Objective To investigate the value of CEUS in differential diagnosis of benign and malignant renal focal hyperechoic lesions.Methods Data of conventional ultrasound (US) and CEUS of 56 patients with single renal focal hyperechoic lesion were retrospectively analyzed,and differential diagnosis of benign and malignant lesions was performed with US and CEUS,respectively.Taking pathological diagnosis as golden standard,the diagnostic efficacy of US and CEUS were calculated and compared.Results The sensibility,specificity,positive predictive value (PPV),negative predictive value (NPV) and accuracy of US was 70.00％ (14/20),75.00％ (27/36),60.87％ (14/23),81.82％ (27/33) and 73.21％ (41/56),while of CEUS was 80.00％ (16/20),94.44％ (34/36),88.89％ (16/18),89.47％ (34/38) and 89.29 ％ (50/56),respectively.The accuracy,specificity and PPV of CEUS were higher than those of US (all P＜0.05).The consistency of CEUS and pathology was good (Kappa=0.761),while of US and pathology was ordinary (Kappa=0.435).Conclusion CEUS can improve differential diagnostic efficacy of renal focal hyperechoic lesions.

Objective To develop a nomogram for predicting the risks of early anastomotic recurrence(EAR)after primary bowel resection in patients with Crohn's disease(CD).Methods The patients with CD under-going preoperative magnetic resonance enterography(MRE)and primary bowel resection were enrolled in this retrospective study and divided into an EAR group(18 patients)and EAR-free group(12 patients).The EAR group included the patients having an endoscopic Rutgeerts score of≥I2 month or the need for anastomotic resection within 12 months after surgery.All the 38 indexes including preoperative demographic characteristics,laboratory examina-tions,multi-parameter MRE features of the resected intestine and its adjacent mesentery,histological findings,and postoperative pharmacotherapy were analyzed.Least absolute shrinkage and selection operator(LASSO)regression and multivariate binary logistic regression analysis were performed to identify independent risk factors to be incorpo-rated into the nomogram for predicting the risks of early anastomotic recurrence and the prediction performance was evaluated.Results Mesenteric creeping fat index on MRE and comb sign were independent risks of EAR,with a concordance index of 0.882(95%CI:0.764～1).The calibration plot revealed a strong relationship between actual observation and predicted probability of EAR.Conclusions The preoperative MRE-based nomogram may be a potential tool for predicting EAR following surgery in patients with CD,which is beneficial to individual management in those patients.It provides reference for the formulation of early postoperative individualized drug adjuvant therapy in patients at high risk of EAR.