To evaluate the efficacy of Duhuo-Jisheng decoction combined with traditional manipulation for the patients with lumbar intervertebral disc herniation.Methods A total of 126 patients with orthopedic inpatients were enrolled and divided into two group by random number table method: the treatment group (63 patients) and the control group (63 patients).The control group was treated with loxoprofen sodium dispersible tablets, while the treatment group was treated with Duhuo-Jisheng decoction and traditional manipulation. Both groups were treated for 2 courses. After treatment, the patients were evaluated by VAS. The clinical effect was evaluated by Oswestry ODI.Results After treatment, the VAS scores (2.8 ± 0.3 vs. 3.5 ± 0.7, t=7.296) and ODI (10.5% ± 3 .2% vs. 15.5% ± 6.2%,t=5.688) in the treatment group were significantly lower than those in the control group. The time of symptoms relief (2.3 ± 0.5 dvs. 5.3 ± 0.7 d,t=27.681) and the time of symptoms disappearance (28.6 ± 5.7 dvs. 54.4 ± 8.2 d,t=20.506) in the treatment group were significantly less than those in the control group (both Ps<0.01). The total effective rate (95.2% vs. 87.3%) of the treatment group was significantly better than the control group (χ2=3.938,P=0.047). Team of the incidence of adverse reactions (14.2% vs. 41.2%) in the treatment group was significantly lower than that in the control group (χ2=10.128,P=0.002). Conclusions TheDuhuo-Jisheng decoction combined with traditional manipulation can alleviate the symptoms, shorten the treatment time, reduce adverse reactions for the patients with lumbar intervertebral disc herniation.

Objective:To compare therapeutic effect of percutaneous coronary intervention (PCI ) and intravenous administration thrombolysis on aged patients with acute myocardial infarction (AMI) .Methods :A total of 180 aged AMI patients were randomly and equally divided into PCI group and intravenous thrombolysis group (IVT group) . Recanalization rate of infarct‐related artery (IRA) ,left ventricular ejection fraction (LVEF) during hospitalization and follow‐up ,and incidence rate of major adverse cardiovascular events (MACE ) were compared between two groups .Results:Compared with IVT group ,there was significant rise in recanalization rate of IRA (61.1% vs . 92.2% ) ,significant improvement in LVEF at the end of treatment [ (52.26 ± 7.33)% vs . (58.27 ± 7.59)% ,and during follow‐up [on three‐month follow‐up: (53.59 ± 8.04)% vs . (60.44 ± 7.53)% ,on 12‐month follow‐up:(55.16 ± 7.35)% vs .(63.71 ± 7.77)% ] ,and significant reduction in total incidence rate of MACE after 12‐month follow‐up (82.22% vs .24.44% ) in PCI group ,P<0.01 all .Conclusion:Compared with intravenous administration thrombolysis ,the recanalization rate of infarct‐related artery more high ,cardiac function recovers more faster , MACE much less in PCI group ,so PCI can be regarded as a preferred therapeutic plan for aged AMI .