Objective To compare the efficacy and safety of ivermectin with metronidazole in patients with intestinal acariasis.Methods 24 patients with typical intestinal acariasis were selected and divided into two groups,each group had 12 members.Double-blind,randomized clinical trial of ivermectin versus metronidazole was assigned.Results 24 patients completed 3 courses.The total cure rate of ivermectin and metronidazole were 100%(12/12) and 25%(3/12),respectively.There was statistical difference between the two groups(P

Collagen hydrogel is a new type of wound dressing. The combination of the advantages of collagen and hydrogel can effectively exert their respective advantages in wound repair and regeneration. In recent years, the use of physical and chemical method to improve the mechanical properties and biological functions of collagen hydrogels to make them more suitable for wound environment has become a hotspot in scientific research and clinical trials. This review systematically summarized the theoretical basis, application status and research progress of collagen hydrogel in wound repair, and analyzed the current advantages, limitations, and future research directions, to provide reference and directions for the development of collagen hydrogel and its clinical application in the field of wound repair.

Collagen hydrogel is a new type of wound dressing. The combination of the advantages of collagen and hydrogel can effectively exert their respective advantages in wound repair and regeneration. In recent years, the use of physical and chemical method to improve the mechanical properties and biological functions of collagen hydrogels to make them more suitable for wound environment has become a hotspot in scientific research and clinical trials. This review systematically summarized the theoretical basis, application status and research progress of collagen hydrogel in wound repair, and analyzed the current advantages, limitations, and future research directions, to provide reference and directions for the development of collagen hydrogel and its clinical application in the field of wound repair.

Objective: To analyze the association of cytogenetic abnormalities with the prognosis of chronic myeloid leukemia (CML) patients in tyrosine kinase inhibitors (TKI) era. Methods: Karyotype analysis of chromosome G-banding was carried out in 387 newly diagnosed CML patients by short-term culture of bone marrow cells. The correlation of cytogenetic abnormalities and CML progression was explored in combination with ABL tyrosine point mutations. Result: Of 387 patients with positive BCR-ABL fusion gene assayed by fluorescence in situ hybridization (FISH) technique, 94.1% (364/387) patients were Ph positive and 5.9% (23/387) Ph negative; 320 patients (87.9%) had a translocation t (9;22) (q34;q11) and 5 (1.4%) a variant translocation t (v;22) . Additional cytogenetic aberrations (ACA) at diagnosis were found in 10.7% (39/387) Ph⁺ patients, major route ACA in 22 (56.4%) cases and minor route ACA in 15 (38.5%) cases and 2 patients (5.1%) lacked the Y chromosome (−Y) ; 23.4% (71/303) patients occurred ACA during TKI treatment and the most frequent abnormalities were abnormal chromosome numbersd, which were likely associated with high proportion of disease progression (χ²=168.21, P<0.001) and ABL tyrosine point mutations (χ²=29.04, P<0.001) . Newly diagnosed CML-CP patients with t (9;22) (q34;q11) had a longer event-free survival (EFS) and disease-free survival (DFS) rates than that of patients with ACA (P=0.037; P=0.003) , while the overall survival (OS) had no significant differences (P=0.209) . As for CML-CP patients that occurred ACA during TKI therapy would have a marked low OS, EFS and DFS (all P<0.001) compared with no ACA occurred patients. Survival of advanced patients that occurred ACA were dramatically reduced. Conclusion ACA often emerged during the disease progress in CML patients, regular and timely detection of chromosomes karyotype and ABL tyrosine point mutations during TKI treatment was important for therapeutic evaluation, progress and prognosis of CML.

Collagen hydrogel is a new type of wound dressing. The combination of the advantages of collagen and hydrogel can effectively exert their respective advantages in wound repair and regeneration. In recent years, the use of physical and chemical method to improve the mechanical properties and biological functions of collagen hydrogels to make them more suitable for wound environment has become a hotspot in scientific research and clinical trials. This review systematically summarized the theoretical basis, application status and research progress of collagen hydrogel in wound repair, and analyzed the current advantages, limitations, and future research directions, to provide reference and directions for the development of collagen hydrogel and its clinical application in wound repair field.

Collagen hydrogel is a new type of wound dressing. The combination of the advantages of collagen and hydrogel can effectively exert their respective advantages in wound repair and regeneration. In recent years, the use of physical and chemical method to improve the mechanical properties and biological functions of collagen hydrogels to make them more suitable for wound environment has become a hotspot in scientific research and clinical trials. This review systematically summarized the theoretical basis, application status and research progress of collagen hydrogel in wound repair, and analyzed the current advantages, limitations, and future research directions, to provide reference and directions for the development of collagen hydrogel and its clinical application in wound repair field.