1.Determination of Cinnabar and Realgar in Xiao'er Zhibao Pills
China Pharmacist 2015;18(12):2193-2195
Objective:To establish a method for the determination of cinnabar and realgar in Xiao' er Zhibao pills. Methods:Mercury in cinnabar and arsenic in realgar in Xiao'er Zhibao pills were determined respectively by atomic absorption spectrometry (AAS) and inductively coupled plasma atomic emission spectrometry(ICP-AES). Results: A good linear correlation of mercury and arsenic was observed within the range of 5-100 μg·ml-1(r=0. 999 9) and 2-50 μg·ml-1(r=0. 999 2), and the average recovery was 99. 3% with RSD of 3. 0% (n=6) and 104. 5% with RSD of 2. 1% (n=6) by AAS. A good linear correlation of mercury and arsenic was observed within the range of 0.1-20.0 μg·ml-1(r=0.999 97) and 0.1-20.0 μg·ml-1(r=0.999 99),respectively, and the average recovery was 96. 6% with RSD of 1. 4%(n=6) and 104. 1% with RSD of 1. 1% (n=6) by ICP-AES,respectively. Conclusion:The method is accurate and specific, and can be used for the quality control of Xiao'er Zhibao pills.
2.Comparison of clinical effectiveness of peripherally inserted central catheters and peripheral intravenous catheters in tumour chemotherapy
Chinese Journal of Practical Nursing 2011;27(1):54-55
Objective To investigate the clinical effectiveness of peripherally inserted central catheters(PICC) and peripheral intravenous catheters(PIV) in tumor chemotherapy. Methods A total of 180 patients with intravenous chemotherapy were randomly divided into two groups. 108 patients in the PICC group, 72 patients in the PIV group. The holding time and complications were observed and compared. Results The rate of complication in the PICC group were much lower than the PIV group, however was much longer than the PIV group in holding time. But there was no statistical difference in the positive culture rate of bacteria of two groups. Conclusions It is very safe to use PICC which can reduce the rate of complication of catheters and venipuncture times and is worthy of spreading in practice.
3.Comparison of antihypertensive effects and treatment compliance of extended release nifedipine tablets and nifedipine controlled release tablets
Chinese Journal of Primary Medicine and Pharmacy 2015;(6):865-866,867
Objective To study the antihypertensive effects and treatment compliance of extended release nifedipine tablets and nifedipine controlled release tablets .Methods 120 cases of patients with hypertension from April 2012 to April 2013,with informed consent of patients and in accordance with the medical ethics standard ,were divided into the group I and group II of 60 cases in each group according to the random number table method , the group I was given extended release nifedipine tablets for treatment while the group II was given nifedipine controlled release tablets for therapy ,antihypertensive effect ,treatment compliance and adverse reaction of two groups were com-pared.Results The total efficiency of group II was 93.3%,which was higher than 80.0%of the group I,there was statistically significant differences between the two groups (χ2 =12.019,P=0.019);The adverse reaction rate of group II was 8.3%,which was significantly lower than 18.3%of the group I,there was statistically significant differ-ences between the two groups (χ2 =11.271,P=0.021);The treatment compliance of group II was 96.7%,which of the group I was 95.0%,there was no significant differences between the two groups (χ2 =5.419,P =0.067). Conclusion Nifedipine controlled release tablets has a better antihypertensive effect ,with less adverse reaction when compared with nifedipine controlled release tablets .
4.Comparison of therapeutic effect between PCI and intravenous administration thrombolysis on aged pa-tients with acute myocardial infarction
Chinese Journal of cardiovascular Rehabilitation Medicine 2015;24(6):653-655,656
Objective:To compare therapeutic effect of percutaneous coronary intervention (PCI ) and intravenous administration thrombolysis on aged patients with acute myocardial infarction (AMI) .Methods :A total of 180 aged AMI patients were randomly and equally divided into PCI group and intravenous thrombolysis group (IVT group) . Recanalization rate of infarct‐related artery (IRA) ,left ventricular ejection fraction (LVEF) during hospitalization and follow‐up ,and incidence rate of major adverse cardiovascular events (MACE ) were compared between two groups .Results:Compared with IVT group ,there was significant rise in recanalization rate of IRA (61.1% vs . 92.2% ) ,significant improvement in LVEF at the end of treatment [ (52.26 ± 7.33)% vs . (58.27 ± 7.59)% ,and during follow‐up [on three‐month follow‐up: (53.59 ± 8.04)% vs . (60.44 ± 7.53)% ,on 12‐month follow‐up:(55.16 ± 7.35)% vs .(63.71 ± 7.77)% ] ,and significant reduction in total incidence rate of MACE after 12‐month follow‐up (82.22% vs .24.44% ) in PCI group ,P<0.01 all .Conclusion:Compared with intravenous administration thrombolysis ,the recanalization rate of infarct‐related artery more high ,cardiac function recovers more faster , MACE much less in PCI group ,so PCI can be regarded as a preferred therapeutic plan for aged AMI .
5.Application of Morphology Microscopically Comparison by Using SP-1000i and CellaVision DM96
Journal of Modern Laboratory Medicine 2016;31(3):135-137,142
Objective To improve the objectivity and consistency of microscopically comparison in morphology by using SP-1000i and CellaVision DM96.Methods Ten cases of venous blood samples were collected.The morphological comparison of white blood cells were performed between the traditional method and the new method (by using SP-1000i and CellaVision DM96),at the same time,between 2 veterans and other 10 common operators.According to the same methods,the time was compared.Results By using this new method,the consistency of microscopically comparison was greatly improved (P<0.01),the number of people who need to compare again was decreased obviously(P<0.01),and the time of the procedure was also shortened evidently(P<0.05).Conclusion The quality control of clinic laboratory will must be greatly improved with timesaving and labour-saving when SP-1000i and CellaVision DM96 are applied in microscopically comparison in mor-phology.
6.Determination of Nuezhenide and Apigenin 7-O-neohesperidoside in Shanxiangyuan tablets by HPLC
International Journal of Traditional Chinese Medicine 2012;34(6):519-521
ObjectiveTo establish a method for the determination of Nuezhenide and Apiganin 7-O-neohesperidoside in Shanxiangyuan tablets.Methods The Luna C1s column was used,the mobile phase consisted of HCN-0.5%H3PO4(41 ∶ 59),the flow rate was 1.0 ml/min,the column temperature was 30℃,the UV detector was set at 336nm.Results The linear response range was 0.016~0.32 mg/ml (r=0.9997) and 0.006~0.11 mg/ml respectively.The average recovery rate was 99.0% and 97.5% respectively,RSD was 1.83% and 1.57% respectively,ConclusionThe method was simple,accurate and repeatable.It can be applied in quantitative determination of Nuezhenide and Apigenin 7-O-neohesperidoside in Shanxiangyuan tablets.
7.Clinical observations of acupuncture on treatment of strabismus acquired paralysis
Chinese Journal of Primary Medicine and Pharmacy 2008;15(11):1801-1802
Objective To observe treatment efficacy of acupuncture on the acquired paralysls.Methods Clear diagnosis of acquired paralysis patients 105 cases of sexual walleye were selected.Randomly divided into two groups.Therapy unit gave acupuncture therapy.Results Ridit analysis of the two sets of efficacy(P < 0.05) ,significantly better in the treatment group than the control group treatment time is short group(P <0.01).Follow-up six months.No relapse.Conclusion Acupuncture treatment efficacy exact onset of acquired paralysis.
8.Effect of needle pot combined with acupoint injection on the treatment of stock flank nervi cutanei inflamma-tion
Chinese Journal of Primary Medicine and Pharmacy 2008;15(10):1652-1653
Objective To explore effect of needle pot ombined with acupiont injection on the treatment of stock flank nervi cutanei inflammation. Methods 104 xases of bright stock flank nervi cutanei inflammation wese di-vided into two groups,the treatment group by the needle pot combined with acupoint injection, The control group used the needle pot treatment only. Results After Ridit analysis, the treatment group obviously surpasses the control group ( P<0.05 ), The treatment group self-conscious symptom and the body drafts vanishes the time obviously surpasses the comparison group(P<0.01 ). Along with ouow-up half ayear, recurrent rate is obviously lower than the control group( P<0.01 ). Conclusion The needle pot unifies the acupuncture point injection treatment stock flank nervi cu-tanei inflammation may clearly enhance the curative effect ,reduces the treatment time and recurrenle.
9.Curative effect of budesonide combined with terbutaline via atomization-inhalation in treatment of acute episode of infantile asthma and its impaction on pulmonary function
Chinese Journal of Primary Medicine and Pharmacy 2010;17(15):2030-2031
Objective To explore the curative effect of budesonide combined with terbutaline via atomiza-tion-inhalation in treatment of the acute episode of infantile asthma and its impaction on pulmonary function. Methods 80 children with acute episode of bronchial asthma were randomly divided into observation group and control group. Both groups received comprehensive therapy, moreover, the observation group was treated with aerosol inhalation of budesonide and terbutaline additionally. Results The excellence rate (65% ) and the total effective rate (98% ) of the observation group was significantly higher than those of control group(30% ,75% ) (P <0.05). In control group, there were no significant differences in FEV, and FEV,% between the pre-treatment and post-treatment (P>0.05). In observation group,FEV1 and FEV1% post-treatment were higher than those in pre-treatment(P<0.05). The improvements of FEV, and FEV, % in observation group were significantly higher than those in control group ( P < 0.05 ). Conclusion The treatment of budesonide combined with terbutaline via atomization-inhalation for the acute episode of infantile asthma could improve the clinical efficacy and pulmonary status, which was a safe, quick and effective method for children' s bronchial asthma.
10.Research progress of Ahmed glaucoma valve implantation in the treatment of neovascular glaucoma
Chinese Journal of Experimental Ophthalmology 2017;35(4):368-371
Neovascular glaucoma (NVG) is a kind of devastating secondary glaucoma characterized by neovascularization in iris and anterior chamber angle,which often results in loss of vision.The current standard of treatment includes retinal ablation and control of enhanced intraocular pressure with drugs and surgical therapy.There are a lot of surgical therapies of NVG,while the prognosis of these therapies are not satisfactory as most of them would be effected by different kinds of complications.Ahmed glaucoma valve implantation (AGVI) is one of the main treatments means being widely used with less postoperative complications,such as shallow anterior chamber,low intraocular pressure.Failure of AGVI mainly caused by fiber hyperplasia and neovascularization.AGVI combined with anti-fibrosis therapy and anti-vascular endothelial growth factor (VEGF) therapy might be a promising method to promote surgical outcomes.It has been shown that AGVI combined with anti-VEGF drugs can improve the success rate of surgery.Besides,some researchers found that AGVI with intraoperative application of anti-fibrosis drugs,such as mitomycin C,sustained-release anti-fibrosis drugs can improve the prognosis of surgery in neovascular glaucoma patients.The progress of research on anti-fibrosis and anti-VEGF treatment combined with Ahmed glaucoma valve implantation was discussed in this review.