OBJECTIVE: To investigate the association of HLA-DQB1 alleles and artemisia pollen allergic patients of Han and Uygur people in the Xinjiang area. METHOD: PCR-SSP (sequence-specific primer polymerase chain reaction) were used to test fifty Uygur and fifty Han people with allergic rhinitis with hypersensitivity to artemisia pollen in the Xinjiang area. Fifty normal Uygur and fifty normal Han people in the Xinjiang region were enrolled in the control group. RESULT: The frequency of HLA-DQB1 * 05 in the Uygur group with allergic rhinitis was significantly higher (19.4%) than that in the Uygur control group (7%) (P < 0.05). There were no significant difference between in the allergic rhinitis group and in the control group. CONCLUSION HLA-DQB1 * 05 might be the susceptibility genes of the Uygur patients with allergic rhinitis in the Xinjiang area.
Adolescent ; Adult ; Alleles ; Asian Continental Ancestry Group ; genetics ; Case-Control Studies ; Ethnic Groups ; Female ; Gene Frequency ; HLA-DQ beta-Chains ; genetics ; Humans ; Male ; Middle Aged ; Polymorphism, Genetic ; Rhinitis, Allergic, Seasonal ; genetics ; Young Adult

OBJECTIVE: This study aimed to investigate the relationship between CD14 gene rs2569192(C/G), rs3138078 (--1359G/T) and allergic rhinitis (AR) in Xinjiang Uygur and Han populations as well as to determine characteristics of polymorphisms. METHOD: A total of 300 AR and 300 healthy controls subjects were included. The frequencies of genotypes and alleles were detected as well as the levels of tIgE in different genotypes were compared. RESULT: (1) The distribution of genotypes or alleles of CD14 gene rs2569192 (C/G), rs3138078 (--1359G/T) had no differences between the Xinjiang Uygurs and Hans (P > 0.05). The highest frequency of alleles was C, G. (2) The frequencies of genotypes and alleles were not different between the AR and control group in Uygur and Han (P > 0.05). The frequencies of genotypes and alleles of rs2569192 were different between the Uygur AR and Han AR group (P < 0.05). (3) The distribution of genotype frequencies and allele of rs 2569192 in the Xinjiang Uygur and Han population were quite different from Chinese Beijing Han populations, Japanese, European and African (P < 0.05). (4) The serum total IgE level in AR group was higher than that in healthy control group (P < 0.05). CONCLUSION (1) rs2569192 (C/G), rs3138078 (--1359G/T) polymorphisms were not different between the Chinese Xinjiang Uygur and Han population. The major allele were both C and G. rs2569192 of CD14 in Xinjiang populations was different from that in the other populations. (2) No relationship between rs2569192, rs3138078 and AR was found. (3) The serum total IgE level in AR group was higher than that in healthy control group. No relationship between CD14 two SNP and serum total IgE level was found.
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alleles ; Case-Control Studies ; Child ; Child, Preschool ; China ; epidemiology ; Ethnic Groups ; genetics ; Female ; Gene Frequency ; Genotype ; Humans ; Hypersensitivity ; epidemiology ; genetics ; Lipopolysaccharide Receptors ; genetics ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Rhinitis ; epidemiology ; genetics ; Young Adult