Objective To explore the expression of SP-A in surface active substance of sputum pulmonary of dysfunctional venti-latory weaning response patients and to study changes of expression of SP-A and oxygenation index ,arterial partial pressure of oxy-gen .Methods The mechanical ventilatory patients were divide into dysfunctional ventilatory weaning response group (group A) and easily weaning group(group B) ,then collected sputum from ventilators at different times :on the first day ,two and seven days after using ventilators .Used ELISA to test level of SP-A and oxygenation index ,arterial partial pressure of oxygen in sputum of group A and group B .Results For group A ,SP-A content oxygenation index and arterial partial pressure of oxygen were significantly less than those for group B(P<0 .05);after two days ,for group A ,SP-A content in sputum was significantly less than that on the first day ,and SP-A content in sputum was significantly less than that on the second day (P<0 .05);two days later ,oxygenation index and arterial partial pressure of oxygen were significantly lmore than those on the first day (P<0 .05) and there was no statistical difference in oxygenation index and arterial partial pressure of oxygen between the seventh day and the second day (P>0 .05) .Con-clusion Dysfunctional ventilatory weaning response and lung injury related to ventilator can be diagnosed early through the test of SP-A content in sputum ,which provides a brand-new way and method of treatment in dysfunctional ventilatory weaning response and lung injury related to ventilator .

Objective To investigate the efficacy and side effects of three recruitment maneuvers (RM) for severe extra-pulmonary acute respiratory distress syndrome ( ARDS). Methods A total of sixty-three extra-pulmonary ARDS patients were enrolled and randomly divided into three groups, which were treated with sustained inflation (SI),increment of positive end-expiratory pressure (IP) and pressure control ventilation (PCV) respectively. The oxygenation index ( PaO2/FiO2) before and after lung recruitment was recorded in patients with complete lung recruitment,and the cause of discontinuation of lung recruitment was recorded in patients with incomplete lung recruitment. Positive end-expiratory pressure (PEEP) was recorded in patients who completed lung recruitment with the latter two methods when they reached the maximum degree of lung recruitment. The mortality rate of 14 d in 3 groups was recorded, and the clinical characteristics and prognosis differences were compared before and after each group. Results With PaO2/FiO2as the standard, all the three methods of pulmonary reexpansion could make the lungs obviously reexpanse. The PaO2/FiO2of each group before, 5 minutes after and 1 hour after reexpansion were respectively as below (SI group: 70. 4±14. 8 mmHg,306. 8±97. 5 mmHg,229. 6±116. 2 mmHg; IP group:74. 9±13. 6 mmHg,328. 0 ± 95. 5 mmHg,252. 8 ± 111. 0 mmHg; PCV group: 67. 8 ± 14. 9 mmHg, 304. 2 ±82. 2 mmHg,223. 7±83. 6 mmHg. P＜0. 01). There were no significant differences among the three methods in the effect of RM (P＞0. 05). PEEP of IP group is higher than that of PCV group at the time of maximum RM (20. 3±2. 5 cmH2O vs. 18. 5±1. 8 cmH2O,P＜0. 05). There were significant differences in the incidence of adverse reactions caused by the three methods (54. 5%(12/22) in SI group,35. 0%(7/20) in IP group and 9. 6%(2/21) in PCV group. The 14 d mortality of each group was 63. 6%(14/22) in SI group,70. 0%(14/20) in IP group and 61. 9%(13/21) in PCV group,with no significant difference (P＞0. 05) . Conclusion The effects of three methods of lung recruitment on severe pulmonary exogenous ARDS patients were similar, but there was no significant difference in prognosis. Adverse reactions of SI method leads to the greatest probability of discontinuation of lung recruitment,and that of the PCV method is the smallest. Under the same effect of lung recruitment, IP method needs higher PEEP than PCV method. In practice,PCV method should be preferred.