Objective To study the effect of MRI on the enhancement of normal prostate, benign prostatic hyperplasia and prostate cancer by pharmacokinetic model. Methods A total of 80 patients with prostate cancer diagnosed by pathological examination in Lishui Central Hospital from February 2015 to August 2016 were selected as the subjects in this study. 1.5T superconducting magnetic resonance imaging was used, the serial needle was FMPSPGR for enhanced scan of the prostate of the patient, interlayer was 2 mm and the thickness was 7 mm, continuous scanning was performed 35 times, after the elbow vein indwelling catheter, the Gd-DTPA was injected rapidly at the beginning of the scan according to the 0.1 mmol/kg dose. By scanning data, inspection data transfer and workstation for patients with scanning results were analyzed using two room pharmacokinetic model calculation of ROI, the patients of normal prostate peripheral zone, benign prostatic hyperplasia and prostate cancer index, maximum enhancement of contrast agent distribution index, exchange rate, contrast absorption amplitude. Results After a series of calculation and analysis, the maximum enhancement index of prostate cancer, the distribution index of contrast agent, the contrast agent exchange rate and the contrast agent absorption index of prostate cancer were the highest. The maximum enhancement index, contrast agent distribution index, contrast agent exchange rate and contrast agent absorption index were significantly lower than those of prostate cancer, The difference was statistically significant (P<0.05). The indexes of normal prostate were significantly lower than those of benign prostatic hyperplasia (BPH) and prostate cancer (P<0.05). Conclusion The application of drug evaluation pharmacokinetic model of prostate MRI in different tissues to enhancing effect on patients with prostate tumor and non tumor tissue blood supply characteristics more accurately describe and differentiate, to improve the accuracy of identification and diagnosis of prostate in clinical treatment in a certain extent, with further clinical promotion and application significance.

With the aggravation of aging and the increasing demand of the elderly for pension and medical services,the old-age model of medical care combined with nursing emerges as the times required.Traditional Chinese medicine medical institutions have the advantages and opportunities in the process of developing integrated medical and nursing services,such as the treatment and prevention of chronic diseases,the increasing demand of the elderly for integrated medical and nursing institutions,and the strong support of the state for integrated medical and nursing institutions.However,they are also facing challenges and difficulties such as imperfect team,weak market competition and low payment ability.Through the analysis of opportunities and challenges for TCM medical institutions,this paper provides corresponding counter measures and suggestions for their development.

Objective To investigate the intervention of family doctor management system on the loneliness in people who lost their only child.Methods Sixty two residents who lost their only child in Shanghai Xujiahui district were enrolled in the study from December 2015 to June 2016.The participants were randomly divided into study group and control group with 31 cases in each group;the participants in study group were signed by family doctors and the psychological intervention was provided,those in control group had no intervention,the participants were followed up for 6 months,the psychological status was evaluated with UCLA loneliness scale in two groups.Results There were no significant differences in UCLA scores (63.26 ±7.17 vs.60.03 ±7.59,t =1.709,P ＞0.05) and in the severity of loneliness (mild 0/30 vs.1/31,moderate 9/30 vs.11/31,severe 21/30 vs.19/31,x2 =1.284,P ＞ 0.05) between study and control groups before the intervention.There were significant differences in UCLA scores (63.26 ±7.17 vs.40.13 ± 5.61,t =15.631,P ＜ 0.05) and in the severity of loneliness (mild 0/30 vs.17/30,moderate 9/30 vs.13/30,severe 21/30 vs.0/30,x2 =38.727,P ＜ 0.05) before and after 6 months of intervention in study group;while there were no significant changes in UCLA score (60.03 ± 7.59 vs.59.64 ± 6.90,t =0.650,P ＞ 0.05) and in the severity of loneliness (mild 1/31 vs.0/31,moderate 11/31 vs.14/31,severe 19/31 vs.17/30,x2 =1.471,P ＞ 0.05) in control group after 6-month follow-up.The UCLA scores (40.13 ±5.61 vs.59.64 ±6.90,t =12.086,P＜0.05) and the severity of loneliness (mild 17/30 vs.0/31,moderate 13/30 vs.14/31,severe 0/30 vs.17/31,x2 =34.030,P ＜ 0.05) in study group were significantly lower than those in control group after intervention.Conclusion The family doctor management system can improve the loneliness and mental health status of people who lost the only child,to reduce the risk of mental illness and the family and social burden.